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Stem Cell Applications for the Treatment of Gastrointestinal System Diseases

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Regenerative Medicine and Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Gastrointestinal system is formed by organs with complex morphology and functions. Digestive tract is not a sterile medium and is exposed to external environment aggressions. As a result, its diseases are complex and encompass a broad spectrum of pathogenic mechanisms and their treatment is often challenging and frequently incurable or chronicity-tending processes are found. In this scenario, stem cells with their differentiation potential and encouraging properties could be helpful. Nowadays Stem Cells have yielded promising results in preclinical studies, some approaches have started clinical development and registered clinical trials are exponentially increasing every year. In 2011, the most advanced programs, involving Crohn’s disease and fistulous disease, have reached phase III of development. Other tested diseases include ulcerative colitis, fecal incontinence or celiac disease. If the preliminary results are confirmed, we think that this therapy may become a clinical reality in the near future. In this chapter, we summarize Stem Cells potential benefits, the current experience and the future perspectives in gastrointestinal system diseases.

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Abbreviations

SCs:

Stem Cells

ESCs:

Embryonic Stem Cells

ASs:

Adult Stem cells

iPS:

Induced Pluripotent Stem

BM-MSCs:

Bone Marrow derived Mesenchymal Stem Cells

MAPCS:

Multipotent Adult Progenitor Cells

ASCs:

Adipose derived Stem Cells

HSCs:

Hematopoietic Stem Cells

GISCs:

GastroIntestinal Stem Cells

LPCs:

Liver Progenitor Cells

EPCs:

Endothelial Progenitor Cells

CBC:

Cript Base Columnar cells

BMSC:

Bone Marrow Stem Cells

CDAI:

Crohn’s Disease Activity Index

IBDQ:

Inflammatory Bowel Disease Questionnaire

BM-MNCs:

Bone Marrow Mononuclear Cells

SVF:

Stromal Vascular Fraction from lipoaspirate

PDSCs:

Placental Derived Stem Cells

U-MSCs:

Umbilical derived Mesenchymal Stem Cells

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Acknowledgments

The authors would like to express their gratitude to all the staff of the Stem Cell Therapy Laboratory of “La Paz” University Hospital (Madrid, Spain), to staff of Investigation Institute IdiPAZ (Madrid, Spain) and of both General and Digestive Surgery Department from “La Paz” University Hospital and “Nuestra Señora de Sonsoles” Hospital (Avila, Spain). We also would like to acknowledge our families for their continuous support during drafting of this chapter.

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Authors and Affiliations

  1. General and Digestive Tract Surgery Department, Hospital “Nuestra Señora de Sonsoles”, Avenida de Juan Carlos I S/N, 05004, Avila, Spain

    Jacobo Trebol Lopez

  2. Laboratorio de Terapia Celular, 2ª Planta Edificio de Investigación y Desarrollo, Hospital Universitario La Paz, Paseo de la Castellana nº 261, 28946, Madrid, Spain

    Jacobo Trebol Lopez

  3. General and Digestive Tract Surgery Department and Cell Therapy Laboratory, Investigation Institute IdiPAZ, University Hospital “La Paz”, Madrid, Spain

    Tihomir Georgiev-Hristov

  4. Cell Therapy Laboratory, Investigation Institute IdiPAZ, Autonomous University, Madrid, Spain

    Jacobo Trebol Lopez, Mariano García-Arranz & Damián García-Olmo

  5. Head of Colorectal Surgery, General and Digestive Tract Surgery Department, University Hospital “La Paz”, Madrid, Spain

    Damián García-Olmo

  6. Associate Proffesor, Surgery Department,, Autonomous University, Madrid, Spain

    Mariano García-Arranz & Damián García-Olmo

Authors
  1. Jacobo Trebol Lopez
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  2. Tihomir Georgiev-Hristov
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  3. Mariano García-Arranz
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  4. Damián García-Olmo
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Corresponding author

Correspondence to Jacobo Trebol Lopez .

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Editors and Affiliations

  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Trebol Lopez, J., Georgiev-Hristov, T., García-Arranz, M., García-Olmo, D. (2013). Stem Cell Applications for the Treatment of Gastrointestinal System Diseases . In: Baharvand, H., Aghdami, N. (eds) Regenerative Medicine and Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-098-4_12

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