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Asthma and Respiratory Allergic Disease

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Immunotoxicity, Immune Dysfunction, and Chronic Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

The pathogenesis of noncommunicable diseases such as allergy is complex and poorly understood. The causes of chronic allergic diseases including asthma involve to a large extent, immunomodulation of the adaptive and particularly the innate immune systems and are markedly influenced by distinct environmental and genetic interactions. In mammals, the existence of both innate and adaptive immune systems further complicates our ability to understand the mechanisms responsible for allergy and asthma. This chapter discusses the current state of the art in our understanding of allergic immunity and particularly the role of innate immunity as the major conduit linking the host response to the respirable environment. It also provides a conceptual appreciation of the complex interplay between host specific factors and those environmental triggers that challenge the immune system and provoke allergic conditions in susceptible individuals.

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Authors and Affiliations

  1. Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory (NHEERL), US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA

    David M. Lehmann & Marc A. Williams

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  1. David M. Lehmann
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  2. Marc A. Williams
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Correspondence to Marc A. Williams .

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Editors and Affiliations

  1. College of Veterinary Medicine, Dept. Microbiology & Immunology, Cornell University, Ithaca, 14853, New York, USA

    Rodney R. Dietert

  2. National Health and Environmental Effects, Research Laboratories, US Environmental Protection Agency, Research Triangle Park, 27711, USA

    Robert W. Luebke

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The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the agency, nor does the mention of trade names or commercial products constitute endorsement or recommendation for use. Additionally, the views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or of the U.S. Environmental Protection Agency.

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Lehmann, D.M., Williams, M.A. (2012). Asthma and Respiratory Allergic Disease. In: Dietert, R., Luebke, R. (eds) Immunotoxicity, Immune Dysfunction, and Chronic Disease. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-812-2_3

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