MPTP and Oxidative Stress: It’s Complicated!

  • V. Jackson-LewisEmail author
  • M. A. Tocilescu
  • R. DeVries
  • D. M. Alessi
  • S. Przedborski
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the tool of choice for modeling Parkinson’s Disease (PD) in animals. Originally synthesized as a “designer drug” by drug users, MPTP, while not giving us the definitive answer as to the etiology of Parkinson’s disease, has enlightened many of us researchers about the molecules and mechanisms involved in dopamine neuron death. Herein, we provide information about some of the events that are involved here and try to make it clear just how complicated the death of the dopamine neuron in the MPTP model and possibly in PD seems to be.


Cytokines Dopamine Mitochondria Monoamine oxidase MPTP Nitric oxide Superoxide 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • V. Jackson-Lewis
    • 1
    Email author
  • M. A. Tocilescu
  • R. DeVries
  • D. M. Alessi
  • S. Przedborski
  1. 1.Center for Motor Neuron Biology and Disease, Departments of NeurologyColumbia UniversityNew YorkUSA

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