Abstract
Neurology deals with the study and management of disorders of the nervous system. Considerable research is in progress in basic neurosciences and clinical neurology. The management is mostly medical. Many neurological disorders require surgical intervention, and the closely related specialty of surgical neurology or neurosurgery will also be considered in this chapter. There is a considerable scope for application of nanobiotechnology in neurology and hence the term nanoneurology (Jain 2009a). Nanobiotechnology has been applied for neurophysiological studies, diagnosis, neuropharmacology, and refinement of surgical tools. Neuroprotection is an important objective in treatment of diseases of the central nervous system (CNS).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Anderson SA, Glod J, Arbab AS, et al. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood 2005;105:420–5.
Barbu E, Molnà r E, Tsibouklis J, et al. The potential for nanoparticle-based drug delivery to the brain: overcoming the blood–brain barrier. Expert Opin Drug Deliv 2009;6:553–65.
Bharali DJ, Klejbor I, Stachowiak EK, et al. Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain. 2005;102:11539–44.
Callera F, de Melo C. Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+ cells’ migration into the injured site. Stem Cells and Development 2007;16:461–466.
Ding H, Inoue S, Ljubimov AV, et al. Inhibition of brain tumor growth by intravenous poly(β-Lmalic acid) nanobioconjugate with pH-dependent drug release. Proc Natl Acad Sci U S A 2010;107: 18143–8.
Ellis-Behnke RG, Liang YX, You SW, et al. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A 2006;103:5054–9.
Jain KK. Use of nanoparticles for drug delivery in glioblastoma multiforme. Expert Rev Neurother 2007a;7:363–72.
Jain KK. Current Status and Future Prospects of Nanoneurology. J Nanoneuroscience 2009a;1:56–64.
Jain KK. Handbook of Neuroprotection. Springer, New York, 2011.
Jain KK. Drug Delivery in Central Nervous System Disorders: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, 2012e.
Jain KK. Nanobiotechnology-based strategies for crossing the blood–brain barrier. Nanomedicine (Lond) 2012f July (in press).
Jain KK. Regenerative Therapy for Central Nervous System Trauma, Chapter 25, In, Steinhoff G (ed) Regenerative Medicine, 2nd ed, Springer, London, 2012g.
Kang C, Yuan X, Zhong Y, et al. Growth Inhibition Against Intracranial C6 Glioma Cells by Stereotactic Delivery of BCNU by Controlled Release from poly(D,L-lactic acid) Nanoparticles. Technol Cancer Res Treat 2009;8:61–70.
Kim W, Ng JK, Kunitake ME, et al. Interfacing silicon nanowires with mammalian cells. J Am Chem Soc 2007;129:7228–9.
Kreuter J, Gelperina S. Use of nanoparticles for cerebral cancer. Tumori 2008;94:271–7.
Larsen A, Kolind K, Pedersen DS, et al. Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury. Histochem Cell Biol 2008;130:681–92.
Liopo AV, Stewart MP, Hudson J, et al. Biocompatibility of Native and Functionalized Single-Walled Carbon Nanotubes for Neuronal Interface. J Nanosci Nanotechnol 2006;6:1365–1374.
Llinas RR, Walton KD, Nakao M, et al. Neuro-vascular central nervous recording/stimulating system: Using nanotechnology probes. Journal of Nanoparticle Research 2005;7:111–127.
Lu W, Sun Q, Wan J, She Z, Jiang XG. Cationic Albumin-Conjugated Pegylated Nanoparticles Allow Gene Delivery into Brain Tumors via Intravenous Administration. Cancer Res 2006;66:11878–87.
Martin-Banderas L, Holgado MA, Venero JL, et al. Nanostructures for drug delivery to the brain. Curr Med Chem 2011;18:5303–21.
Misra N, Martinez JA, Huang SC, et al. Bioelectronic silicon nanowire devices using functional membrane proteins. Proc Natl Acad Sci U S A 2009;106:13780–4.
Neuwelt EA, Varallyay P, Bago AG, et al. Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours. Neuropathology and Applied Neurobiology 2004;30:456–71.
Panseri S, Cunha C, Lowery J, et al. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnology 2008;8:39.
Pappas TC, Wickramanyake WM, Jan E, et al. Nanoscale Engineering of a Cellular Interface with Semiconductor Nanoparticle Films for Photoelectric Stimulation of Neurons. Nano Lett 2007;7:513–9.
Petry KG, Boiziau C, Dousset V, Brochet B. Magnetic resonance imaging of human brain macrophage infiltration. Neurotherapeutics 2007;4:434–42.
Posadas I, Guerra FJ, Ceña V. Nonviral vectors for the delivery of small interfering RNAs to the CNS. Nanomedicine 2010;5:1219–36.
Qiao Y, Chen J, Guo X, et al. Fabrication of nanoelectrodes for neurophysiology: cathodic electrophoretic paint insulation and focused ion beam milling. Nanotechnology 2005;16:1598–1602.
Qing Q, Pal SK, Tian B, et al. Nanowire transistor arrays for mapping neural circuits in acute brain slices. Proc Natl Acad Sci U S A 2010;107:1882–7.
Reddy MK, Wu L, Kou W, et al. Superoxide Dismutase-Loaded PLGA Nanoparticles Protect Cultured Human Neurons Under Oxidative Stress. Appl Biochem Biotechnol 2008;151:565–77.
Rocha R, Zhou Y, Kundu S, et al. In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis. J Nanobiotechnol 2011;9:5.
Roy S, Glueckert R, Johnston AH, et al. Strategies for drug delivery to the human inner ear by multifunctional nanoparticles. Nanomedicine (Lond) 2012;7:55–63.
Seil JT, Webster TJ. Electrically active nanomaterials as improved neural tissue regeneration scaffolds. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2010;2:635–47.
Shea TB, Ortiz D, Nicolosi RJ, et al. Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta. J Alzheimer’s Dis 2005;7:297–301.
Shi Y, Kim S, Huff TB, et al. Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles. Nat Nanotech 2010;5:80–7.
Silva GA. Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system. Ann NY Acad Sci 2010;1199:221–30.
Sprintz M, Benedetti C, Ferrari M. Applied nanotechnology for the management of breakthrough cancer pain. Minerva Anestesiol 2005;71:419–23.
Stabenfeldt SE, Irons HR, Laplaca MC. Stem cells and bioactive scaffolds as a treatment for traumatic brain injury. Curr Stem Cell Res Ther 2011;6:208–20.
Suh WH, Suslick KS, Stucky GD, Suh YH. Nanotechnology, nanotoxicology, and neuroscience. Prog Neurobiol 2009;87:133–70.
Sykova E, Jendelova P. In vivo tracking of stem cells in brain and spinal cord injury. Prog Brain Res 2007;161C:367–383.
Tosi G, Costantino L, Ruozi B, et al. Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opinion on Drug Delivery 2008;5:155–74.
Veiseh O, Sun C, Fang C, et al. Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood–brain barrier. Cancer Res 2009;69:6200–7.
Webber MJ, Kessler JA, Stupp SI. Emerging peptide nanomedicine to regenerate tissues and organs. J Intern Med 2010;267:71–88.
Yanik MF, Cinar H, Cinar HN, et al. Neurosurgery: Functional regeneration after laser axotomy. Nature 2004;432:822.
Yoo SI, Yang M, Brender JR, et al. Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. Angew Chem Int Ed Engl 2011;50:5110–5.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jain, K.K. (2012). Nanoneurology. In: The Handbook of Nanomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-983-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-61779-983-9_9
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-982-2
Online ISBN: 978-1-61779-983-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)