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Regenerating the Heart pp 263–280Cite as

Induced Pluripotent Cells for Myocardial Infarction Repair

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Managing the rapidly expanding scope of chronic degenerative heart ­disease is a major clinical challenge. Owing to progressive cellular destruction and loss of functional tissues, chronic degenerative diseases are responsible for many of the disabilities suffered throughout lifespan. This creates an ever-growing need for new therapies capable of repairing the underlying pathophysiologic changes and restoring native cellular architecture. The emergence of regenerative medicine expands the therapeutic armamentarium, establishing new paradigms to address disease management unmet by traditional strategies. Stem-cell-based regenerative medicine drives the evolution of medical sciences from palliation, which mitigates symptoms, to curative therapy aimed at treating the root cause of degenerative disease and thus promoting long-term wellness.

With the optimization of acute hospital care, more individuals are surviving life-threatening myocardial infarction and deferring the burden of ischemic heart disease as they accumulate incremental insults leading to progressive heart failure. The incidence of long-term complications of inadequate cardiac performance is increasingly recognized as an unmet need within health care systems. An attractive alternative to address this expanding challenge has been documented with stem cell therapeutics. Specialized stem cell populations demonstrate a unique aptitude to differentiate into cardiac progenitors, and form new tissue. Cell-based strategies that promote, augment, and reestablish repair are at the core of translating the science of stem cell biology into the practice of cardiovascular regenerative medicine. Here, the latest evolution of stem-cell-based therapy, with emphasis on a bioengineered pluripotent stem cell platform, is outlined from discovery science to potential clinical use in the setting of ischemic heart disease.

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Authors and Affiliations

  1. Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology and Experimental Therapeutics and Medical Genetics, Mayo Clinic, Rochester, MN, 55905, USA

    Andre Terzic

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  1. Timothy J. Nelson
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  2. Andre Terzic
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Correspondence to Andre Terzic .

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  1. Health Sciences Center, Dept. Physiology & Biophysics, Stony Brook University, Stony Brook, 11794-8661, New York, USA

    Ira S. Cohen

  2. Worcester Polytechnic Institute, Institute Rd. 100, Worcester, 01609-2280, Massachusetts, USA

    Glenn R. Gaudette

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Nelson, T.J., Terzic, A. (2011). Induced Pluripotent Cells for Myocardial Infarction Repair. In: Cohen, I., Gaudette, G. (eds) Regenerating the Heart. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-021-8_15

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