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Homing, Survival, and Paracrine Effects of Human Mesenchymal Stem Cells

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Regenerating the Heart

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

In this chapter we describe a snapshot of the ever-changing landscape for the use of mesenchymal stem cells (MSCs) as a therapeutic agent. To be used for cell therapy, they must reach their target and have a therapeutic effect. Determinants of MSC homing are considered in the first part of the chapter, with special emphasis on the dynamic nature of these cells reflected in changes of their chemokine receptor profile with the associated implication of these changes for homing to sites of injury. In the second part of the chapter we consider therapeutic effects of MSCs at their target sites mediated by the paracrine factors they produce.

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  1. Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA

    Sergey Doronin

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  1. Health Sciences Center, Dept. Physiology & Biophysics, Stony Brook University, Stony Brook, 11794-8661, New York, USA

    Ira S. Cohen

  2. Worcester Polytechnic Institute, Institute Rd. 100, Worcester, 01609-2280, Massachusetts, USA

    Glenn R. Gaudette

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Doronin, S. (2011). Homing, Survival, and Paracrine Effects of Human Mesenchymal Stem Cells. In: Cohen, I., Gaudette, G. (eds) Regenerating the Heart. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-021-8_7

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