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Magnesium and Its Interdependency with Other Cations in Acute and Chronic Stressor States

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Magnesium in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Abstract

Mg2+ and Ca2+ are major divalent intracellular cations. Mg2+ is integral to a myriad of enzymatic reactions and physiologic responses, especially in tissues such as the heart, where metabolic activity and ATP consumption are high [1]. In addition, there are intricate interdependencies between Mg2+ and Ca2+ and other cations. Numerous examples of the interplay that exists between Mg2+, Ca2+, and K+ have been well recognized. Herein, we focus specifically on several inseparable interconnections involving Mg2+ and those cations which are clinically relevant to the heart during acute and chronic stressor states, wherein neurohormonal activation involving the adrenergic and renin-angiotensin-aldosterone systems unmasks their interdependency.

This work was supported, in part, by NIH grants R01-HL73043 and R01-HL90867 (KTW). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Authors have no conflicts of interest to disclose.

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Abbreviations

CHF:

Congestive heart failure

PTH:

Parathyroid hormone

SHPT:

Secondary hyperparathyroidism

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Authors and Affiliations

  1. Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Coleman College of Medicine Bldg., Suite A312, 956 Court Avenue, Memphis, TN, 38163, USA

    Babatunde O. Komolafe M.D., M. Usman Khan M.D., Rami N. Khouzam M.D., Dwight A. Dishmon M.D., Kevin P. Newman M.D., Syamal K. Bhattacharya Ph.D. & Karl T. Weber M.D.

  2. Division of Cardiovascular Diseases, University of Tennessee Health Science Center and Veterans Affairs Medical Center, Memphis, TN, USA

    Jesse E. McGee M.D.

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  1. Babatunde O. Komolafe M.D.
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Correspondence to Karl T. Weber M.D. .

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  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Komolafe, B.O. et al. (2013). Magnesium and Its Interdependency with Other Cations in Acute and Chronic Stressor States. In: Watson, R., Preedy, V., Zibadi, S. (eds) Magnesium in Human Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-044-1_17

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