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Recreational Drugs and ROS Production in Mammalian Spermatozoa

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Studies on Men's Health and Fertility

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Abstract

Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and antioxidant capacity of the cell. Oxidative stress appears to be the major cause of DNA damage in the male germ line. Furthermore, many studies have indicated a significant correlation between DNA damage and high levels of ROS in infertile patients. Male reproductive health is already under threat from a range of environmental factors including endocrine disruptors, toxic pollutants, ionizing and lifestyle factors such as sexually transmitted infections, alcoholism, smoking, and anabolic steroid use. Further hazards such as fast food, recreational drugs, and stress levels may also impair male fertility. Recreational drugs such as alcohol, barbiturates, amphetamines, THC, PCP, cocaine, and heroin, but also includes caffeine in coffee and cola beverages, and environmental factors may increase ROS production, leading to DNA damage and further male infertility.

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Authors and Affiliations

  1. Department of Urology, University of Caxias do Sul, Pinheiro Machado 2569, sl 23/24, Caxias do Sul, RS, 95020172, Brazil

    Fábio Firmbach Pasqualotto MD, PhD

  2. Department of Gynecology, University of Caxias do Sul, Caxias do Sul, RS, Brazil

    Eleonora Bedin Pasqualotto MD, PhD

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  1. Fábio Firmbach Pasqualotto MD, PhD
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  2. Eleonora Bedin Pasqualotto MD, PhD
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Correspondence to Fábio Firmbach Pasqualotto MD, PhD .

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Editors and Affiliations

  1. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

  2. Faculty of Science and IT, Department of Biological Sciences, University of Newcastle, University Drive 1, Callaghan, 2308, New South Wales, Australia

    R. John Aitken

  3. , Department of Male Infertility, Centro Androgen, C/FERNANDO MACIAS 8, 1ºC, La Coruña, 15004, La Coruña, Spain

    Juan G. Alvarez

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Pasqualotto, F.F., Pasqualotto, E.B. (2012). Recreational Drugs and ROS Production in Mammalian Spermatozoa. In: Agarwal, A., Aitken, R., Alvarez, J. (eds) Studies on Men's Health and Fertility. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-776-7_19

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