Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

Peng, Ye; Wang, Hong; Santana-Santos, Lucas; Kisker, Caroline; Van Houten, Bennett

doi:10.1007/978-1-61737-995-6_13

Ye Peng,
Hong Wang,
Lucas Santana-Santos,
Caroline Kisker &
…
Bennett Van Houten^2,3

Part of the book series: Current Cancer Research ((CUCR))

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7 Citations

Abstract

This chapter describes our present knowledge of nucleotide excision repair (NER) in both prokaryotic and eukaryotic organisms. NER is a generalized repair system capable of removing a wide range of DNA lesions differing in their shape and chemistry. Advances in the structure–function of the proteins that mediate this repair process have given a rich understanding of the key molecular steps that include the following: damage detection, damage verification, incision, repair synthesis, and ligation. The first section of this chapter examines prokaryotic NER, which is mediated by six proteins. The same process in eukaryotic cells requires over 30 proteins, which is covered in the next section. The chapter ends with a brief description of several human diseases that are caused by the loss of NER protein activity.

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Acknowledgments

We apologize to all our colleagues working in this field for any omissions or lack of citations due to space limitations. We thank Drs. Vesna Rapic-Ortrin, Li Lan, and Satoshi Nakajima along with Amy Furda at Hillman Cancer Institute, University of Pittsburgh Medical Center for helpful suggestions and comments. This work was supported by UPCI-startup and NIH grant, 1R01ES019566-01 (BVH), the Deutsche Forschungsgemeinschaft (KI-562/2-1 and Forschungszentrum FZ-82) (CK) and K99ES016758-01 (HW). A new structure of a UvrA-DNA complex was recently published, and is very similar to the predicted structure shown in Figure 6e; Nowak, J.M. et al, (2011) Nat. Struct. Mol. Biol. 2:191–7.

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Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA
Bennett Van Houten
University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA
Bennett Van Houten

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Ye Peng
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Hong Wang
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Lucas Santana-Santos
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Caroline Kisker
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School of Medicine, Dept. Pharmacology, University of Pennsylvania, Hamilton Walk 3260, Philadelphia, 19104, Pennsylvania, USA
Trevor M. Penning

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Peng, Y., Wang, H., Santana-Santos, L., Kisker, C., Van Houten, B. (2011). Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies. In: Penning, T. (eds) Chemical Carcinogenesis. Current Cancer Research. Humana Press. https://doi.org/10.1007/978-1-61737-995-6_13

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DOI: https://doi.org/10.1007/978-1-61737-995-6_13
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