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General Considerations in the Diabetic Patient with Peripheral Vascular Disease

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Part of the book series: Contemporary Diabetes ((CDI))

Abstract

The confluence of diabetes and peripheral vascular disease results in a complex relationship in which each contributes to and encourages progression of the other. As the prevalence of each disease increases, the clinician caring for the diabetic patient must be prepared to take several factors into account when assessing and treating vascular disease. The evaluation and diagnosis of peripheral vascular disease is reviewed, as are nonsurgical treatment options. The indications, efficacy, and morbidity of surgical and endovascular revascularization are also discussed, as are the merits of each relative to the other. The benefits of amputation, minor and major, are considered. The frequent phenomenon of the diabetic ulcer with concurrent infection is assessed. Finally, the organization, composition, and benefits of the multidisciplinary care team are considered.

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References

  1. Pande RL, Perlstein TS, Beckman JA, Creager MA. Secondary prevention and mortality in peripheral artery disease: National Health and Nutrition Examination Study, 1999 to 2004. Circulation. 2011;124(1):17–23.

    Article  PubMed  Google Scholar 

  2. McDermott MM. Peripheral arterial disease: epidemiology and drug therapy. Am J Geriatr Cardiol. 2002;11(4):258–66.

    Article  PubMed  Google Scholar 

  3. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241(19):2035–8.

    Article  PubMed  CAS  Google Scholar 

  4. Cooper ME, Bonnet F, Oldfield M, Jandeleit-Dahm K. Mechanisms of diabetic vasculopathy: an overview. Am J Hypertens. 2001;14(5 Pt 1):475–86.

    Article  PubMed  CAS  Google Scholar 

  5. Rahman S, Rahman T, Ismail AA, Rashid AR. Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis. Diabetes Obes Metab. 2007;9(6):767–80.

    Article  PubMed  CAS  Google Scholar 

  6. Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications Trial. Am J Cardiol. 1995;75(14):894–903.

    Google Scholar 

  7. Stokes 3rd J, Kannel WB, Wolf PA, Cupples LA, D’Agostino RB. The relative importance of selected risk factors for various manifestations of cardiovascular disease among men and women from 35 to 64 years old: 30 years of follow-up in the Framingham Study. Circulation. 1987;75(6 Pt 2):V65–73.

    PubMed  Google Scholar 

  8. Margolis DJ, Malay DS, Hoffstad OJ, Leonard CE, MaCurdy T, López de Nava K, et al. Prevalence of diabetes, diabetic foot ulcer, and lower extremity amputation among Medicare beneficiaries, 2006 to 2008: Data Points #1. 17 Feb 2011. Data Points Publication Series [Internet]. Rockville, MD: Agency for Healthcare Research and Quality (US); 2011. Available from http://www.ncbi.nlm.nih.gov/books/NBK63602/.

  9. Wrobel JS, Mayfield JA, Reiber GE. Geographic variation of lower-extremity major amputation in individuals with and without diabetes in the Medicare population. Diabetes Care. 2001;24(5):860–4.

    Article  PubMed  CAS  Google Scholar 

  10. Centers for Disease Control and Prevention (CDC). Prevalence of self-reported cardiovascular disease among persons aged > or =35 years with diabetes – United States, 1997-2005. MMWR Morb Mortal Wkly Rep. 2007;56(43):1129–32.

    Google Scholar 

  11. Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care. 1999;22(1):157–62.

    Article  PubMed  CAS  Google Scholar 

  12. Boulton AJ. The diabetic foot: grand overview, epidemiology and pathogenesis. Diabetes Metab Res Rev. 2008;24 Suppl 1:S3–6.

    Article  PubMed  Google Scholar 

  13. Apelqvist J, Larsson J. What is the most effective way to reduce incidence of amputation in the diabetic foot? Diabetes Metab Res Rev. 2000;16 Suppl 1:S75–83.

    Article  PubMed  Google Scholar 

  14. Margolis DJ, Hoffstad O, Nafash J, Leonard CE, Freeman CP, Hennessy S, et al. Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes. Diabetes Care. 2011;34(11):2363–7.

    Article  PubMed  Google Scholar 

  15. McKinlay JB, Marceau LD, Piccolo RJ. Do doctors contribute to the social patterning of disease? The case of race/ethnic disparities in diabetes mellitus. Med Care Res Rev. 2012;69(2):176–93.

    Article  PubMed  Google Scholar 

  16. Maskarinec G, Grandinetti A, Matsuura G, Sharma S, Mau M, Henderson BE, et al. Diabetes prevalence and body mass index differ by ethnicity: the Multiethnic Cohort. Ethn Dis. 2009;19(1):49–55.

    PubMed  Google Scholar 

  17. Cusi K, Ocampo GL. Unmet needs in Hispanic/Latino patients with type 2 diabetes mellitus. Am J Med. 2011;124(10 Suppl):S2–9.

