Abstract
Following the discovery that leukemic cells exhibit properties of hematopoietic stem cells, the prospective isolation of stem-like cells with high tumorigenicity has been reported for a variety of tumors. These “cancer stem cells” (CSCs) are so named because they exhibit the capacity for sustained self-renewal and possess the ability to regenerate transplanted tumor masses resembling the primary tumor in immunodeficient mice. However, the existence of CSCs remains contentious in the field of cancer biology, in part because of the application of inconsistent and inaccurate definitions and disputes over terminology. Herein, we review the discovery of CSCs, examine in detail their physical and functional characteristics, the mechanisms that lead to their formation, and how their contribution to solid tumor formation impacts cancer therapies.
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Abbreviations
- AML:
-
Acute myeloid leukemia
- APML:
-
Acute promyelocytic leukemia
- CML:
-
Chronic myeloid leukemia
- CSC:
-
Cancer stem cell
- ECM:
-
Extracellular matrix
- FACS:
-
Fluorescence-activated cell sorting
- HIF:
-
Hypoxia-inducible factor
- HSC:
-
Hematopoietic stem cell
- LSC:
-
Leukemic stem cell
- RGC:
-
Radial glial cells
- SSEA-1:
-
Stage-specific embryonic antigen 1
- SVZ:
-
Subventricular zone
- TNFAIP3:
-
Tumor necrosis factor inducible protein 3
- VEGF:
-
Vascular endothelial growth factor
References
Al-Hajj M, Wicha MS, Benito-Hernandez A et al (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983–3988
Alvero AB, Fu HH, Holmberg J et al (2009) Stem-like ovarian cancer cells can serve as tumor vascular progenitors. Stem Cells 27:2405–2013
Bailey P, Cushing H (1926) A Classification of the Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia: Lippincott
Bansal N, Banerjee D (2009) Tumor initiating cells. Curr Pharm Biotechnol 10:192–196
Bao S, Wu Q, Li Z et al (2008) Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res 68:6043–6048
Bao S, Wu Q, McLendon RE et al (2006a) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756–760
Bao S, Wu Q, Sathornsumetee S et al (2006b) Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66:7843–7848
Barker N, Ridgway RA, van Es JH et al (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457:608–611
Barr RD, Fialkow PJ (1973) Clonal origin of chronic myelocytic leukemia. N Engl J Med 289:307–309
Ben-Porath I, Thomson MW, Carey VJ et al (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499–507
Bertolini G, Roz L, Perego P et al (2009) Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci USA 106:16281–16286
Bertout JA, Patel SA, and Simon MC (2008). The impact of O2 availability on human cancer. Nat Rev Cancer 8:967–975
Bleau AM, Hambardzumyan D, Ozawa T et al (2009) PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4:226–235
Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730–737
Brecher G, Pallavicini MG, Cronkite EP (1993) Competitive repopulation in leukemic and normal bone marrow. Blood Cells 19:691–697
Brown D, Kogan S, Lagasse E et al (1997) A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:2551–2556
Calabrese C, Poppleton H, Kocak M et al (2007) A perivascular niche for brain tumor stem cells. Cancer Cell 11:69–82
Campos LS, Leone DP, Relvas JB et al (2004) Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development 131:3433–3444
Cao Y, Lathia JD, Eyler CE et al (2010) Erythropoietin receptor signaling through Stat3 is required for glioma stem cell maintenance. Genes Cancer 1:50–61
Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249–257
Ceteci F, Ceteci S, Karreman C et al (2007) Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. Cancer Cell 12:145–159
Chu P, Clanton DJ, Snipas TS et al (2009) Characterization of a subpopulation of colon cancer cells with stem cell-like properties. Int J Cancer 124:1312–1321
Chumsri S, Burger AM (2008) Cancer stem cell targeted agents: therapeutic approaches and consequences. Curr Opin Mol Ther 10:323–333
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, and Wahl GM (2006). Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66:9339–9344
Corbeil D, Röper K, Weigmann A et al (1998) AC133 hematopoietic stem cell antigen: human homologue of mouse kidney prominin or distinct member of a novel protein family? Blood 91:2625–2626
Curley MD, Therrien VA, Cummings CL et al (2009) CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells 27:2875–2883
de Groot JF, Yung WK (2008) Bevacizumab and irinotecan in the treatment of recurrent malignant gliomas. Cancer J 14:279–285
Dingli D, Michor F (2006) Successful therapy must eradicate cancer stem cells. Stem Cells 24:2603–2610
Du L, Wang H, He L et al (2008) CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 14:6751–6760.
