Abstract
Hepatic encephalopathy (HE) is a severe neuropsychiatric complication occurring both in acute and chronic liver failure. Among patients with cirrhosis, HE is most frequent in patients with advanced liver disease. The restriction of protein intake has long been considered useful in the treatment of such a complication, despite the risk of a worsening in nutritional status. Protein-calorie malnutrition (PCM) is in fact widely recognized to be a frequent finding in cirrhotic patients and to adversely affect the patients’ outcome.
Previous data have shown that protein restriction may increase muscle catabolism and, as a consequence, the release of amino acids, with an elevation in serum ammonia concentration and worsening of HE. The muscle tissue may also play a role in ammonia detoxification, suggesting that protein restriction, by inducing protein malnutrition, may be a contributor of HE instead of an aid in the treatment of this complication. European nutritional guidelines have suggested higher protein requirements in cirrhotic patients and the presence of HE has not been considered a reason to decrease the protein content in the diet. In light of these data, together with the evidence of the safety of a normal protein diet even during acute episodes of HE, much attention has been given to nutritional support in these patients. Multiple meals to shorten the fasting periods have been shown to improve nitrogen economy. When the patient is unable to obtain an adequate nutrient intake, oral supplementation may be used and, if needed, enteral tube feeding or parenteral nutrition is recommended. To improve protein tolerance, vegetable protein-based diets or oral branched-chain amino acid supplementation have been proposed. Branched-chain amino acids have been shown to exert a beneficial effect as they stimulate protein synthesis, secretion of hepatocyte growth factor, and inhibit proteolysis.
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References
Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy. Hepatology. 2009;6:2214–21.
Amodio P, Montagnese S, Gatta A, et al. Characteristics of minimal hepatic encephalopathy. Metab Brain Dis. 2004;19:253–67.
Bajaj JS, Hafeezullah M, Hoffmann RG, et al. Minimal hepatic encephalopathy: a vehicle for accident and traffic violations. Am J Gastroenterol. 2007;102:1903–9.
Bustamante J, Rimola A, Ventura PJ, et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol. 1999;30:890–5.
McPhail MJW, Bajaj JS, Thomas HC, et al. Pathogenesis and diagnosis of hepatic encephalopathy. Expert Rev Gastroenterol Hepatol. 2010;4:365–8.
Wright G, Noiret L, Olde Damink SW, et al. Interorgan ammonia metabolism in liver failure: basis of current and future therapies. Liver Int. 2011;31:163–75.
Mendehall CL, Anderson S, Weesner RE, et al. Protein-calorie malnutrition associated with alcoholic hepatitis. Am J Med. 1994;76:211–22.
Italian Multicentric Cooperative Project on Nutrition in Liver Cirrhosis. Nutritional status in cirrhosis. J Hepatol. 1994;21:317–25.
Caregaro L, Alberino F, Amodio P, et al. Malnutrition in alcoholic and virus-related cirrhosis. Am J Clin Nutr. 1996;63:602–9.
Prijatmoko D, Strauss BJG, Lambert JR, et al. Early detection of protein depletion in alcoholic cirrhosis: role of body composition analysis. Gastroenterology. 1993;105:1839–45.
Alvares-da-Silvia MR, Reverbel da Silveira T. Comparison between handgrip strength, subjective global assessment, and prognostic nutritional index in assessing malnutrition and predicting clinical outcome in cirrhotic outpatients. Nutrition. 2005;21:113–7.
Kalaitzaskis E, Simrén M, Olsson R, et al. Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of life. Scand J Gastroenterol. 2006;41:1464–72.
Gupta A, Dhiman RK, Kumari S, et al. Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy. J Hepatol. 2010;53:849–55.
Aquel BA, Scolapio JS, Dickson RC, et al. Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites. Clin Gastroenterol Hepatol. 2005;3:1095–100.
Merli M, Erikson SL, Hagenfeldt H, et al. Splanchnic and peripheral exchange of FFA in patients with liver cirrhosis. J Hepatol. 1986;3:348–55.
Merli M, Riggio O, Romiti A, et al. Basal energy production rate and substrate use in stable cirrhotic patients. Hepatology. 1990;12:106–12.
Muller MJ, Lautz HU, Plogman B, et al. Energy expenditure and substrate oxidation in patients with cirrhosis: the impact of cause, clinical staging and nutritional status. Hepatology. 1992;15:782–94.
Merli M, Leonetti F, Riggio O, et al. Glucose intolerance and insulin resistance in cirrhosis are normalized after liver transplantation. Hepatology. 1999;30:649–54.
Verboeket-van de Venne WPHG, Westerterp KR, van Hoek B, et al. Energy expenditure and substrate metabolism in patients with cirrhosis of the liver: effects of the pattern of food intake. Gut. 1995;36:110–6.
Zillikens MC, van den Berg JWO, Wattimena JLD, et al. Nocturnal glucose supplementation. The effects on protein metabolism in cirrhotic patients and in healthy controls. J Hepatol. 1993;17:377–83.
Plank LD, Gane EJ, Peng S, et al. Nocturnal nutritional supplementation improves total body protein status of patients with liver cirrhosis: a randomized 12-month trial. Hepatology. 2008;48:557–66.
