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Effect of Oxidative Stress on ART Outcome

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Studies on Men's Health and Fertility

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Abstract

Oxidative stress is a condition that causes cellular damage including destruction of all cellular components including lipids, proteins, nucleic acids, and sugars. It affects negatively the quality of oocytes, sperm oocyte interaction, implantation, and early embryo development which influence the success of pregnancy. Many events related to infertility may occur due to OS in the female reproductive tract, such as endometriosis, hydrosalpinx, polycystic ovarian disease, unexplained infertility, and recurrent pregnancy loss. Oxidative stress may cause retardation in embryo development and growth due to cell-membrane damage, DNA damage, and apoptosis. Poor quality of spermatozoa due to oxidative stress has been correlated with poor fertilization rates, impaired embryo development, and increased rates of pregnancy loss. There are many strategies that overcome OS in assisted reproductive techniques like ensuring in vitro culture under low oxygen tension, antioxidant culture media supplementation, control of sperm reactive oxygen species production, and reducing sperm-oocyte coincubation time.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Saarland, Homburg, Saarland, Germany

    Mohamad Eid Hammadeh DVM, BSc, PhD & Constanze Fischer-Hammadeh MD

  2. Department of Pharmacology and Bioscience, Petra University, Amman, Jordan

    Mohammed Hamad PhD

  3. Department of Obstetrics and Gynecology, Al Azhar University, Assiut, Egypt

    Khaled Refaat MD

  4. Andrology Laboratory and Reproductive Tissue Bank, The Toronto Institute for Reproductive Medicine, 56 Aberfoyle Crescent, Toronto, ON, Canada, M8X2W4

    Tamer M. Said MD, PhD, HCLD (ABB)

Authors
  1. Mohamad Eid Hammadeh DVM, BSc, PhD
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  2. Mohammed Hamad PhD
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  3. Khaled Refaat MD
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  4. Tamer M. Said MD, PhD, HCLD (ABB)
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  5. Constanze Fischer-Hammadeh MD
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Correspondence to Mohamad Eid Hammadeh DVM, BSc, PhD .

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Editors and Affiliations

  1. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

  2. Faculty of Science and IT, Department of Biological Sciences, University of Newcastle, University Drive 1, Callaghan, 2308, New South Wales, Australia

    R. John Aitken

  3. , Department of Male Infertility, Centro Androgen, C/FERNANDO MACIAS 8, 1ºC, La Coruña, 15004, La Coruña, Spain

    Juan G. Alvarez

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Hammadeh, M.E., Hamad, M., Refaat, K., Said, T.M., Fischer-Hammadeh, C. (2012). Effect of Oxidative Stress on ART Outcome. In: Agarwal, A., Aitken, R., Alvarez, J. (eds) Studies on Men's Health and Fertility. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-776-7_21

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