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Cell Migration

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Adhesive Interactions in Normal and Transformed Cells

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Abstract

The fibroblastic cell migration machinery involves such factors as cytoskeleton-regulated formation of pseudopodia, cell morphological polarization, dynamic regulation of focal adhesions during cell migration, integrin- and growth factor receptor-mediated signaling. The inhibition of directional movement of one cell across the surface of another cell caused by intercellular collisions (the phenomenon called “contact inhibition of cell migration”) and also biochemical, physical, and topographic characteristics of the extracellular matrix are also pivotal factors, which determine and control cell migration activity and the direction of migration. Oncogenic transformation causes various abnormalities of cell migration machinery. These alterations apply to adhesion and signaling functions of focal contacts in transformed cells, and also to the sensitivity of the cells to soluble growth factors.

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  1. Research Center of the Russian Academy of Medical Sciences, Moscow, Russia

    Yury A. Rovensky M.D., Ph.D., D.Sci (Former Leading Researcher at Cancer)

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Rovensky, Y.A. (2011). Cell Migration. In: Adhesive Interactions in Normal and Transformed Cells. Humana Press. https://doi.org/10.1007/978-1-61779-304-2_6

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