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Cytoskeleton and Human Disease pp 241–257Cite as

Posttranslational Modifications of Tubulin

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Abstract

Recent studies have highlighted the potential importance of posttranslational modifications of tubulin in dictating response to antitumor drugs and disease progression. These modifications include glutamylation, glycylation, phosphorylation, acetylation, and tyrosination. Some of the tubulin-modifying enzymes have been identified but the functional consequences of the posttranslational modifications remain largely unknown. In this chapter, we review the posttranslational modifications of tubulin and current knowledge of the role these alterations may play in human disease.

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  1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA

    Suzan K. Chao, Chia-Ping H. Yang & Susan Band Horwitz

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  1. Suzan K. Chao
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  2. Chia-Ping H. Yang
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Correspondence to Susan Band Horwitz .

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  1. Australia for Medical Research, Iron Metabolism Program, Children's Cancer Institute, Randwick, New South Wales, Australia

    Maria Kavallaris

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Chao, S.K., Yang, CP.H., Horwitz, S. (2012). Posttranslational Modifications of Tubulin. In: Kavallaris, M. (eds) Cytoskeleton and Human Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-788-0_13

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