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Atherosclerosis and Inflammatory Heart Disease

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Immunotoxicity, Immune Dysfunction, and Chronic Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

Cardiovascular disease (CVD) is the leading cause of mortality ­worldwide, with atherosclerosis accounting for most deaths. Inflammation is a key component in the pathogenesis of CVDs such as atherosclerosis, stroke, myocarditis, dilated cardiomyopathy, and heart failure. A number of recent clinical and animal model findings suggest that the pathogenesis of autoimmune and CVDs may be linked. Many potentially modifiable risk factors like diet, tobacco smoking, and infections have been associated with increased cardiovascular risk for both atherosclerosis and several autoimmune diseases including myocarditis, systemic lupus erythematosus, and rheumatoid arthritis. Although many autoimmune diseases are more prevalent in women, the risk for developing CVD remains elevated in men. Future studies should examine sex differences in CVD biomarkers following infection and/or toxicant exposure.

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Acknowledgments

This work was supported by National Institutes of Health Grant HL087033.

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Authors and Affiliations

  1. Department of Environmental Health Sciences, Division of Molecular and Translational Toxicology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Room E7628, Baltimore, MD, 21205, USA

    DeLisa Fairweather

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  1. DeLisa Fairweather
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Correspondence to DeLisa Fairweather .

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Editors and Affiliations

  1. College of Veterinary Medicine, Dept. Microbiology & Immunology, Cornell University, Ithaca, 14853, New York, USA

    Rodney R. Dietert

  2. National Health and Environmental Effects, Research Laboratories, US Environmental Protection Agency, Research Triangle Park, 27711, USA

    Robert W. Luebke

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Fairweather, D. (2012). Atherosclerosis and Inflammatory Heart Disease. In: Dietert, R., Luebke, R. (eds) Immunotoxicity, Immune Dysfunction, and Chronic Disease. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-812-2_11

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