Abstract
The extracellular matrix is the ordered macromolecular network, on the surface of which and inside the tissue cells are attached to it and to each other, migrate, proliferate or survive. The matrix is composed of protein–carbohydrate complexes, which, in particular, include the glycoproteins carrying out mainly structural or mainly adhesive functions. The extracellular matrix is not only a mechanical framework but also a regulator of cell behavior. The matrix proteins are bound with the specific cell surface receptors resulting in the cell–matrix adhesion, which exerts effect on cell shapes, migration, proliferation, cell survival, and metabolism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Heinegård D (2009) Proteoglycans and more- from molecules to biology. Int J Exp Pathol 90(6):575–586
Kirn-Safran C, Farach-Carson MC, Carson DD (2009) Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans. Cell Mol Life Sci 66(21):3421–3434. doi:10.1007/s00018-009-0096-1 DOI:dx.doi.org
Schaefer L, Schaefer RM (2010) Proteoglycans: from structural compounds to signaling Âmolecules. Cell Tissue Res 339(1):237–246. doi:10.1007/s00441-009-0821-y DOI:dx.doi.org
Mythreye K, Blobe GC (2009) Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion. Cell Signal 21(11):1548–1558. doi:10.1016/j.cellsig.2009.05.001 DOI:dx.doi.org
Xian X, Gopal S, Couchman JR (2010) Syndecans as receptors and organizers of the extracellular matrix. Cell Tissue Res 339(1):31–46. doi:10.1007/s00441-009-0829-3 DOI:dx.doi.org
Bass MD, Morgan MR, Humphries MJ (2009) Syndecans shed their reputation as inert molecules. Sci Signal 2(64): pe18. doi:10.1126/scisignal.264pe18 DOI:dx.doi.org
Lambaerts K, Wilcox-Adelman SA, Zimmermann P (2009) The signaling mechanisms of syndecan heparan sulfate proteoglycans. Curr Opin Cell Biol 21(5):662–669. doi:10.1016/j.ceb.2009.05.002 DOI:dx.doi.org
Schmidt S, Friedl P (2010) Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res 339(1):83–92. doi:10.1007/s00441-009-0892-9 DOI:dx.doi.org
Streuli CH, Akhtar N (2009) Signal co-operation between integrins and other receptor systems. Biochem J 418(3):491–506. doi:10.1042/BJ20081948 DOI:dx.doi.org
Gordon MK, Hahn RA (2010) Collagens. Cell Tissue Res 339(1):247–257. doi:10.1007/s00441-009-0844-4 DOI:dx.doi.org
Shoulders MD, Raines RT (2009) Collagen structure and stability. Annu Rev Biochem 78:929–958. doi:10.1146/annurev.biochem.77.032207.120833 DOI:dx.doi.org
Ramirez F, Sakai LY (2010) Biogenesis and function of fibrillin assemblies. Cell Tissue Res 339(1):71–82. doi:10.1007/s00441-009-0822-x DOI:dx.doi.org
White ES, Baralle FE, Muro AF (2008) New insights into form and function of fibronectin splice variants. J Pathol 216(1):1–14. doi:10.1002/path.2388 DOI:dx.doi.org
Leiss M, Beckmann K, Girós A, Costell M, Fässler R (2008) The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol 20(5):502–507. doi:10.1016/j.ceb.2008.06.001 DOI:dx.doi.org
Brellier F, Tucker RP, Chiquet-Ehrismann R (2009) Tenascins and their implications in diseases and tissue mechanics. Scand J Med Sci Sports 19(4):511–519. doi:10.1111/j.1600-0838.2009.00916.x DOI:dx.doi.org
Tucker RP, Chiquet-Ehrismann R (2009) The regulation of tenascin expression by tissue microenvironments. Biochim Biophys Acta 1793(5):888–892. doi:10.1016/j.bbamcr.2008.12.012 DOI:dx.doi.org
de Vega S, Iwamoto T, Yamada Y (2009) Fibulins: multiple roles in matrix structures and tissue functions. Cell Mol Life Sci 66(11–12):1890–1902. doi:10.1007/s00018-009-8632-6 DOI:dx.doi.org
Hynes RO (2009) The extracellular matrix: not just pretty fibrils. Science 326 (5957):1216–1219. doi:10.1126/science.1176009 DOI:dx.doi.org
Tsang KY, Cheung MC, Chan D, Cheah KS (2010) The developmental roles of the extracellular matrix: beyond structure to regulation. Cell Tissue Res 339(1):93–110. doi:10.1007/s00441-009-0893-8 DOI:dx.doi.org
Rozario T, DeSimone DW (2010) The extracellular matrix in development and morphogenesis: a dynamic view. Dev Biol 341(1):126–140. doi:10.1016/j.ydbio.2009.10.026 DOI:dx.doi.org
Sofat N (2009) Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J Exp Pathol 90(5):463–479. doi:10.1111/j.1365-2613.2009.00676.x DOI:dx.doi.org
Järveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R (2009) Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev 61(2):198–223. doi:10.1124/pr.109.001289 DOI:dx.doi.org
Salerno FG, Barbaro MP, Toungoussova O, Carpagnano E, Guido P, Spanevello A (2009) The extracellular matrix of the lung and airway responsiveness in asthma. Monaldi Arch Chest Dis 71(1):27–30
Yurchenco PD, Patton BL (2009) Developmental and pathogenic mechanisms of basement membrane assembly. Curr Pharm Des 15(12):1277–1294. doi:10.2174/138161209787846766 DOI:dx.doi.org
Loeser RF (2009) Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage 17(8):971–979. doi:10.1016/j.joca.2009.03.002 DOI:dx.doi.org
Bateman JF, Boot-Handford RP, Lamandé SR (2009) Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations. Nat Rev Genet 10(3):173–183. doi:10.1038/nrg2520 DOI:dx.doi.org
Malfait F, De Paepe A (2009) Bleeding in the heritable connective tissue disorders: mechanisms, diagnosis and treatment. Blood Rev 23(5):191–197. doi:10.1016/j.blre.2009.06.001 DOI:dx.doi.org
Carter EM, Raggio CL (2009) Genetic and orthopedic aspects of collagen disorders. Curr Opin Pediatr 21(1):46–54. doi:10.1097/MOP.0b013e32832185c5 DOI:dx.doi.org
Maraldi NM, Sabatelli P, Columbaro M, Zamparelli A, Manzoli FA, Bernardi P, Bonaldo P, Merlini L (2009) Collagen VI myopathies: from the animal model to the clinical trial. Adv Enzyme Regul 49(1):197–211. doi:10.1016/j.advenzreg.2008.12.009 DOI:dx.doi.org
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Rovensky, Y.A. (2011). The Extracellular Matrix. In: Adhesive Interactions in Normal and Transformed Cells. Humana Press. https://doi.org/10.1007/978-1-61779-304-2_2
Download citation
DOI: https://doi.org/10.1007/978-1-61779-304-2_2
Published:
Publisher Name: Humana Press
Print ISBN: 978-1-61779-303-5
Online ISBN: 978-1-61779-304-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)