Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Skeletal Muscle

  • Malcolm J. JacksonEmail author
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Reactive oxygen and nitrogen species are generated in increased amounts in skeletal muscle during contractile activity, but most techniques to study this area have utilized end point analyses and are influenced by non-muscle cells present in the sample. This review will briefly examine the various alternative models that can be used to overcome these problems and help determine the potentially important roles that ROS appear to play in physiological and pathological processes in muscle.


Reactive oxygen species Skeletal muscle Microdialysis Cell culture Fluorescence microscopy 


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.School of Clinical SciencesUniversity of LiverpoolLiverpoolUK

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