    Article  PubMed  Google Scholar 

  18. Okosun IS, Liao Y, Rotimi CN, Prewitt TE, Cooper RS. Abdominal adiposity and clustering of multiple metabolic syndrome in White, Black and Hispanic Americans. Ann Epidemiol. 2000;10(5):263–70.

    Article  PubMed  CAS  Google Scholar 

  19. Mainous 3rd AG, Diaz VA, Koopman RJ, Everett CJ. Quality of care for Hispanic adults with diabetes. Fam Med. 2007;39(5):351–6.

    PubMed  Google Scholar 

  20. LeMaster JW, Chanetsa F, Kapp JM, Waterman BM. Racial disparities in diabetes-related preventive care: results from the Missouri Behavioral Risk Factor Surveillance System. Prev Chronic Dis. 2006;3(3):A86.

    PubMed  Google Scholar 

  21. Wendel CS, Shah JH, Duckworth WC, Hoffman RM, Mohler MJ, Murata GH. Racial and ethnic disparities in the control of cardiovascular disease risk factors in Southwest American veterans with type 2 diabetes: the Diabetes Outcomes in Veterans Study. BMC Health Serv Res. 2006;6:58.

    Article  PubMed  Google Scholar 

  22. Dunn JE, Link CL, Felson DT, Crincoli MG, Keysor JJ, McKinlay JB. Prevalence of foot and ankle conditions in a multiethnic community sample of older adults. Am J Epidemiol. 2004;159(5):491–8.

    Article  PubMed  CAS  Google Scholar 

  23. Hall YN. Racial and ethnic disparities in end stage renal disease: access failure. Clin J Am Soc Nephrol. 2012;7(2):196–8.

    Article  PubMed  Google Scholar 

  24. Feinglass J, Rucker-Whitaker C, Lindquist L, McCarthy WJ, Pearce WH. Racial differences in primary and repeat lower extremity amputation: results from a multihospital study. J Vasc Surg. 2005;41(5):823–9.

    Article  PubMed  Google Scholar 

  25. Lavery LA, van Houtum WH, Armstrong DG, Harkless LB, Ashry HR, Walker SC. Mortality following lower extremity amputation in minorities with diabetes mellitus. Diabetes Res Clin Pract. 1997;37(1):41–7.

    Article  PubMed  CAS  Google Scholar 

  26. Holman KH, Henke PK, Dimick JB, Birkmeyer JD. Racial disparities in the use of revascularization before leg amputation in Medicare patients. J Vasc Surg. 2011;54(2):420–6, 426.e1.

    Google Scholar 

  27. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation. 1998;97(5):425–8.

    Article  PubMed  CAS  Google Scholar 

  28. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002;287(19):2570–81.

    Article  PubMed  CAS  Google Scholar 

  29. American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care. 2003;26(12):3333–41.

    Article  Google Scholar 

  30. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998;47(3):457–63.

    Article  PubMed  CAS  Google Scholar 

  31. Geng YJ, Libby P. Progression of atheroma: a struggle between death and procreation. Arterioscler Thromb Vasc Biol. 2002;22(9):1370–80.

    Article  PubMed  CAS  Google Scholar 

  32. Cooper ME. Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet. 1998;352(9123):213–9.

    Article  PubMed  CAS  Google Scholar 

  33. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet. 2000;355(9200):253–9. Erratum in: Lancet 2000;356(9232):860.

    Google Scholar 

  34. Cao Z, Hulthén UL, Allen TJ, Cooper ME. Angiotensin converting enzyme inhibition and calcium antagonism attenuate streptozotocin-diabetes-associated mesenteric vascular hypertrophy independently of their hypotensive action. J Hypertens. 1998;16(6):793–9.

    Article  PubMed  CAS  Google Scholar 

  35. Colwell JA, American Diabetes Association. Aspirin therapy in diabetes. Diabetes Care. 2003;26 Suppl 1:S87–8.

    PubMed  Google Scholar 

  36. Murphy TP, Cutlip DE, Regensteiner JG, Mohler ER, Cohen DJ, Reynolds MR, et al. CLEVER Study Investigators. Supervised exercise versus primary stenting for claudication resulting from aortoiliac peripheral artery disease: six-month outcomes from the claudication: exercise versus endoluminal revascularization (CLEVER) Study. Circulation. 2012;125(1):130–9.

    Google Scholar 

  37. Abularrage CJ, Conrad MF, Hackney LA, Paruchuri V, Crawford RS, Kwolek CJ, et al. Long-term outcomes of diabetic patients undergoing endovascular infrainguinal interventions. J Vasc Surg. 2010;52(2):314–22.e1–4.

    Article  PubMed  Google Scholar 

  38. Panayiotopoulos YP, Tyrrell MR, Owen SE, Reidy JF, Taylor PR. Outcome and cost analysis after femorocrural and femoropedal grafting for critical limb ischaemia. Br J Surg. 1997;84(2):207–12.