Eyler CE, Foo WC, LaFiura KM et al (2008) Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 26:3027–3036
Fael Al-Mayhani TM, Ball SL, Zhao JW et al (2009) An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J Neurosci Methods 176:192–199
Fang D, Nguyen TK, Leishear K et al (2005) A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 65:9328–9337
Fang DD, Kim YJ, Lee CN et al (2010) Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery. Br J Cancer 102:1265–1275
Florian S, Sonneck K, Hauswirth AW et al (2006) Detection of molecular targets on the surface of CD34+/CD38– stem cells in various myeloid malignancies. Leuk Lymphoma 47:207–222
Folkins C, Shaked Y, Man S et al (2009) Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res 69:7243–7251
Fong CY, Chak LL, Subramanian A et al (2009) A three dimensional anchorage independent in vitro system for the prolonged growth of embryoid bodies to study cancer cell behaviour and anticancer agents. Stem Cell Rev 5:410–419
Forristal CE, Wright KL, Hanley NA et al (2010) Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction 139:85–97
Fujii E, Suzuki M, Matsubara K et al (2008) Establishment and characterization of in vivo human tumor models in the NOD/SCID/gamma(c)(null) mouse. Pathol Int 58:559–567
Fulci G, Ishii N, Maurici D et al (2002) Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion. Cancer Res 62:2897–2905
Gallia GL, Tyler BM, Hann CL et al (2009) Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther 8:386–393.
Gao JX (2008) Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med 12:67–96
Ginestier C, Hur MH, Charafe-Jauffret E et al (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555–567
Gottardi CJ, Wong E, Gumbiner BM (2001) E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 153:1049–1060
Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: mirage or reality? Nat Med 15:1010–1012
Hall PE, Lathia JD, Caldwell MA et al (2008) Laminin enhances the growth of human neural stem cells in defined culture media. BMC Neurosci 9:71
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Haraguchi N, Ohkuma M, Sakashita H et al (2008) CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol 15:2927–2933
Heddleston JM, Li Z, McLendon RE et al (2009) The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 8:3274–3284
Helczynska K, Kronblad A, Jögi A et al (2003) Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res 63:1441–1444
Held MA, Curley DP, Dankort D et al (2010) Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res 70:388–397
Hemmati HD, Nakano I, Lazareff JA et al (2003) Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100:15178–15183
Hirschmann-Jax C, Foster AE, Wulf GG et al (2004) A distinct “side population” of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci USA 101:14228–14233
Hjelmeland AB, Wu Q, Wickman S et al (2010) Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol 8(2):e1000319
Hu L, McArthur C, Jaffe RB (2010) Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer 102:1276–1283
Huang EH, Hynes MJ, Zhang T et al (2009) Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69:3382–3389
Iwasaki H, Suda T (2009) Cancer stem cells and their niche. Cancer Sci 100:1166–1172
Iyer NV, Leung SW, Semenza GL (1998) The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation. Genomics 52:159–165
Izumoto S, Ohnishi T, Arita N et al (1996) Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion. Cancer Res 56:1440–1444
Jamieson CH, Ailles LE, Dylla SJ et al (2004) Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351:657–667
Jin L, Hope KJ, Zhai Q et al (2006) Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 12:1167–1174
Komuro H, Saihara R, Shinya M et al (2007) Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. J Pediatr Surg 42:2040–2045
Krause DS, Lazarides K, von Andrian UH et al (2006) Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 12:1175–1180
Lacassagne A (1954) Anoxia as a factor of radioresistance. J Radiol Electrol Arch Electr Medicale 35:12–15
Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645–648
Lathia JD, Gallagher J, Heddleston JM, et al (2010). Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell 6:421–432
Lee J, Kotliarova S, Kotliarov Y et al (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391–403
Levings PP, McGarry SV, Currie TP et al (2009) Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res 69:5648–5655
Li C, Heidt DG, Dalerba P et al (2007) Identificationof pancreatic cancer stem cells. Cancer Res 67:1030–1037
Li L, Neaves WB (2006) Normal stem cells and cancer stem cells: the niche matters. Cancer Res 66:4553–4557
Li Z, Bao S, Wu Q et al (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501–513
Liu M, Casimiro MC, Wang C et al (2009) p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci USA 106:19035–19039
Lobo NA, Shimono Y, Qian D et al (2007) The biology of cancer stem cells. Annu Rev Cell Dev Biol 23:675–699
Ma L, Young J, Prabhala H et al (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12:247–256
Mammoto A, Ingber DE (2009) Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol 21:864–870
Mitsiades CS, Hideshima T, Chauhan D et al (2009) Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib. Semin Hematol 46:166–175
Moeller BJ, Cao Y, Li CY et al (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5:429–441
Morton CL, Houghton PJ (2007) Establishment of human tumor xenografts in immunodeficient mice. Nat Protoc 2:247–250
Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194:23–28
O’Brien CA, Pollett A, Gallinger S et al (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106–110
Pandit TS, Kennette W, Mackenzie L et al (2009) Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment. Int J Oncol 35:297–308
Passeguè E, Jamieson CH, Ailles LE et al (2003) Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA Suppl 1:11842–11849
Perez-Caro M, Cobaleda C, Gonz lez-Herrero I et al (2009) Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J 28:8–20
