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MPTP and Oxidative Stress: It’s Complicated!

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Studies on Experimental Models

Abstract

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the tool of choice for modeling Parkinson’s Disease (PD) in animals. Originally synthesized as a “designer drug” by drug users, MPTP, while not giving us the definitive answer as to the etiology of Parkinson’s disease, has enlightened many of us researchers about the molecules and mechanisms involved in dopamine neuron death. Herein, we provide information about some of the events that are involved here and try to make it clear just how complicated the death of the dopamine neuron in the MPTP model and possibly in PD seems to be.

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Authors and Affiliations

  1. Center for Motor Neuron Biology and Disease, Departments of Neurology, Columbia University, Room 4-401, 630 West 168th Street, New York, NY, 10032, USA

    V. Jackson-Lewis

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  1. V. Jackson-Lewis
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  2. M. A. Tocilescu
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  3. R. DeVries
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  4. D. M. Alessi
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  5. S. Przedborski
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Correspondence to V. Jackson-Lewis .

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  1. Dept. Health & Caring Sciences, University Uppsala, Döbelnsgatan 2, Uppsala, 752 37, Sweden

    Samar Basu

  2. Dept. Surgical Sciences, Anaesthesiology, & Intensive Care, Uppsala University Hospital, Akademiska Sjukhuset, Uppsala, 751 85, Sweden

    Lars Wiklund

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Jackson-Lewis, V., Tocilescu, M.A., DeVries, R., Alessi, D.M., Przedborski, S. (2011). MPTP and Oxidative Stress: It’s Complicated!. In: Basu, S., Wiklund, L. (eds) Studies on Experimental Models. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-956-7_8

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