Mesenchymal Stem Cells for Acute Lung Injury

  • Jae W. LeeEmail author
  • Naveen Gupta
  • Michael A. Matthay
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Despite extensive research into the pathogenesis of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), mortality remains high, approaching 30% even with lung-protective ventilation and a fluid conservative strategy. Pharmacologic therapies that reduce the severity of lung injury in vivo and in vitro have not yet been translated into effective clinical treatment options. Therefore, innovative therapies are needed. Recent studies have suggested that bone-marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in multiple clinical disorders, including myocardial infarction, diabetes, sepsis, hepatic failure, and acute renal failure. Recently, MSCs have been studied in several in vivo models of lung disease. This review focuses first on describing the existing experimental literature that has tested the use of MSCs in models of ALI/ARDS, and then on describing the potential mechanisms underlying their therapeutic use with an emphasis on secreted paracrine soluble factors.


Acute respiratory distress syndrome Mesenchymal stem cells Paracrine soluble factors Pulmonary edema 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jae W. Lee
    • 1
    Email author
  • Naveen Gupta
    • 2
  • Michael A. Matthay
    • 1
    • 2
  1. 1.Departments of Medicine and AnesthesiologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Cardiovascular Research InstituteUniversity of CaliforniaSan FranciscoUSA

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