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In vivo Imaging of Antioxidant Effects on NF-κB Activity in Reporter Mice

  • Ingvild Paur
  • Harald Carlsen
  • Rune BlomhoffEmail author
Chapter
  • 1.1k Downloads
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

In this chapter, we describe how we have utilized transgenic reporter mice and cell lines to investigate how phytochemicals/antioxidants and dietary plants can modulate NF-κB transcription factor activity. Several dietary plants are found to be potent modulators of NF-κB activity in vivo. Even though these dietary plants are rich in antioxidants/phytochemicals, the contribution of antioxidant properties per se, to these effects on NF-κB remain uncertain. Also, the relationship and interactions between antioxidants/ROS and the NF-κB signalling pathway is complex and still not fully elicidated. In line with this discussion, we find different dietary plants to be able to both inhibit and induce NF-κB activity, and we speculate that both might contribute to the preventive effects of diets rich in plant-based foods towards chronic diseases.

Keywords

In vivo imaging NF-κB Nutrition Phytochemicals ROS 

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Nutrition, Institute of Basic Medical SciencesUniversity of OsloOsloNorway

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