Abstract
In the past, intraoperative radiotherapy (IORT) was reserved for centres equipped with dedicated linear accelerators in specially shielded operating rooms (ORs) or, with great inconvenience, in a conventional radiotherapy room using transport from the operating room. By using mobile/portable IORT devices with low-kV X-rays that have a steep dose gradient, the possibility of treating patients with IORT is no longer restricted to the availability of special operating rooms, but can be done in regular, unshielded ORs. Another disadvantage of IORT devices in the past was that the anesthetised patient had to be moved for the treatment from the OR table to the accelerator.
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Notes
- 1.
Cytyc Corporation, Marlborough, MA 01752.
- 2.
Nucletron, Columbia, MD 21046.
- 3.
IEC 60601-1-1 International Electrotechnical Commission.
- 4.
Carl Zeiss Surgical, 73447 Oberkochen, Germany.
References
Vaidya JS, Baum M, Tobias JS, et al. Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Ann Oncol. 2001;12:1075–80.
Curry WT, Cosgrove GR, Hochberg FH, et al. Stereotactic interstitial radiosurgery for cerebral metastases. J Neurosurg. 2005;103:630–5.
Algur E, Mahadevan A, Deibel C, et al. Interstitial photon radiosurgery system for recurrent and locally advanced rectal cancer: a retrospective review for 24 patients. ASCO-GI 2005; abstract 208.
Kraus-Tiefenbacher U, Bauer L, Kehrer T, et al. Intraoperative radiotherapy (IORT) as a boost in patients with early-stage breast cancer – acute toxicity. Onkologie. 2006;29:77–82.
Kraus-Tiefenbacher U, Bauer L, Scheda A, et al. Long-term toxicity of an intraoperative radiotherapy boost using low energy x-rays during breast conserving surgery. Int J Radiat Oncol Biol Phys. 2006;66(2):377–81.
Joseph DJ, Bydder S, Jackson LR, et al. Prospective trial of intraoperative radiation treatment for breast cancer. ANZ J Surg. 2004;74:1043–8.
Vaidya JS, Baum M, Tobias JS, et al. Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost. Int J Radiat Oncol Biol Phys. 2006;66:1335–8.
Wenz F, Welzel G, Keller A, et al. Early initiation of external beam radiotherapy (EBRT) increases the risk of long term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer. Breast. 2008;17:617–22.
Bartelink H, Horiot HC, Poortmans P, et al. Recurrence rate after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001;345:1378–87.
Benda RK, Yasuda G, Sethi A, et al. Breast boost: are we missing the target. Cancer. 2003;97:905–9.
Poortmans P, Bartelink H, Horiot JC, et al. The influence of the boost technique on local control in breast conserving treatment in the EORTC ‘boost versus no boost’ randomised trial. Radiother Oncol. 2004;72:25–33.
Bartelink H, Horiot JC, Poortmans P, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10 year results of the randomized boost versus no-boost EORTC 22881-10882 trial. J Clin Oncol. 2007;25:3259–65.
Holland R, Veiling SH, Mravunac M, et al. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 1985;56:979–90.
Morrow M, White J, Moughan J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol. 2001;19:2254–62.
Belletti B, Vaidya JS, D‘Andrea S, et al. Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res. 2008;14:1325–32.
Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–41.
Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–32.
Kurtz JM, Amalric R, Brandone H, et al. Local recurrence after breast conserving surgery and radiotherapy. Frequency, time course, and prognosis. Cancer. 1989;63:1912–7.
Smith TE, Lee D, Turner BC, et al. True recurrence vs. new primary ipsilateral breast tumour relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys. 2000;48:1281–9.
Clark RM, McCulloch PB, Levine MN, et al. Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer. J Natl Cancer Inst. 1992;84:683–9.
Liljegren G, Holmberg L, Adami HO, et al. Sector resection with or without postoperative radiotherapy for stage I breast cancer: five-year results of a randomized trial. Uppsala-Orebro Breast Cancer Study Group. J Natl Cancer Inst. 1994;86:717–22.
Forquet A, Campana F, Zafrani B, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989;17:719–25.
Fowble B, Solin LJ, Schultz DJ, et al. Breast recurrence following conservative surgery and radiotherapy: patterns of failure, prognosis, and pathologic findings from mastectomy specimens with implication for treatment. Int J Radiat Oncol Biol Phys. 1990;19:833–942.
Vaidya JS, Tobias J, Baum M, et al. Protocol 00PRT/47 targeted intraoperative radiotherapy (TARGIT) for breast cancer. The Lancet Oncology Website 12/1999.
Beatty J, Biggs PJ, Gall K, Okunieff P, Pardo FS, Harte KJ, et al. A new miniature x-ray source for the interstitial radiosurgery: dosimetry. Med Phys. 1996;23:53–62.
Yanch JC, Harte KJ. Monte Carlo simulation of a miniature radiosurgery x-ray tube using the ITS 3.0 coupled electron-photon transport code. Med Phys. 1996;23:1551–8.
Rivard MJ, Davis SD, DeWerd LA, et al. Calculated and measured brachytherapy dosimetry parameters in water for the Xoft Axxent x-ray source: an electronic brachytherapy source. Med Phys. 2006;33:4020–32.
Sliski A, Soares C, Mitch M. A fibre optic scintillator dosemeter for absorbed dose measurements of low-energy x-ray emitting brachytherapy sources. Radiat Prot Dosimetry. 2006;120:24–7.
Hiatt J, Cardarelli G, Hepel J, et al. A commissioning procedure for breast intracavitary electronic brachytherapy systems. J Appl Clin Med Phys. 2008;9:58–68.
Dickler A, Ivanov O, Francescatti D. Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing Xoft axxent electronic brachytherapy. World J Surg Oncol. 2009;7:1–6.
Liu D, Poon E, Bazalova M, et al. Spectroscopic characterization of a novel electronic brachytherapy system. Phys Med Biol. 2008;53:61–75.
Smitt M, Kirby R. Dosimetry of 50 kV electronic brachytherapy for accelerated partial breast irradiation. Brachytherapy. 2007;6:207–11.
Bodner WR, Hilaris BS, Alagheband M, et al. Use of low-energy X-rays in the treatment of superficial nonmelanomatous skin cancers. Cancer Invest. 2003;21(3):355–62.
Schneider F, Fuchs H, Lorenz F, et al. A novel device for intravaginal electronic brachytherapy. Int J Radiat Oncol Biol Phys. 2009;74(4):1298–305.
Wenz F, Neumaier C, Schneider F, et al. Kypho-IORT - a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiat Oncol. 2010;11:5.
Acknowledgements
One of the authors (PJB) would like to thank Jessica Hiatt (Rhode Island Hospital) and Tom Rusch and Darius Francescatti (Xoft corporation) for useful comments on the Axxent system, Alan Sliski (Orbital Therapy) and Ken Harte for useful comments on the Intrabeam system and Bill Dundulis (Rhode Island Radiation Control Program) for his comments on regulatory matters.
One other author (UKT) wants to thank Frederik Wenz (University Medical Centre Mannheim, Germany) and Dietrich Wolf (Carl Zeiss Surgical) for their useful comments.
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Kraus-Tiefenbacher, U., Biggs, P., Vaidya, J., Francescatti, D. (2011). Electronic Brachytherapy/Low KV-IORT: Physics and Techniques. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_5
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