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Pancreatic Plasticity and Reprogramming: Novel Directions Towards Disease Therapy

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Nuclear Reprogramming and Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Generating new β-cells de novo, or regenerating them in vivo, as a cellular therapy, is becoming more tenable as a realistic goal for treatment of the devastating disease of diabetes. One suitable approach towards generating β-cells is to use ­combinations of instructive and permissive cues to induce the transdifferentiation of terminally differentiated cell types into functional β-cells, which is called ­reprogramming. Interesting cellular transformations reported recently during development and regeneration suggest that a wide variety of differentiated cell types in the human body may be amenable to such reprogramming. In this chapter, we highlight findings and potential approaches using cell types that are developmentally related to β-cells, and the known molecular players that may be used to control β-cell-directed transdifferentiation. Further investigation with genetic model systems, coupled with the translation to clinically sound reprogramming methods, could lead to efficient reprogramming of specific cell types, with a massive impact on human health.

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Authors and Affiliations

  1. Vanderbilt University Medical Center, Nashville, TN, USA

    Spencer Willet

  2. Vanderbilt University Medical Center, 465 21st Avenue South, 3144 MRBIII, Nashville, TN, 37232, USA

    Chris Wright

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Editors and Affiliations

  1. Leeds Institute of Genetics,, Health & Therapeutics, University of Leeds, Leeds, LS2 9JT, United Kingdom

    Justin Ainscough

  2. Inst. Frontier Medical Sciences, Kyoto University, Kawahara-cho 53, Kyoto, 606-8507, Japan

    Shinya Yamanaka

  3. Inst. Frontier Medical Sciences, Kyoto University, Kawahara-cho 53, Kyoto, 606-8507, Japan

    Takashi Tada

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Willet, S., Wright, C. (2011). Pancreatic Plasticity and Reprogramming: Novel Directions Towards Disease Therapy. In: Ainscough, J., Yamanaka, S., Tada, T. (eds) Nuclear Reprogramming and Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-225-0_15

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