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Obesity and Acute Lung Injury

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Book cover Obesity and Lung Disease

Part of the book series: Respiratory Medicine ((RM,volume 19))

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Abstract

Acute lung injury (ALI) is a common clinical inflammatory syndrome ­associated with severe acute hypoxemic respiratory with a case fatality of 30–40%. Although counterintuitive, several studies now suggest that the survival of obese and extremely obese critically ill patients with ALI (as well as obese critically ill patients in general) is equal to or better than their lean critically ill counterparts. The mechanisms underlying these findings are not yet clear but may be related to obesity-associated alterations of the host inflammatory response or to decreased susceptibility to ventilator-induced lung injury in these patients. Despite possible survival benefits afforded by obesity in ALI, studies do suggest that obese patients may have longer durations of ventilation and ICU stays. This information is important for clinicians to consider when discussing prognosis and expectations with critically ill patients and their families.

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Authors and Affiliations

  1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue HSRF 222, Burlington, VT, 05405, USA

    Renee D. Stapleton M.D., Ph.D.

  2. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue Given E407A, Burlington, VT, 05405, USA

    Benjamin T. Suratt M.D.

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Correspondence to Benjamin T. Suratt M.D. .

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  1. , Pulmonary and Critical Care Medicine, University of Vermont College of Medicin, 89 Beaumont Ave., Burlington, 05405, Vermont, USA

    Anne E. Dixon

  2. , Clinical Development Medical Affairs, Respiratory Boehringer Ingelheim Pharmac, N/A, Ridgefield, 06877, Connecticut, USA

    Emmanuelle M. Clerisme-Beaty

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Stapleton, R.D., Suratt, B.T. (2013). Obesity and Acute Lung Injury. In: Dixon, A., Clerisme-Beaty, E. (eds) Obesity and Lung Disease. Respiratory Medicine, vol 19. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-053-3_10

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  • DOI: https://doi.org/10.1007/978-1-62703-053-3_10

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-052-6

  • Online ISBN: 978-1-62703-053-3

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