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In vivo Imaging of Antioxidant Effects on NF-κB Activity in Reporter Mice

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Abstract

In this chapter, we describe how we have utilized transgenic reporter mice and cell lines to investigate how phytochemicals/antioxidants and dietary plants can modulate NF-κB transcription factor activity. Several dietary plants are found to be potent modulators of NF-κB activity in vivo. Even though these dietary plants are rich in antioxidants/phytochemicals, the contribution of antioxidant properties per se, to these effects on NF-κB remain uncertain. Also, the relationship and interactions between antioxidants/ROS and the NF-κB signalling pathway is complex and still not fully elicidated. In line with this discussion, we find different dietary plants to be able to both inhibit and induce NF-κB activity, and we speculate that both might contribute to the preventive effects of diets rich in plant-based foods towards chronic diseases.

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  1. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, 0316, Oslo, Norway

    Rune Blomhoff

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  1. Ingvild Paur
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  2. Harald Carlsen
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  3. Rune Blomhoff
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Correspondence to Rune Blomhoff .

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  1. Dept. Health & Caring Sciences, University Uppsala, Döbelnsgatan 2, Uppsala, 752 37, Sweden

    Samar Basu

  2. Dept. Surgical Sciences, Anaesthesiology, & Intensive Care, Uppsala University Hospital, Akademiska Sjukhuset, Uppsala, 751 85, Sweden

    Lars Wiklund

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Paur, I., Carlsen, H., Blomhoff, R. (2011). In vivo Imaging of Antioxidant Effects on NF-κB Activity in Reporter Mice. In: Basu, S., Wiklund, L. (eds) Studies on Experimental Models. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-956-7_7

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