Abstract
Among gestational trophoblastic disorders, hydatidiform moles are the most common in the daily practice of gynecological pathology and frequently diagnostically challenging. While histological diagnosis of well-developed complete hydatidiform mole is generally reliable (see Chaps. 5 and 6), an early evacuated complete mole often presents with minimal histological abnormalities and is easily mistaken as a hydropic abortus or a normal pregnancy by both clinicians and pathologists (Adv Anat Pathol 12(3):116-25, 2005). Partial hydatidiform moles have been proven the most diagnostically difficult. At present time and even with available ancillary studies, pathologists cannot reliably classify a partial mole from its many mimics with both under- and over-diagnosis in a significant percentage of the cases.
This chapter is an update based on Expert Rev. Mol. Diag. 10(8), 1023–1034 (2010) with permission from Expert Reviews Ltd.
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Hui, P. (2012). Molecular Diagnosis of Gestational Trophoblastic Disease. In: Hui, P. (eds) Gestational Trophoblastic Disease. Current Clinical Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-61779-394-3_11
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