Abstract
Peyronie’s disease is a common potency-threatening condition of male sexual dysfunction, occurring in 3–8% of men. While typically thought to be a result of injury during sexual activity, the underlying cause of Peyronie’s disease can vary and is not known in every situation. Clinical presentation may include a curved or bent penis, a palpable penile scar or plaque, complaints of decreased penile length, diminished penile stretch, less rigidity, penile numbness, and erectile dysfunction. Numerous advances have been made in understanding the mechanisms involving Peyronie’s disease, while improved diagnostic techniques, including penile duplex Doppler ultrasonography, and advanced therapeutic interventions, including intralesional therapy, surgical grafting techniques, and advanced prosthetics have allowed for the successful treatment of this significant medical problem. This chapter reviews the contemporary state of knowledge of Peyronie’s disease, focusing on the role of diagnostics, therapeutic alternatives and offers an algorithmic approach for the management of this disorder.
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References
Serefoglu EC, Hellstrom WJ. Treatment of Peyronie’s disease: 2012 update. Curr Urol Rep. 2011;12(6):444–52. http://dx.doi.org/10.1007/s11934-011-0212-2aaaa. Accessed 5 Aug 2011.
Nugteren HM, Nijman JM, de Jong IJ, van Driel MF. The association between Peyronie’s and Dupuytren’s disease. Int J Impot Res. 2011;23(4):142–5.
Casabé A, Bechara A, Cheliz G, De Bonis W, Rey H. Risk factors of Peyronie’s disease. What does our clinical experience show? J Sex Med. 2011;8(2):518–23.
Faix A, Lapray JF, Callede O, Maubon A, Lanfrey K. Magnetic resonance imaging (MRI) of sexual intercourse: second experience in missionary position and initial experience in posterior position. J Sex Marital Ther. 2002;28 Suppl 1:63–76.
Hellstrom WJ, Bivalacqua TJ. Peyronie’s disease: etiology, medical, and surgical therapy. J Androl. 2000; 21(3):347–54.
Hakim LS, Platt M. The couple’s disease: finding a cure for your ‘lost’ love life. NY: DHP Publishers; 2002.
Mulhall JP, Alex B, Choi JM. Predicting delay in presentation in men with Peyronie’s disease. J Sex Med. 2010;7(6):2226–30.
Smith JF, Brant WO, Fradet V, Shindel AW, et al. Penile sonographic and clinical characteristics in men with Peyronie’s disease. J Sex Med. 2009;6(10): 2858–67.
Smith JF, Walsh TJ, Conti SL, Turek P, Lue T. Risk factors for emotional and relationship problems in Peyronie’s disease. J Sex Med. 2008;5(9):2179–84.
Ralph D, Gonzalez-Cadavid N, Mirone V, Perovic S, Sohn M, Usta M, Levine L. The management of Peyronie’s disease: evidence-based 2010 guidelines. J Sex Med. 2010;7(7):2359–74.
Gur S, Limin M, Hellstrom WJ. Current status and new developments in Peyronie’s disease: medical, minimally invasive and surgical treatment options. Expert Opin Pharmacother. 2011;12(6):931–44.
Safarinejad MR, Asgari MA, Hosseini SY, Dadkhah F. A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie’s disease. BJU Int. 2010;106(2):240–8.
Gonzalez-Cadavid NF, Rajfer J. Treatment of Peyronie’s disease with PDE5 inhibitors: an antifibrotic strategy. Nat Rev Urol. 2010;7(4): 215–21.
Chung E, Deyoung L, Brock GB. The role of PDE5 inhibitors in penile septal scar remodeling: assessment of clinical and radiological outcomes. J Sex Med. 2011;8(5):1472–7.
Cavallini G, Biagiotti G, Lo Giudice C. Association between Peyronie’s disease and low serum testosterone levels: detection and therapeutic considerations. J Androl. 2011. http://www.andrologyjournal.org/cgi/rapidpdf/jandrol.111.012948v1. Accessed 5 Aug 2011.
Greenfield JM, Shah SJ, Levine LA. Verapamil versus saline in electromotive drug administration for Peyronie’s disease: a double-blind, placebo controlled trial. J Urol. 2007;177(3):972–5.
Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, et al. Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie’s disease. J Urol. 2006;176(1):394–8.
Kendirci M, Usta MF, Matern RV, Nowfar S, et al. The impact of intralesional interferon alpha-2b injection therapy on penile hemodynamics in men with Peyronie’s disease. J Sex Med. 2005;2(5):709–15.
Vardi Y, Levine LA, Chen J, Hatzimouratidis K, Sohn M. Is there a place for conservative treatment in Peyronie’s disease? J Sex Med. 2009;6(4):903–9.
De Berardinis E, Busetto GM, Antonini G, Giovannone R, Gentile V. Extracorporeal shock wave therapy in the treatment of Peyronie’s disease: long-term results. Arch Ital Urol Androl. 2010;82(2):128–33.
Chitale S, Morsey M, Swift L, Sethia K. Limited shock wave therapy vs. sham treatment in men with Peyronie’s disease: results of a prospective randomized controlled double-blind trial. BJU Int. 2010;106(9):1352–6.
Rahim AA, Giraffe G, Rahim TA, Dixon M, et al. The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU Int. 2010;106(8):1178–80.
Levine LA, Newell M, Taylor FL. Penile traction therapy for treatment of Peyronie’s disease: a single-center pilot study. J Sex Med. 2008;5(6):1468–73.
Mulhall J, Anderson M, Parker M. A surgical algorithm for men with combined Peyronie’s disease and erectile dysfunction: functional and satisfaction outcomes. J Sex Med. 2005;2(1):132–8.
Richardson B, Pinsk MR, Hellstrom WJ. Incision and grafting for severe Peyronie’s disease. J Sex Med. 2009;6(8):2084–7.
Lentz AC, Carson 3rd CC. Peyronie’s surgery: graft choices and outcomes. Curr Urol Rep. 2009;10(6): 460–7.
Chung E, Clendenin E, Lesser L, Brock G. Five-year follow-up of Peyronie’s graft surgery: outcomes and patient satisfaction. J Sex Med. 2011;8(2):594–600.
Levine LA, Demetrious RJ. A surgical algorithm for penile prosthesis placement in men with erectile failure and Peyronie’s disease. Int J Impot Res. 2000; 12(3):147–51.
Levine LA, Benso J, Hoover C. Inflatable penile prosthesis placement in men with Peyronie’s disease and drug-resistant erectile dysfunction: a single-center study. J Sex Med. 2010;7(11):3775–83.
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Hakim, L.S. (2012). Evaluation and Treatment of Peyronie’s Disease. In: Shoskes, D. (eds) Urological Men’s Health. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-900-6_10
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DOI: https://doi.org/10.1007/978-1-61779-900-6_10
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