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The Constitutive Activity of 5-HT2C Receptors as an Additional Modality of Interaction of the Serotonergic System

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5-HT2C Receptors in the Pathophysiology of CNS Disease

Part of the book series: The Receptors ((REC,volume 22))

Abstract

Neurotransmitters usually interact with their receptors in a phasic and/or tonic manner. Additionally, numerous G-protein-coupled receptors display a constitutive activity that spontaneously activates intracellular pathways independently from the presence of the endogenous neurotransmitter. Although such multiple modalities of action have been clearly described in vitro, the transposition of the concept of constitutive activity to the living animals remains controversial. The constitutive activity would be a physiological property of 5-HT2C receptors in basal ganglia, a group of subcortical brain regions involved in motor control. This activity has been deeply investigated in the control of in vivo dopamine release and occurs concomitantly to the phasic and tonic inhibitory controls exerted by 5-HT2C receptors. Nevertheless, the regional distribution of each of these controls may be different in basal ganglia. A constitutive activity of 5-HT2C receptors may participate in fine in numerous brain functions concomitantly to phasic and tonic influences, if a full pharmacological characterization is obtained.

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  1. Laboratoire Mouvement Adaptation Cognition - UMR CNRS 5227, Université Victor Segalen Bordeaux, 2146 rue Léo Saignât, Zone Nord, Bât. 2A, 33076, Bordeaux, France

    Sylvia Navailles

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  1. Sylvia Navailles
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  2. Philippe De Deurwaerdère
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Correspondence to Sylvia Navailles .

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  1. , Department of Physiology and Biochemistr, University of Malta, Msida, Malta, MSD 2080, Italy

    Giuseppe Di Giovanni

  2. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Ennio Esposito

  3. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Vincenzo Di Matteo

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Navailles, S., De Deurwaerdère, P. (2011). The Constitutive Activity of 5-HT2C Receptors as an Additional Modality of Interaction of the Serotonergic System. In: Di Giovanni, G., Esposito, E., Di Matteo, V. (eds) 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors, vol 22. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-941-3_10

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