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Metabolic and Hormonal Regulation During Sleep

  • Riva TaumanEmail author
Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

Sleep plays a major role in the regulation of metabolic and endocrine functions. Reproducible changes in the release of pituitary hormones and pituitary-dependent hormones occur during sleep and reflect the interactions between the three sleep regulatory processes, namely the homeostatic, circadian, and ultradian processes. The prevalence of sleep curtailment, obesity, and metabolism-related pathologies is increasing worldwide. Experimental evidence supports an association between sleep shortening and chronic metabolic changes that can lead to obesity and diabetes. Brain circuits regulating both sleep and metabolism may underlie these associations. Sleep curtailment is also suggested to be a chronic stressor that may contribute to increased risk of obesity and metabolic diseases, possibly in part through HPA axis dysregulation. The hypothalamic excitatory neuropeptides, hypocretin/orexin, have potent wake-promoting effects and act to stimulate food intake. These peptides are involved in the interactions between sleep–wake regulation and the neuroendocrine control of appetite. Western lifestyle has major impact on sleep, eating, and activity periods. Growing evidence suggests that this lifestyle, which is accompanied by disrupted biological rhythms, might affect metabolism leading to metabolic morbidities such as obesity and diabetes.

Keywords

Circadian Rhythm Sleep Deprivation Circadian Clock Growth Hormone Secretion Ghrelin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Valdhuis JD, Iranmanesh A, Weltman A. Elements in the pathophysiology of diminished growth hormone secretion in aging humans. Endocrine. 1997; 7(1):41–8.Google Scholar
  2. 2.
    Muccioli G, Tschöp M, Papotti M, et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. 2002;440:235–54.PubMedGoogle Scholar
  3. 3.
    Van Cauter E. Endocrine physiology. In: Krieger MH, Dement WC, Roth T, editors. Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier Saunders; 2005. p. 266–82.Google Scholar
  4. 4.
    Sassin JF, Parker DC, Mace JW, et al. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science. 1969;165:513–5.PubMedGoogle Scholar
  5. 5.
    Dzaja A, Dalal M, Himmerich H, et al. Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Am J Physiol Endocrinol Metab. 2004; 286:963–7.Google Scholar
  6. 6.
    Gronfier C, Luthringer R, Follenius M, et al. A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep. 1996;19: 817–24.PubMedGoogle Scholar
  7. 7.
    Van Cauter E, Caufriez A, Kerkhofs M, et al. Sleep, awakenings and insulin-like growth factor 1 modulate the growth hormone secretory response to growth hormone-releasing hormone. J Clin Endocrinol Metab. 1992;74:1451–9.PubMedGoogle Scholar
  8. 8.
    Weikel JC, Wchniak A, Ising M, et al. Ghrelin promotes sloe-wave sleep in humans. Am J Physiol Endocrinol Metab. 2003;284:e407–15.PubMedGoogle Scholar
  9. 9.
    Van Cauter E, Plat L, Copinschi G. Interrelations between sleep and the somatotropic axis. Sleep. 1998;21:553–66.PubMedGoogle Scholar
  10. 10.
    Sheldon SH. Physiologic variations during sleep in children. In: Sheldon SH, Ferber R, Kryger MH, editors. Principles and practice of pediatric sleep medicine. 1st ed. Philadelphia: Elsevier Saunders; 2005. p. 73–84.Google Scholar
  11. 11.
    Gronfier C, Luthringer R, Follenius M, et al. Temporal relationships between pulsatile cortisol secretion and electroencephalographic activity during sleep in men. Electroencephalogr Clin Neurophysiol. 1997;103:405–8.PubMedGoogle Scholar
  12. 12.
