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Sleep and Lung Disease

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Essentials of Sleep Medicine

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Sleep disturbances are common in many respiratory disorders, including chronic obstructive pulmonary disease (COPD), asthma, and restrictive lung disease. Sleep is, in many ways, a time of vulnerability in respiratory illness. Changes in upper airway resistance and, at times, lower airway resistance, may exacerbate underlying pulmonary conditions. Sleep is also a time when hypoxemia may worsen, and this may impose its own associated health hazards. Since COPD and asthma are very common conditions, the burden of sleep-related physiological stress leads to a significant burden in terms of the number of people affected. Sleep in patients with less common lung diseases, such as restrictive disorders and obesity-hypoventilation syndrome, show different patterns of physiological abnormalities during sleep. In this chapter we will explore of the intersection between sleep and these important pulmonary medicine conditions.

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References

  1. Niewoehner D. Outpatient management of severe COPD. NEJM. 2010;362:1407–16.

    Article  PubMed  CAS  Google Scholar 

  2. Han M, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med. 2010;182:598–604.

    Article  PubMed  Google Scholar 

  3. Becker H, Piper A, Flynn W, et al. Breathing during in patients with nocturnal desaturation. Am J Respir Crit Care Med. 1999;159:112–8.

    PubMed  CAS  Google Scholar 

  4. Ballard RD, Clover CW, Suh BY. Influence of sleep on respiratory function in emphysema. Am J Respir Crit Care Med. 1995;151:945–51.

    PubMed  CAS  Google Scholar 

  5. George C, West P, Kryger MH. Oxygenation and breathing pattern during phasic and tonic REM in patients with chronic obstructive pulmonary disease. Sleep. 1987;10:234–43.

    PubMed  CAS  Google Scholar 

  6. Mohsenin V. Sleep in chronic obstructive pulmonary disease. Semin Respir Crit Care Med. 2005;26:109–16.

    Article  PubMed  Google Scholar 

  7. Midgren B. Oxygen desaturation during sleep as a function of the underlying respiratory disease. Am Rev Respir Dis. 1990;141:43–6.

    PubMed  CAS  Google Scholar 

  8. Catterall JR, Calverley PM, MacNee W, et al. Mechanism of transient nocturnal hypoxemia in hypoxic chronic bronchitis and emphysema. J Appl Physiol. 1985;59:1698–703.

    PubMed  CAS  Google Scholar 

  9. Boysen PG, Block AJ, Wynne JW, Hunt LA, Flick MR. Nocturnal pulmonary hypertension in patients with chronic obstructive pulmonary disease. Chest. 1979;76:536–42.

    Article  PubMed  CAS  Google Scholar 

  10. Coccagna G, Lugaresi E. Arterial blood gases and pulmonary and systemic arterial pressure during sleep in chronic obstructive pulmonary disease. Sleep. 1978;1:117–24.

    PubMed  CAS  Google Scholar 

  11. Moore-Gillon JC, Cameron IR. Right ventricular hypertrophy and polycythaemia in rats after intermittent exposure to hypoxia. Clin Sci (Lond). 1985;69:595–9.

    CAS  Google Scholar 

  12. Fleetham J, West P, Mezon B, et al. Sleep, arousals, and oxygen desaturation in chronic obstructive pulmonary disease. The effect of oxygen therapy. Am Rev Respir Dis. 1982;126:429–33.

    PubMed  CAS  Google Scholar 

  13. Shepard Jr JW, Garrison MW, Grither DA, Dolan GF. Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest. 1985;88:335–40.

    Article  PubMed  Google Scholar 

  14. Calverley PM, Brezinova V, Douglas NJ, Catterall JR, Flenley DC. The effect of oxygenation on sleep quality in chronic bronchitis and emphysema. Am Rev Respir Dis. 1982;126:206–10.

    PubMed  CAS  Google Scholar 

  15. Connaughton JJ, Catterall JR, Elton RA, Stradling JR, Douglas NJ. Do sleep studies contribute to the management of patients with severe chronic obstructive pulmonary disease? Am Rev Respir Dis. 1988;138:341–4.

    PubMed  CAS  Google Scholar 

  16. Connaughton JJ, Douglas NJ, Morgan AD, et al. Almitrine improves oxygenation when both awake and asleep in patients with hypoxia and carbon dioxide retention caused by chronic bronchitis and emphysema. Am Rev Respir Dis. 1985;132:206–10.

