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Regenerating the Heart pp 131–147Cite as

Evidence for the Existence of Resident Cardiac Stem Cells

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The heart has traditionally been considered a terminally differentiated organ. In the past 10 years, though, this paradigm has been challenged and proved questionable, starting from the evidence of cycling myocytes in the adult heart, both in physiological and in pathological conditions. In addition, the discovery and isolation of cells from the adult heart with progenitor-like and stem-like features has started a new field of research. These topics are reviewed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Molecular Medicine and Pathology, Cenci-Bolognetti Foundation, University “Sapienza” of Rome, Rome, Italy

    Alessandro Giacomello

Authors
  1. Isotta Chimenti
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  2. Roberto Gaetani
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  3. Lucio Barile
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  4. Elvira Forte
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  5. Vittoria Ionta
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  6. Francesco Angelini
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  7. Elisa Messina
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  8. Alessandro Giacomello
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Corresponding author

Correspondence to Alessandro Giacomello .

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Editors and Affiliations

  1. Health Sciences Center, Dept. Physiology & Biophysics, Stony Brook University, Stony Brook, 11794-8661, New York, USA

    Ira S. Cohen

  2. Worcester Polytechnic Institute, Institute Rd. 100, Worcester, 01609-2280, Massachusetts, USA

    Glenn R. Gaudette

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Chimenti, I. et al. (2011). Evidence for the Existence of Resident Cardiac Stem Cells. In: Cohen, I., Gaudette, G. (eds) Regenerating the Heart. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-021-8_9

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