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Reducing the Prevalence of Immune-Based Chronic Disease

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Immunotoxicity, Immune Dysfunction, and Chronic Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

As described in prior chapters of this book, chronic diseases connected to immune and inflammatory dysfunction are often categorized based on the affected tissues and, as a result, can be overlooked as being immune-mediated diseases. These diseases are numerous in nature, costly to individuals, families and nations, and pervasive. They represent an emerging global health threat where effective strategies capable of reducing disease prevalence have been slow to emerge. This concluding chapter includes information on four additional immune/inflammatory-based diseases or conditions: psoriasis, autoimmune thyroiditis, frailty, and an isolation-withdrawal state. It also provides an overview of plans for reducing the risk of immune-based chronic disease and emphasizes the importance of acting early in life and using safety data that are directly relevant to priority chronic diseases. The risk-reduction strategy combines four key components: widespread outcome-based safety testing that precedes human exposure, whole-life-considered therapeutic interventions, strategic research, and effective public health policies.

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Acknowledgments

The authors thank Janice Dietert for her editorial assistance and Drs. Marsha Ward and Jared Brown for their thoughtful review of the chapter.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, North Tower Road, Ithaca, NY, 14853, USA

    Rodney R. Dietert

  2. Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA

    Jamie C. DeWitt

  3. Cardiopulmonary and Immunotoxicology Branch, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA

    Robert W. Luebke

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Correspondence to Rodney R. Dietert .

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Editors and Affiliations

  1. College of Veterinary Medicine, Dept. Microbiology & Immunology, Cornell University, Ithaca, 14853, New York, USA

    Rodney R. Dietert

  2. National Health and Environmental Effects, Research Laboratories, US Environmental Protection Agency, Research Triangle Park, 27711, USA

    Robert W. Luebke

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This report has been reviewed by the Environmental Protection Agency’s Office of Research and Development, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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Dietert, R.R., DeWitt, J.C., Luebke, R.W. (2012). Reducing the Prevalence of Immune-Based Chronic Disease. In: Dietert, R., Luebke, R. (eds) Immunotoxicity, Immune Dysfunction, and Chronic Disease. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-812-2_17

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