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Vitamin D and the Lung pp 85–101Cite as

Vitamin D and Regulatory T Cells

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Part of the book series: Respiratory Medicine ((RM,volume 3))

Abstract

Epidemiological studies highlight the rising prevalence of vitamin D deficiency and insufficiency and its association with poor respiratory health, including asthmatic disease. These and further studies have increased interest in the immunomodulatory properties of vitamin D beyond its well-defined role in bone health and calcium homeostasis. The vitamin D receptor (VDR) is ubiquitously expressed in cells of the immune system including activated T cells. This chapter discusses recent evidence that vitamin D promotes a specific T cell subset, namely regulatory T cells, which have a potentially vital role in the regulation of inappropriate disease-causing immune responses in the lung. Emerging clinical data on the capacity of vitamin D to promote both IL-10- and FoxP3-expressing cells are also discussed.

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Authors and Affiliations

  1. Medical Research Council and Asthma United Kingdom Centre in Allergic Mechanisms of Asthma, King’s College London, London, UK

    Zoë Urry, Sarah Dimeloe & Catherine M. Hawrylowicz

  2. Kings College London, Guy’s Hospital, 5th Floor Tower Wing, London, SE 9RT, UK

    Zoë Urry, Sarah Dimeloe & Catherine M. Hawrylowicz

Authors
  1. Zoë Urry
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  2. Sarah Dimeloe
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  3. Catherine M. Hawrylowicz
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Correspondence to Catherine M. Hawrylowicz .

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Editors and Affiliations

  1. Channing Laboratory, Division of Pulmonary and Critical Care, Harvard Medical School, Brigham and Wome, 181 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Augusto A. Litonjua

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Urry, Z., Dimeloe, S., Hawrylowicz, C.M. (2012). Vitamin D and Regulatory T Cells. In: Litonjua, A. (eds) Vitamin D and the Lung. Respiratory Medicine, vol 3. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-888-7_5

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  • DOI: https://doi.org/10.1007/978-1-61779-888-7_5

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