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Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models

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5-HT2C Receptors in the Pathophysiology of CNS Disease

Part of the book series: The Receptors ((REC,volume 22))

Abstract

Advances in cellular and molecular biology now allow investigators to generate small DNA constructs that can be substituted for specific genomic loci in mouse embryonic stem cells. The transgenic mice that are derived from embryos implanted with these engineered stem cells are powerful models for understanding protein function at molecular, cellular, tissue, and in vivo behavior levels of organization. Mice engineered to express serotonin-2C receptors (5-HT2CRs) of different functional characteristics have provided key insights into molecular processes ranging from posttranscriptional editing of messenger RNA to regulation of neurotransmitter receptor activity and sensitization. These models also suggest that 5-HT2CRs are key regulators of many important cognitive, emotional, and functional (e.g., maintenance of energy balance) behaviors. 5-HT2CR function has also been linked to a number of clinically important disease states, including those involving resilience to stress, obesity, movement disorders, and seizure disorders. This review will focus on the different lines of evidence that have come from mice with engineered 5-HT2CRs, and how these models have advanced current concepts linking the regulation of neuronal excitation to coordinated performance of multiple behavioral processes.

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  1. Department of Medicine/Division of Geriatrics, University of Nebraska Medical Center, Omaha, NE, 68190-5039, USA

    Stephen J. Bonasera

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  1. Stephen J. Bonasera
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Correspondence to Stephen J. Bonasera .

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  1. , Department of Physiology and Biochemistr, University of Malta, Msida, Malta, MSD 2080, Italy

    Giuseppe Di Giovanni

  2. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Ennio Esposito

  3. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Vincenzo Di Matteo

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Bonasera, S.J. (2011). Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models. In: Di Giovanni, G., Esposito, E., Di Matteo, V. (eds) 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors, vol 22. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-941-3_4

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