Abstract
Epidemiological studies highlight the rising prevalence of vitamin D deficiency and insufficiency and its association with poor respiratory health, including asthmatic disease. These and further studies have increased interest in the immunomodulatory properties of vitamin D beyond its well-defined role in bone health and calcium homeostasis. The vitamin D receptor (VDR) is ubiquitously expressed in cells of the immune system including activated T cells. This chapter discusses recent evidence that vitamin D promotes a specific T cell subset, namely regulatory T cells, which have a potentially vital role in the regulation of inappropriate disease-causing immune responses in the lung. Emerging clinical data on the capacity of vitamin D to promote both IL-10- and FoxP3-expressing cells are also discussed.
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Urry, Z., Dimeloe, S., Hawrylowicz, C.M. (2012). Vitamin D and Regulatory T Cells. In: Litonjua, A. (eds) Vitamin D and the Lung. Respiratory Medicine, vol 3. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-888-7_5
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