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Stem Cells & Regenerative Medicine pp 565–578Cite as

Muscle-Derived Stem Cells: A Model for Stem Cell Therapy in Regenerative Medicine

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Our research group has shown that a population of muscle-derived stem cells (MDSCs) isolated by a modified preplate technique from murine postnatal skeletal muscle displays a high transplantation capacity in both ­skeletal and cardiac muscles. The ability of MDSCs to proliferate in vivo for an extended period of time, combined with their strong capacity for self-renewal, resistance to stress, ­ability to undergo multilineage differentiation, ability to induce neovascularization and the paracrine effects that they have on the host, at least partially explains the high regenerative capacity of these cells in vivo. Although the true origin of MDSCs is unclear, the similarity to human blood vessel–derived stem cells suggests a ­putative origin from the vascular wall. This chapter reviews current knowledge on the utility of the MDSCs to improve the healing of various musculoskeletal tissues and injured cardiac muscle and lists the potential clinical applications based on this knowledge. We propose that these cells are a successful model for the use in regenerative medicine but emphasize that other factors, such as age and sex of the host and donor cells, should be considered.

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Authors and Affiliations

  1. Departments of Orthopaedic Surgery and Molecular Genetics and Biochemistry, and Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, 15219, USA

    Johnny Huard

Authors
  1. Burhan Gharaibeh
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  2. Lauren Drowley
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  3. Johnny Huard
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Corresponding author

Correspondence to Johnny Huard .

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Editors and Affiliations

  1. Gene Expression Systems, Inc., Waltham, Massachusetts, USA

    Krishnarao Appasani

  2. Student Science, Wyllys Ave 45, Middletown, 06459, Connecticut, USA

    Raghu K. Appasani

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Gharaibeh, B., Drowley, L., Huard, J. (2011). Muscle-Derived Stem Cells: A Model for Stem Cell Therapy in Regenerative Medicine. In: Appasani, K., Appasani, R. (eds) Stem Cells & Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-860-7_34

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