Platet N, Liu SY, Atifi ME et al (2007) Influence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett 258:286–290
Pollard SM, Yoshikawa K, Clarke ID et al (2009) Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 4:568–580
Puglisi MA, Sgambato A, Saulnier N et al (2009) Isolation and characterization of CD133+ cell population within human primary and metastatic colon cancer. Eur Rev Med Pharmacol Sci Suppl 1:55–62
Quintana E, Shackleton M, Sabel MS et al (2008) Efficient tumour formation by single human melanoma cells. Nature 456:593–598
Read TA, Fogarty MP, Markant SL et al (2009) Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15:135–147
Reya T, Morrison SJ, Clarke MF et al (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105–111
Ricci-Vitiani L, Lombardi DG, Pilozzi E et al (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445:111–115
Ropolo M, Daga A, Griffero F et al (2009) Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res 7:383–392
Saltz LB, Clarke S, DÌaz-Rubio E et al (2008) Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26:2013–2019
Seidel S, Garvalov BK, Wirta V et al (2010) A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2alpha. Brain 133:983–995
Sell S, Pierce GB (1994) Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers. Lab Invest 70:6–22
Semenza GL, Artemov D, Bedi A et al (2001) The metabolism of tumours’: 70 years later. Novartis Found Symp 240:251–260
Shen Q, Wang Y, Kokovay E et al (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3:289–300
Shukla V, Vaissière T, Herceg Z (2008) Histone acetylation and chromatin signature in stem cell identity and cancer. Mutat Res 637:1–15
Silván U, Díez-Torre A, Arluzea J et al (2009) Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology. Differentiation 78:159–168
Singh SK, Clarke ID, Terasaki M et al (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821–5828
Singh SK, Hawkins C, Clarke ID et al (2004) Identification of human brain tumour initiating cells. Nature 432:396–401
Sirard C, Lapidot T, Vormoor J et al (1996) Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 87:1539–1548
Soeda A, Park M, Lee D et al (2009) Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 28:3949–3959
Son MJ, Woolard K, Nam DH et al (2009) SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 4:440–452
Sottoriva A, Verhoeff JJ, Borovski T et al (2010) Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. Cancer Res 70:46–56
Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996
Sun Y, Pollard S, Conti L et al (2008) Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci 38:245–258
Sutherland HJ, Blair A, Zapf RW (1996) Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 87:4754–4761
Tamaki S, Eckert K, He D et al (2002) Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res 69:976–986
Tamase A, Muraguchi T, Naka K et al (2009) Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci USA 106:17163–17168
Taylor MD, Poppleton H, Fuller C et al (2005) Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 8:323–335
Teschendorff AE, Menon U, Gentry-Maharaj A et al (2010) Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 20:440–446
Tirino V, Camerlingo R, Franco R et al (2009) The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer. Eur J Cardiothorac Surg 36:446–453
Tirino V, Desiderio V, d’Aquino R et al (2008) Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLOS One 3:33469
Tomuleasa C, Soritau O, Rus-Ciuca D et al (2010) Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma. J Gastrointestin Liver Dis 19:61–67
Uchida N, Buck DW, He D et al (2000) Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 97:14720–14725
Virchow R (1963) Cellular pathology as based on physiological and pathological histology. J B Lippincott, Philadelphia
Voog J, Jones DL (2010) Stem cells and the niche: a dynamic duo. Cell Stem Cell 6:103–115
Wang H, Lathia JD, Wu Q et al (2009a) Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells 27:2393–2404
Wang J, Guo LP, Chen LZ et al (2007) Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res 67:3716–3724
Wang J, Wakeman TP, Lathia JD et al (2010) Notch promotes radioresistance of glioma stem cells. Stem Cells 28:17–28
Wang J, Wang H, Li Z et al (2008) c-Myc is required for maintenance of glioma cancer stem cells. PLoS One 3:e3769
Wang Y, Yang J, Zheng H et al (2009b) Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15:514–526
Wang YH, Li F, Luo B et al (2009c) A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics. Neoplasma 56:371–378
Ward RJ, Lee L, Graham K et al (2009) Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Res 69:4682–4690
Watt FM, Hogan BL (2000) Out of Eden: stem cells and their niches. Science 287:1427–1430
Widschwendter M, Fiegl H, Egle D et al (2007) Epigenetic stem cell signature in cancer. Nat Genet 39:157–158
Wright MH, Calcagno AM, Salcido CD et al (2008) Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics. Breast Cancer Res 10:R10
Yao J, Cai HH, Wei JS et al (2010) Side population in the pancreatic cancer cell lines SW1990 and CFPAC-1 is enriched with cancer stem-like cells. Oncol Rep 23:1375–1382
Yeung TM, Gandhi SC, Wilding JL et al (2010) Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci USA 107:3722–3727
Yuan Y, Zhou L, Miyamoto T et al (2001) AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci USA 98:10398–10403
Zhang M, Behbod F, Atkinson RL et al (2008) Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68:4674–4682
Zhou S, Schuetz JD, Bunting KD et al (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7:1028–1034
Zhu L, Gibson P, Currle DS et al (2009) Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457:603–607
Zhu Z, Hao X, Yan M et al (2010) Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer 126:2067–2078
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Eyler, C.E. et al. (2011). The Cancer Stem Cell Paradigm. In: Phinney, D. (eds) Adult Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-002-7_10
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