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Magnesium Intake, Genetic Variants, and Diabetes Risk

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Magnesium in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Abstract

Type 2 diabetes mellitus (DM) is a major global public health burden, affecting more than 170 million individuals worldwide [1]. Overall, it is estimated that the prevalence of diabetes will increase by 42 % among adults living in developed countries and by 170 % among adults in developing countries by 2025 [2, 3]. More alarmingly, by the time type 2 DM is diagnosed, most individuals have developed complications such as peripheral artery disease, renal failure, and neuropathy, and the vast majority of diabetic patients die of these complications [4]. Given the rising global burden of type 2 DM and its devastating complications, there is a great urgency to develop effective strategies to curb the epidemic by identifying individuals at high risk and optimizing prevention and early treatment. The predisposition to type 2 DM varies widely in the population and is largely determined by complex gene–environment interactions.

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Abbreviations

Type 2 DM:

Type 2 diabetes mellitus

TRPM6:

Transient receptor potential membrane melastatin 6

TRPM7:

Transient receptor potential membrane melastatin 7

PLCN-1:

Paracellin-1

SLC41A1:

Solute carrier family 41 member 1

MRS2:

Mitochondrial RNA splicing 2

FXYD2:

Sodium-potassium-ATPase, gamma-1 polypeptide

SLC12A3:

Solute carrier family 12 (sodium/chloride transporter)

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Authors and Affiliations

  1. Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA, 02148, USA

    Yiqing Song M.D., Sc.D. & Lu Wang M.D., Ph.D.

  2. Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Cuilin Zhang M.D., Ph.D.

  3. Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Nashville, TN, USA

    Qi Dai M.D., Ph.D.

  4. UCLA Departments of Epidemiology, Medicine, and Obstetrics & Gynecology, Center for Metabolic Disease Prevention, 650 Charles E. Young Drive South, CHS 71-254, 951772, Los Angeles, CA, 90095, USA

    Simin Liu M.D., Sc.D., MPH (Professor of Epidemiology and Medicine)

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  1. Yiqing Song M.D., Sc.D.
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  2. Cuilin Zhang M.D., Ph.D.
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  3. Lu Wang M.D., Ph.D.
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  4. Qi Dai M.D., Ph.D.
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  5. Simin Liu M.D., Sc.D., MPH
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Correspondence to Yiqing Song M.D., Sc.D. .

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Editors and Affiliations

  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Song, Y., Zhang, C., Wang, L., Dai, Q., Liu, S. (2013). Magnesium Intake, Genetic Variants, and Diabetes Risk. In: Watson, R., Preedy, V., Zibadi, S. (eds) Magnesium in Human Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-044-1_6

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