    PubMed  CAS  Google Scholar 

  17. Series F, Cormier Y. Effects of protriptyline on diurnal and nocturnal oxygenation in patients with chronic obstructive pulmonary disease. Ann Intern Med. 1990;113:507–11.

    PubMed  CAS  Google Scholar 

  18. Dolly FR, Block AJ. Medroxyprogesterone acetate and COPD. Effect on breathing and oxygenation in sleeping and awake patients. Chest. 1983;84:394–8.

    Article  PubMed  CAS  Google Scholar 

  19. Lin CC. Comparison between nocturnal nasal positive pressure ventilation combined with oxygen therapy and oxygen monotherapy in patients with severe COPD. Am J Respir Crit Care Med. 1996;154:353–8.

    PubMed  CAS  Google Scholar 

  20. Meecham Jones DJ, Paul EA, Jones PW, Wedzicha JA. Nasal pressure support ventilation plus oxygen compared with oxygen therapy alone in hypercapnic COPD. Am J Respir Crit Care Med. 1995;152:538–44.

    PubMed  CAS  Google Scholar 

  21. Weitzenblum E, Chaouat A, Kessler R, Canuet M. Overlap syndrome: obstructive sleep apnea in patients with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5:237–41.

    Article  PubMed  Google Scholar 

  22. Fletcher EC, Miller J, Divine GW, Fletcher JG, Miller T. Nocturnal oxyhemoglobin desaturation in COPD patients with arterial oxygen tensions above 60 mm Hg. Chest. 1987;92:604–8.

    Article  PubMed  CAS  Google Scholar 

  23. Sanders MH, Newman AB, Haggerty CL, et al. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med. 2003;167:7–14.

    Article  PubMed  Google Scholar 

  24. Hetzel MR, Clark TJ. Comparison of normal and asthmatic circadian rhythms in peak ­expiratory flow rate. Thorax. 1980;35:732–8.

    Article  PubMed  CAS  Google Scholar 

  25. Ballard RD, Saathoff MC, Patel DK, Kelly PL, Martin RJ. Effect of sleep on nocturnal bronchoconstriction and ventilatory patterns in asthmatics. J Appl Physiol. 1989;67:243–9.

    PubMed  CAS  Google Scholar 

  26. Barnes P, FitzGerald G, Brown M, Dollery C. Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. N Engl J Med. 1980;303:263–7.

    Article  PubMed  CAS  Google Scholar 

  27. Clark TJ, Hetzel MR. Diurnal variation of asthma. Br J Dis Chest. 1977;71:87–92.

    Article  PubMed  CAS  Google Scholar 

  28. Mackay TW, Wallace WA, Howie SE, et al. Role of inflammation in nocturnal asthma. Thorax. 1994;49:257–62.

    Article  PubMed  CAS  Google Scholar 

  29. Jarjour NN, Busse WW, Calhoun WJ. Enhanced production of oxygen radicals in nocturnal asthma. Am Rev Respir Dis. 1992;146:905–11.

    PubMed  CAS  Google Scholar 

  30. Martin RJ, Cicutto LC, Smith HR, Ballard RD, Szefler SJ. Airways inflammation in nocturnal asthma. Am Rev Respir Dis. 1991;143:351–7.

    PubMed  CAS  Google Scholar 

  31. Fitzpatrick MF, Engleman H, Whyte KF, Deary IJ, Shapiro CM, Douglas NJ. Morbidity in nocturnal asthma: sleep quality and daytime cognitive performance. Thorax. 1991;46:569–73.

    Article  PubMed  CAS  Google Scholar 

  32. Teodorescu M, Consens FB, Bria WF, et al. Correlates of daytime sleepiness in patients with asthma. Sleep Med. 2006;7:607–13.

    Article  PubMed  Google Scholar 

  33. Weersink EJ, van Zomeren EH, Koeter GH, Postma DS. Treatment of nocturnal airway obstruction improves daytime cognitive performance in asthmatics. Am J Respir Crit Care Med. 1997;156:1144–50.

    PubMed  CAS  Google Scholar 

  34. Fitzpatrick MF, Engleman HM, Boellert F, et al. Effect of therapeutic theophylline levels on the sleep quality and daytime cognitive performance of normal subjects. Am Rev Respir Dis. 1992;145:1355–8.

    PubMed  CAS  Google Scholar 

  35. Fitzpatrick MF, Mackay T, Driver H, Douglas NJ. Salmeterol in nocturnal asthma: a double blind, placebo controlled trial of a long acting inhaled beta 2 agonist. BMJ. 1990;301:1365–8.

