Metabolic and Hormonal Regulation During Sleep

  • Riva TaumanEmail author
Part of the Respiratory Medicine book series (RM)


Sleep plays a major role in the regulation of metabolic and endocrine functions. Reproducible changes in the release of pituitary hormones and pituitary-dependent hormones occur during sleep and reflect the interactions between the three sleep regulatory processes, namely the homeostatic, circadian, and ultradian processes. The prevalence of sleep curtailment, obesity, and metabolism-related pathologies is increasing worldwide. Experimental evidence supports an association between sleep shortening and chronic metabolic changes that can lead to obesity and diabetes. Brain circuits regulating both sleep and metabolism may underlie these associations. Sleep curtailment is also suggested to be a chronic stressor that may contribute to increased risk of obesity and metabolic diseases, possibly in part through HPA axis dysregulation. The hypothalamic excitatory neuropeptides, hypocretin/orexin, have potent wake-promoting effects and act to stimulate food intake. These peptides are involved in the interactions between sleep–wake regulation and the neuroendocrine control of appetite. Western lifestyle has major impact on sleep, eating, and activity periods. Growing evidence suggests that this lifestyle, which is accompanied by disrupted biological rhythms, might affect metabolism leading to metabolic morbidities such as obesity and diabetes.


Circadian Rhythm Sleep Deprivation Circadian Clock Growth Hormone Secretion Ghrelin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Sleep Disorder Center, Dana Children’s Hospital, Tel Aviv Medical CenterTel AvivIsrael

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