Merli M, Riggio O, Dally L, et al. Does malnutrition affect survival in cirrhosis? Hepatology. 1996;23:1041–6.
Gunsar F, Raimondo ML, Jones S, et al. Nutritional status and prognosis in cirrhotic patients. Aliment Pharmacol Ther. 2006;24:563–72.
Olde Damink SWM, Jalan R, Redhead DN, et al. Inter organ ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology. 2002;37:1163–70.
Peng S, Lindsay DP, McCall JL, et al. Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr. 2007;85:1257–66.
Campillo B, Richardet JP, Scherman E, et al. Evaluation of nutritional practice in hospitalized cirrhotic patients: results of a prospective study. Nutrition. 2003;19:515–21.
Sörös P, Böttcher J, Weissenborn K, et al. Malnutrition and hypermetabolism are not risk factors for the presence of hepatic encephalopathy: a cross-sectional study. J Gastroenterol Hepatol. 2008;23:606–10.
Kalaitzakis E, Olsson R, Henfridsson P, et al. Malnutrition and diabetes mellitus are related to hepatic encephalopathy in patients with liver cirrhosis. Liver Int. 2007;27:1194–201.
Merli M, Lucidi C, Giannelli V, et al. Cirrhotic patients are at risk for health-care-associated bacterial infections. Clin Gastroenterol Hepatol. 1997;16:43–5.
Merli M, Riggio O. Dietary and nutritional indications in hepatic encephalopathy. Metab Brain Dis. 2009;24:211–21.
Sherlock S, Summerskill WHJ, White LP, et al. Portal-systemic encephalopathy. Neurological complications of liver disease. Lancet. 1954;267:454–7.
Mullen KD, Dasarathy S. Protein restriction in hepatic encephalopathy: necessary evil or illogical dogma? J Hepatol. 2004;41:147–8.
Morgan TR, Moritz TE, Mendenhall CL, et al. Protein consumption and hepatic encephalopathy in alcoholic hepatitis. J Am Coll Nutr. 1995;2:152–8.
Kondrup J, Nielsen K, Juul A. Effect of long-term refeeding on protein metabolism in patients with cirrhosis of the liver. Br J Nutr. 1997;77:197–212.
Plauth M, Merli M, Kondrup J, et al. ESPEN guidelines for nutrition in liver disease and transplantation. Clin Nutr. 1997;16:43–5.
Plauth M, Cabré E, Riggio O, et al. ESPEN guidelines on enteral nutrition: liver disease. Clin Nutr. 2006;25:285–94.
Cordoba J, Lopez-Hellin J, Planas M, et al. Normal protein diet for episodic hepatic encephalopathy results of a randomized study. J Hepatol. 2004;41:38–43.
Gheorghe L, Jacob R, Vadan R, et al. Improvement of hepatic encephalopathy using a modified high-calorie high-protein diet. Rom J Gastroenterol. 2005;3:231–8.
Vaisman N, Katzman H, Carmiel-Haggai M, et al. Breakfast improves cognitive function in cirrhotic patients with cognitive impairment. Am J Clin Nutr. 2010;92:137–40.
Mizock BA. Nutritional support in hepatic encephalopathy. Nutrition. 1999;15:220–8.
Blei AT, Cordoba J. Hepatic encephalopathy. Am J Gastroenterol. 2001;96:1968–75.
Soulsby CT, Morgan MY. Dietary management of hepatic encephalopathy in cirrhotic patients: survey of current practice in United Kingdom. BMJ. 1999;318:1391.
Heyman JK, Whitfield CJ, Brock KE, et al. Dietary protein intakes in patients with hepatic encephalopathy and cirrhosis: current practice in NSW and ACT. Med J Aust. 2006;185:542–3.
Plauth M, Cabré E, Campillo B, et al. ESPEN guidelines on parenteral nutrition: hepatology. Clin Nutr. 2009;28:436–44.
Amodio P, Caregaro L, Pettinò E, et al. Vegetarian diets in hepatic encephalopathy: facts or fantasies? Dig Liver Dis. 2001;33:492–500.
Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition. 2010;26:482–90.
Als Nielsen B, Koretz RL, Kjaergard LL, et al. Branched chain amino acids for hepatic encephalopathy (Cochrane review). Cochrane Database Syst Rev. In The Cochrane Library, Issue 2. Chichester: Wiley; 2004.
Sato S, Watanabe A, Muto Y, et al. Clinical comparison of branched-chain amino acid (L-Leucine, L-Isoleucine, L-Valine) granules and oral nutrition for hepatic insufficiency in patients with decompensated liver cirrhosis (LIV-EN study). Hepatol Res. 2005;31:232–40.
Marchesini G, Bianchi G, Merli M, et al. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial. Gastroenterology. 2003;124:1792–801.
Muto Y, Sato S, Watanabe A, et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol. 2005;3:705–13.
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Merli, M., Giusto, M., Riggio, O. (2012). Nutrition and Hepatic Encephalopathy. In: Mullen, K., Prakash, R. (eds) Hepatic Encephalopathy. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-836-8_16
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DOI: https://doi.org/10.1007/978-1-61779-836-8_16
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