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Oxidative Stress and the Use of Antioxidants for Idiopathic OATs

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Studies on Men's Health and Fertility

Abstract

Aim: To examine the effects of ROS and OS on male fertility and to evaluate the use of antioxidants as a means of treatment to improve fertilization rates in subfertile males suffering from idiopathic oligoasthenoteratozoospermia (iOAT). Methods: Review of PubMed database. Results: Current research notes ROS-associated male factor infertility to be the most common potential etiology of impaired sperm quality. The various effects of these oxidants may be neutralized by antioxidants. Although antioxidant therapy has shown to potentially treat iOAT by improving semen parameters, its success remains limited. Our review calls for a deeper look and understanding of the type(s), dosage, and duration of antioxidant treatment used in order to apply its use in a clinical setting.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Cleveland Clinic, Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Ashok Agarwal PhD

  2. Center for Reproductive Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Anthony H. Kashou BS

  3. Medical Center, OBGYN, Mount Sinai School of Medicine, New York, NY, USA

    Lucky H. Sekhon MD, BSc

Authors
  1. Ashok Agarwal PhD
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  2. Anthony H. Kashou BS
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  3. Lucky H. Sekhon MD, BSc
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Corresponding author

Correspondence to Ashok Agarwal PhD .

Editor information

Editors and Affiliations

  1. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

  2. Faculty of Science and IT, Department of Biological Sciences, University of Newcastle, University Drive 1, Callaghan, 2308, New South Wales, Australia

    R. John Aitken

  3. , Department of Male Infertility, Centro Androgen, C/FERNANDO MACIAS 8, 1ºC, La Coruña, 15004, La Coruña, Spain

    Juan G. Alvarez

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Agarwal, A., Kashou, A.H., Sekhon, L.H. (2012). Oxidative Stress and the Use of Antioxidants for Idiopathic OATs. In: Agarwal, A., Aitken, R., Alvarez, J. (eds) Studies on Men's Health and Fertility. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-776-7_22

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