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Clinical Consequences of Oxidative Stress in Male Infertility

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Studies on Men's Health and Fertility

Abstract

Male infertility affects 40% of infertile couples in the USA and may be attributed to conditions such as varicocele, leukocytospermia, infection, and idiopathic infertility. Such conditions may be associated with elevated levels of reactive oxygen species (ROS), decreased antioxidants, and oxidative stress (OS). OS can lead to male infertility in both an in vitro and in vivo setting. The negative effects of ROS on male fertility present as sperm DNA damage, decreasing motility, apoptosis, and lipid peroxidation. ROS and antioxidant levels can be measured and quantified in order to detect OS in semen samples. Both oral antioxidant therapy and culture media supplementation have proven to be effective in reducing OS. Future research is still needed in order to better understand the mechanisms involved in oxidative damage in the context of male infertility and to improve the treatments available for patients with OS-mediated male factor infertility.

This research was conducted at the Cleveland Clinic’s Center for Reproductive Medicine, Cleveland, OH.

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Authors and Affiliations

  1. Andrology Laboratory and Reproductive Tissue Bank, The Toronto Institute for Reproductive Medicine, 56 Aberfoyle Crescent, Toronto, ON, Canada, M8X2W4

    Tamer M. Said MD, PhD, HCLD (ABB)

  2. Center for Reproductive Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Sheila R. Gokul

  3. Center for Reproductive Medicine, Cleveland Clinic, Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Ashok Agarwal PhD

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  1. Tamer M. Said MD, PhD, HCLD (ABB)
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  2. Sheila R. Gokul
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  3. Ashok Agarwal PhD
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Correspondence to Ashok Agarwal PhD .

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Editors and Affiliations

  1. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

  2. Faculty of Science and IT, Department of Biological Sciences, University of Newcastle, University Drive 1, Callaghan, 2308, New South Wales, Australia

    R. John Aitken

  3. , Department of Male Infertility, Centro Androgen, C/FERNANDO MACIAS 8, 1ºC, La Coruña, 15004, La Coruña, Spain

    Juan G. Alvarez

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Said, T.M., Gokul, S.R., Agarwal, A. (2012). Clinical Consequences of Oxidative Stress in Male Infertility. In: Agarwal, A., Aitken, R., Alvarez, J. (eds) Studies on Men's Health and Fertility. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-776-7_24

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