    Article  PubMed  CAS  Google Scholar 

  39. Conte MS. Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes. J Vasc Surg. 2010;52(3 Suppl):96S–103.

    Article  PubMed  Google Scholar 

  40. LaMuraglia GM, Conrad MF, Chung T, Hutter M, Watkins MT, Cambria RP. Significant perioperative morbidity accompanies contemporary infrainguinal bypass surgery: an NSQIP report. J Vasc Surg. 2009;50(2):299–304, 304.e1–4.

    Google Scholar 

  41. Meltzer AJ, Shrikhande G, Gallagher KA, Aiello FA, Kahn S, Connolly P, et al. Heart failure is associated with reduced patency after endovascular intervention for symptomatic peripheral arterial disease. J Vasc Surg. 2012;55(2):353–62.

    Article  PubMed  Google Scholar 

  42. Aiello FA, Khan AA, Meltzer AJ, Gallagher KA, McKinsey JF, Schneider DB. Statin therapy is associated with superior clinical outcomes after endovascular treatment of critical limb ischemia. J Vasc Surg. 2012;55(2):371–80.

    Article  PubMed  Google Scholar 

  43. Gallagher KA, Meltzer AJ, Ravin RA, Graham A, Shrikhande G, Connolly PH, et al. Endovascular management as first therapy for chronic total occlusion of the lower extremity arteries: comparison of balloon angioplasty, stenting, and directional atherectomy. J Endovasc Ther. 2011;18(5):624–37. Erratum in: J Endovasc Ther. 2011;18(6):A-5.

    Article  PubMed  Google Scholar 

  44. Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26(3):517–38. Erratum in: J Vasc Surg 2001;33(4):805.

    Article  PubMed  CAS  Google Scholar 

  45. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, TASC II Working Group. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007;45(Suppl S):S5–67.

    Article  PubMed  Google Scholar 

  46. Conte MS, Geraghty PJ, Bradbury AW, Hevelone ND, Lipsitz SR, Moneta GL, et al. Suggested objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia. J Vasc Surg. 2009;50(6):1462–73.e1–3.

    Article  PubMed  Google Scholar 

  47. Sprengers RW, Teraa M, Moll FL, de Wit GA, van der Graaf Y, Verhaar MC; JUVENTAS Study Group; SMART Study Group. Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment. J Vasc Surg. 2010;52(4):843–9, 849.e1.

    Google Scholar 

  48. Landry GJ. Functional outcome of critical limb ischemia. J Vasc Surg. 2007;45(Suppl A):A141–8.

    Article  PubMed  Google Scholar 

  49. Svensson H, Apelqvist J, Larsson J, Lindholm E, Eneroth M. Minor amputation in patients with diabetes mellitus and severe foot ulcers achieves good outcomes. J Wound Care. 2011;20(6):261–2, 264, 266 passim.

    Google Scholar 

  50. Barshes NR, Menard MT, Nguyen LL, Bafford R, Ozaki CK, Belkin M. Infrainguinal bypass is associated with lower perioperative mortality than major amputation in high-risk surgical candidates. J Vasc Surg. 2011;53(5):1251–9.e1.

    Article  PubMed  Google Scholar 

  51. Driver VR, Fabbi M, Lavery LA, Gibbons G. The costs of diabetic foot: the economic case for the limb salvage team. J Vasc Surg. 2010;52(3 Suppl):17S–22. Erratum in: J Vasc Surg. 2010;52(6):1751.

    Article  PubMed  Google Scholar 

  52. LoGerfo FW, Gibbons GW, Pomposelli FB Jr, Campbell DR, Miller A, Freeman DV, Quist WC. Trends in the care of the diabetic foot. Expanded role of arterial reconstruction. Arch Surg. 1992;127(5):617–20; discussion 620–1.

    Google Scholar 

  53. Gibbons GW, Marcaccio Jr EJ, Burgess AM, Pomposelli Jr FB, Freeman DV, Campbell DR, et al. Improved quality of diabetic foot care, 1984 vs 1990. Reduced length of stay and costs, insufficient reimbursement. Arch Surg. 1993;128(5):576–81.

    Article  PubMed  CAS  Google Scholar 

  54. Fitzgerald RH, Mills JL, Joseph W, Armstrong DG. The diabetic rapid response acute foot team: 7 essential skills for targeted limb salvage. Eplasty. 2009;9:e15.

    PubMed  Google Scholar 

  55. Rogers LC, Andros G, Caporusso J, Harkless LB, Mills Sr JL, Armstrong DG. Toe and flow: essential components and structure of the amputation prevention team. J Vasc Surg. 2010;52(3 Suppl):23S–7.

    Article  PubMed  Google Scholar 

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Correspondence to Rishi Kundi M.D. .

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Kundi, R., Meltzer, A.J., Bajakian, D. (2012). General Considerations in the Diabetic Patient with Peripheral Vascular Disease. In: Shrikhande, G., McKinsey, J. (eds) Diabetes and Peripheral Vascular Disease. Contemporary Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-158-5_1

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  • DOI: https://doi.org/10.1007/978-1-62703-158-5_1

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