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Regenerative Therapy Using Blood-Derived Stem Cells pp 125–139Cite as

Regenerative Potential of Blood Stem Cell Products Used in Hematopoietic Stem Cell Transplantation

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In this chapter, we address the role of nonhematopoietic progenitors with regenerative potential that are present in blood stem cell grafts used in hematopoietic transplantation. In particular, we discuss the potential role of nonhematopoietic progenitors in reducing transplant-associated tissue toxicity. We discuss specific cell types including endothelial progenitors and mesenchymal stromal cells that may be associated with tissue repair, and we discuss some potential strategies for augmenting the regenerative capacity of blood stem cell products which could have more widespread applicability to a broad range of acute tissue injuries.

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Authors and Affiliations

  1. Regenerative Medicine Program, Ottawa Hospital Research Institute, Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa, ON, Canada

    Laura Labonté & David S. Allan

  2. Departments of Medicine and Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada

    Laura Labonté & David S. Allan

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  1. Laura Labonté
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  2. David S. Allan
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Correspondence to David S. Allan .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Parkdale Ave 725, Ottawa, K1Y4E9, Ontario, Canada

    David S. Allan

  2. , Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstraße 24, Graz, A - 8010, Austria

    Dirk Strunk

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Labonté, L., Allan, D.S. (2012). Regenerative Potential of Blood Stem Cell Products Used in Hematopoietic Stem Cell Transplantation. In: Allan, D., Strunk, D. (eds) Regenerative Therapy Using Blood-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-471-1_10

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