Clinical Testing of Endothelial Function in Erectile Dysfunction

  • Titte R. SrinivasEmail author
  • Mark S. Segal
Part of the Current Clinical Urology book series (CCU)


Understanding the physiology of endothelial function in health and disease is critical to understanding the physiologic substrate of erectile dysfunction and cardiovascular health in men. Erectile dysfunction is increasingly recognized as a marker for cardiovascular disease in men. The recent availability of clinically applicable methods to study endothelial dysfunction (reactive hyperemia) and vascular stiffness (augmentation index) has enhanced the ability of the clinician to incorporate the study of vascular health in the clinic. We discuss and review techniques and biomarkers that are applicable at the bedside in the context of diagnosis, treatment, and follow-up of erectile dysfunction. We articulate a framework for diagnosis, treatment, and future clinical investigation in this growing field.


Endothelial Function Erectile Dysfunction Reactive Hyperemia Augmentation Index Vascular Health 
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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of Nephrology and HypertensionGlickman Urologic and Kidney Institute, Cleveland ClinicClevelandUSA
  2. 2.Division of Nephrology, Hypertension and TransplantationUniversity of FloridaGainsvilleUSA

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