Skip to main content

Angina

  • Chapter
  • First Online:
Book cover Cardiac Drug Therapy

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 3467 Accesses

Abstract

Angina is a pain in the chest or adjacent areas caused by severe, but temporary, lack of blood (ischemia) to a segment of the heart muscle, hence the term myocardial ischemia. For stable angina, the most important feature is the causation of pain by a particular exertional activity and relief within minutes of cessation of the precipitating activity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abrams J. Interval therapy to avoid nitrate tolerance: paradise regained. Am J Cardiol. 1989;64:931.

    Article  CAS  PubMed  Google Scholar 

  • Cairns JA, Gent M, Singer J, et al. Aspirin, sulfinpyrazone or both in unstable angina. N Engl J Med. 1985;313:1369.

    Article  CAS  PubMed  Google Scholar 

  • Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495–504 [Erratum, N Engl J Med 2006;354:778.].

    Article  CAS  PubMed  Google Scholar 

  • CAPRICORN investigators. Effect of carvedilol on outcome after myocardial infarction in patients with LV dysfunction. Lancet. 2001;357:1385.

    Article  Google Scholar 

  • Cohn PF. Total ischemic burden: pathophysiology and prognosis. Am J Cardiol. 1987;59:3C.

    Article  CAS  PubMed  Google Scholar 

  • COURAGE Boden WE, O’Rourke RA, Teo KK, et al. for the COURAGE trial research. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503–1516.

    Google Scholar 

  • Cruickshank JM. Beta-blockers continue to surprise us. Eur Heart J. 2000;21:354.

    Article  CAS  PubMed  Google Scholar 

  • Elkayam U. Tolerance to organic nitrates: evidence, mechanisms, clinical relevance and strategies for prevention. Ann Intern Med. 1991;114:667.

    Article  CAS  PubMed  Google Scholar 

  • Fihn SD, Blankenship JC, Alexander KP, et al. ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014;28:2014. doi:10.1016/j.jacc.2014.07.017.

    Google Scholar 

  • George S, Cockburn J, Clayton TC. Long-term follow-up of elective chronic total coronary occlusion angioplasty analysis from the U.K. Central Cardiac Audit Database. J Am Coll Cardiol. 2014;64:235–43.

    Article  PubMed  Google Scholar 

  • Gottlieb SO, Weisfeldt ML, Ouyang P, et al. Silent ischemia as a marker for early unfavorable outcomes in patients with unstable angina. N Engl J Med. 1986;314:1214.

    Article  CAS  PubMed  Google Scholar 

  • Grosser T, Fries S, Lawson JA, et al. Drug resistance and pseudoresistance an unintended consequence of enteric coating Aspirin. Circulation. 2013;127:377–85.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hobl E, Stimlfl T, Ebner J, et al. Morphine decreases clopidogrel concentrations and effects. A randomized double—blind placebo-controlled trial. J Am Coll Cardiol. 2014;63(7):630–5.

    Article  CAS  PubMed  Google Scholar 

  • Juul Moller S, Edvardsson N, Jhnmatz B, et al. Double blind trial of aspirin in primary prevention of myocardial infarction in patients with stable angina pectoris. Lancet. 1992;340:1421.

    Article  CAS  PubMed  Google Scholar 

  • Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ. 2009;180:713–8.

    Article  PubMed Central  PubMed  Google Scholar 

  • Khan MG. Angina. In: Heart disease, diagnosis and therapy. Totowa, NJ: Humana Press, 2005, p. 55.

    Google Scholar 

  • Lewis HD, Davis JW, Archibald DG, et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309:396.

    Article  PubMed  Google Scholar 

  • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366:9–19.

    Article  CAS  PubMed  Google Scholar 

  • Miwa K, Kambara H, Kawai C. Effect of aspirin in large doses on attacks of variant angina. Am Heart J. 1983;105:351.

    Article  CAS  PubMed  Google Scholar 

  • Nademanee K, Intarachot V, Josephson MA, et al. Prognostic significance of silent myocardial ischemia in patients with unstable angina. J Am Coll Cardiol. 1987;10:1.

    Article  CAS  PubMed  Google Scholar 

  • Norwegian MultiCenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med. 1981;304:801.

    Article  Google Scholar 

  • O’Rourke RA. Optimal medical therapy is a proven option for chronic stable angina. J Am Coll Cardiol. 2008a;52:905–7.

    Article  PubMed  Google Scholar 

  • Packer M, Le WH, Kessler P, et al. Induction of nitrate tolerance in heart failure by continuous infusion of nitroglycerin and reversal of tolerance by N-acetylcysteine, a sulfhydryl donor (abstract). J Am Coll Cardiol. 1986;7:27A.

    Article  Google Scholar 

  • Peterson ED, Rumsfeld JS. Finding the courage to reconsider medical therapy for stable angina. N Engl J Med. 2008;359:751–3.

    Article  CAS  PubMed  Google Scholar 

  • PRAISE, Packer M, O’Connor CM, Ghoul JK, et al. Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation study group. N Engl J Med. 1996;335:1107.

    Article  CAS  PubMed  Google Scholar 

  • Rudolph W. Tolerance development during isosorbide dinitrate treatment: can it be circumvented? Z Kardiol. 1983;72:195.

    PubMed  Google Scholar 

  • Schömig A, Mehilli J, de Waha A, et al. A meta-analysis of 17 randomized trials of a percutaneous coronary intervention-based strategy in patients with stable coronary artery disease. J Am Coll Cardiol. 2008;52:894–904.

    Article  PubMed  Google Scholar 

  • Sharpe N, Coxon R, Webster M, et al. Hemodynamic effects of intermittent transdermal nitroglycerin in chronic congestive heart failure. Am J Cardiol. 1987;59:895.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Khan, M.G. (2015). Angina. In: Cardiac Drug Therapy. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-962-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-61779-962-4_10

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-961-7

  • Online ISBN: 978-1-61779-962-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics