An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion

  • Lars WiklundEmail author
  • Samar Basu
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Despite many programs aimed at better immediate care of cardiac arrest victims, the subsequent mortality rate remains high, with myocardial and central nervous system injuries as the most common causes of death. Preclinical research is badly needed to produce a sound base for future clinical trials and possible improvements in clinical outcome. Our continued use of a porcine model for studies of cerebral effects of anoxia and reperfusion has shown that this model results in standardized effects, where time of cardiac arrest and reperfusion are approximately proportional to the ischemic neurological injury. Free radical damage is proved to be an important pathophysiological mechanism in the early development of this nervous injury. Hence, not unexpectedly, early experimental treatment after total ischemia during early reperfusion results in improved measures of cerebral tissue damage.


Brain CPR Inflammation Ischemia–reperfusion Isoprostanes Neurology Oxidative stress Prostaglandins 



Continued financial support over the years from The Laerdal Foundation for Acute Medicine is gratefully acknowledged.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Surgical Sciences/Anaesthesiology and Intensive Care MedicineUppsala UniversityUppsalaSweden

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