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The Developmental Origins of Chronic Disease in Later Life

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Nutritional Health

Part of the book series: Nutrition and Health ((NH))

Abstract

The recent discovery that people who develop coronary heart disease (CHD) grew differently compared to other people during fetal life and childhood has led to a new “developmental” model for chronic disease [1, 2]. The model proposes that nutrition during fetal life, infancy, and early childhood establishes functional capacity, metabolic competence, and responses to the later environment by changing gene expression [3]. There is now clear evidence that the pace and pathway of early growth is a major risk factor for the development of chronic disease in adult life.

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Authors and Affiliations

  1. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Mailpoint 95, Southampton, SO16 6YD, UK

    David J. P. Barker MD, PhD, FRS

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  1. David J. P. Barker MD, PhD, FRS
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Correspondence to David J. P. Barker MD, PhD, FRS .

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Editors and Affiliations

  1. Centre for Science, Athabasca University, Athabasca, T9S 3A3, Alberta, Canada

    Norman J. Temple

  2. Department of Biology, Winona State University, Winona, 54603, Minnesota, USA

    Ted Wilson

  3. School of Public Health, Division of Epidemiology and Community H, University of Minnesota, 1300 South Second St., Minneapolis, 55454, USA

    David R. Jacobs, Jr.

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Barker, D.J.P. (2012). The Developmental Origins of Chronic Disease in Later Life. In: Temple, N., Wilson, T., Jacobs, Jr., D. (eds) Nutritional Health. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-894-8_4

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