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Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells

  • Olivier C. Maes
  • Howard M. Chertkow
  • Eugenia WangEmail author
  • Hyman M. SchipperEmail author
Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Alzheimer’s disease (AD) is a primary degenerative brain disorder that also affects peripheral tissues such as peripheral blood mononuclear cells (PBMC). Several hypotheses for the pathogenesis of AD are intrinsically related to mechanisms of aging and include excitotoxicity, neuroinflammation, mitochondrial dysfunction, and enhanced oxidative stress. Delineation of biochemical alterations in AD blood components may provide insights into the pathogenesis of sporadic AD and facilitate the development of diagnostic and prognostic biomarkers. Here we describe our published experimental approaches and PBMC gene expression data in sporadic AD, with emphasis on the role of altered redox homeostasis in the development of this common affliction.

Keywords

Alzheimer’s disease Gene expression Oxidative stress Peripheral blood mononuclear cells 

Notes

Acknowledgment

The content of this chapter is a collection of previously published material, with permission from Elsevier (Neurobiology of Aging, 28/12, Maes et al., Transcriptional profiling of Alzheimer blood mononuclear cells by microarray, pp. 1795–1809, 2007) and Oxford University Press (Journal of Gerontology, Series A, 64(6), Maes et al., Methodology for Discovery of Alzheimer’s Disease Blood-Based Biomarkers, pp. 636–645, 2009). The work was supported by an internal grant from the Sir Mortimer B. Davis-Jewish General Hospital (JGH). The authors gratefully acknowledge the contribution of the medical staff, neuropsychologists, nurses, patients, research coordinators and secretaries of the JGH-McGill Memory Clinic.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gheens Center on Aging, and Department of Biochemistry and Molecular Biology, School of MedicineUniversity of LouisvilleLouisvilleUSA
  2. 2.Bloomfield Centre for Research in AgingLady Davis Institute for Medical ResearchMontréalCanada
  3. 3.Departments of Neurology, Neurosurgery and Medicine (Geriatrics)McGill UniversityMontréalCanada

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