    Article  PubMed  CAS  Google Scholar 

  36. Guilleminault C, Kurland G, Winkle R, Miles LE. Severe kyphoscoliosis, breathing, and sleep: the “Quasimodo” syndrome during sleep. Chest. 1981;79:626–30.

    Article  PubMed  CAS  Google Scholar 

  37. Mezon BL, West P, Israels J, Kryger M. Sleep breathing abnormalities in kyphoscoliosis. Am Rev Respir Dis. 1980;122:617–21.

    PubMed  CAS  Google Scholar 

  38. Berger KI, Ayappa I, Chatr-Amontri B, et al. Obesity hypoventilation syndrome as a spectrum of respiratory disturbances during sleep. Chest. 2001;120:1231–8.

    Article  PubMed  CAS  Google Scholar 

  39. Piper AJ, Grunstein RR. Obesity hypoventilation syndrome: mechanisms and management. Am J Respir Crit Care Med. 2011;183:292–8.

    Article  PubMed  Google Scholar 

  40. Lourenco RV, Turino GM, Davidson LA, Fishman AP. The regulation of ventilation in diffuse pulmonary fibrosis. Am J Med. 1965;38:199–216.

    Article  PubMed  CAS  Google Scholar 

  41. Perez-Padilla R, West P, Lertzman M, Kryger MH. Breathing during sleep in patients with interstitial lung disease. Am Rev Respir Dis. 1985;132:224–9.

    PubMed  CAS  Google Scholar 

  42. Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med. 1980;93:391–8.

    Google Scholar 

  43. Berger KI, Goldring RM, Rapoport DM. Obesity hypoventilation syndrome. Semin Respir Crit Care Med. 2009;30:253–61.

    Article  PubMed  Google Scholar 

  44. Burki NK, Baker RW. Ventilatory regulation in eucapnic morbid obesity. Am Rev Respir Dis. 1984;129:538–43.

    PubMed  CAS  Google Scholar 

  45. Lopata M, Onal E. Mass loading, sleep apnea, and the pathogenesis of obesity hypoventilation. Am Rev Respir Dis. 1982;126:640–5.

    PubMed  CAS  Google Scholar 

  46. Sampson MG, Grassino K. Neuromechanical properties in obese patients during carbon dioxide rebreathing. Am J Med. 1983;75:81–90.

    Article  PubMed  CAS  Google Scholar 

  47. Tankersley CG, O’Donnell C, Daood MJ, et al. Leptin attenuates respiratory complications associated with the obese phenotype. J Appl Physiol. 1998;85:2261–9.

    PubMed  CAS  Google Scholar 

  48. Phipps PR, Starritt E, Caterson I, Grunstein RR. Association of serum leptin with hypoventilation in human obesity. Thorax. 2002;57:75–6.

    Article  PubMed  CAS  Google Scholar 

  49. Shimura R, Tatsumi K, Nakamura A, et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest. 2005;127:543–9.

    Article  PubMed  CAS  Google Scholar 

  50. Berg G, Delaive K, Manfreda J, Walld R, Kryger MH. The use of health-care resources in obesity-hypoventilation syndrome. Chest. 2001;120:377–83.

    Article  PubMed  CAS  Google Scholar 

  51. Windisch W. Impact of home mechanical ventilation on health-related quality of life. Eur Respir J. 2008;32:1328–36.

    Article  PubMed  CAS  Google Scholar 

  52. Sugerman HJ, Fairman RP, Baron PL, Kwentus JA. Gastric surgery for respiratory insufficiency of obesity. Chest. 1986;90:81–6.

    Article  PubMed  CAS  Google Scholar 

  53. Greenburg DL, Lettieri CJ, Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med. 2009;122:535–42.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Sleep Disorders Program, Pulmonary and Sleep Section, VA Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA, 15240, USA

    Charles W. Atwood Jr.

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  1. Charles W. Atwood Jr.
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Correspondence to Charles W. Atwood Jr. .

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Editors and Affiliations

  1. Harper University Hospital, Div. Pulmonary, Allergy, Critical, Wayne State University, John R. Street 3990, Detroit, 48201, Michigan, USA

    M. Safwan Badr

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Atwood, C.W. (2012). Sleep and Lung Disease. In: Badr, M. (eds) Essentials of Sleep Medicine. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-735-8_11

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  • DOI: https://doi.org/10.1007/978-1-60761-735-8_11

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-734-1

  • Online ISBN: 978-1-60761-735-8

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