    Bierwolf C, Struve K, Marshall L, et al. Slow wave sleep drives inhibition of pituitary-adrenal secretion in humans. J Neuroendocrinol. 1997;9:479–84.PubMedGoogle Scholar
  13. 13.
    Spath-Schwalbe E, Gofferje M, Kern W, et al. Sleep disruption alters nocturnal ACTH and cortisol secretory patterns. Biol Psychiatry. 1991;29:575–84.PubMedGoogle Scholar
  14. 14.
    Prussner JC, Wolf OT, Helhammer DH, et al. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci. 1997;61:2539–49.Google Scholar
  15. 15.
    Brabant G, Prank K, Ranft U, et al. Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman. J Clin Endocrinol Metab. 1990;7:403–9.Google Scholar
  16. 16.
    Parker DC, Rossman LG, Pekary AE, et al. Effect of 64-hour sleep deprivation on the circadian waveform of thyrotropin (TSH): further evidence of sleep-related inhibition of TSH release. J Clin Endocrinol Metab. 1987;64:157–61.PubMedGoogle Scholar
  17. 17.
    Goichot B, Brandenberger G, Saini J, et al. Nocturnal plasma thyrotropin variations are related to slow-wave sleep. J Sleep Res. 1992;1:186–90.PubMedGoogle Scholar
  18. 18.
    Hirschfeld U, Moreno-Reyes R, Akseki E, et al. Progressive elevation of plasma thyrotropin during adaptation to simulated jet lag: effect of treatment with bright light or zolpidem. J Clin Endocrinol Metab. 1996;81:3270–7.PubMedGoogle Scholar
  19. 19.
    Orem J, Keeling J. A compendium of physiology in sleep. In: Orem J, Barnes CD, editors. Physiology in sleep. New York: Academic; 1980. p. 315–35.Google Scholar
  20. 20.
    Spiegel K, Follenius M, Simon C, et al. Prolactin secretion and sleep. Sleep. 1994;17:20–7.PubMedGoogle Scholar
  21. 21.
    Spiegel K, Luthringer R, Follenius M, et al. Temporal relationship between prolactin secretion and slow-wave electroencephalographic activity during sleep. Sleep. 1995;18:543–8.PubMedGoogle Scholar
  22. 22.
    Desir D, Van Cauter E, L’Hermite M, et al. Effects of “jet lag” on hormonal patterns. Demonstration of an intrinsic circadian rhythmicity in plasma prolactin. J Clin Endocrinol Metab. 1982;55:849–57.PubMedGoogle Scholar
  23. 23.
    Roku R, Obal F, Valatx JL, et al. Prolactin and rapid eye movement sleep regulation. Sleep. 1995;18:536–42.Google Scholar
  24. 24.
    Lejeune-Lenain C, Van Cauter E, Desir D, et al. Control of circadian and episodic variations of adrenal androgens secretion in man. J Endocrinol Invest. 1987;10:267–76.PubMedGoogle Scholar
  25. 25.
    Luboshitzky R, Herer P, Levi M, et al. Relationship between rapid eye movement sleep and testosterone secretion in normal men. J Androl. 1999;20:731–7.PubMedGoogle Scholar
  26. 26.
    Luboshitzky R, Zabari Z, Shen-Orr Z, et al. Disruption of nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab. 2001;86:1134–9.PubMedGoogle Scholar
  27. 27.
    Reame N, Sauder SE, Kelch RP, et al. Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin-releasing hormone secretion. J Clin Endocrinol Metab. 1984;59:328–37.PubMedGoogle Scholar
  28. 28.
    Van Cauter E, Polonsky KS, Scheen AJ. Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev. 1997;18:716–38.PubMedGoogle Scholar
  29. 29.
    Boyle PJ, Scott JC, Krentz AJ, et al. Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans. J Clin Invest. 1994;93:529–35.PubMedGoogle Scholar
  30. 30.
    Buchsbaum MS, Gillin JC, Wu J, et al. Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography. Life Sci. 1989;45:1349–56.PubMedGoogle Scholar
  31. 31.
    Maquet P, Dive D, Salmon E, et al. Cerebral glucose utilization during sleep-wake cycle in man determined by positron emission tomography and [18F] 2-fluoro-2-deoxy-D-glucose method. Brain Res. 1990;513:136–43.PubMedGoogle Scholar
  32. 32.
    Plat L, Leproult R, L’Hermite-Baleriaux M, et al. Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans. Am J Physiol Endocrinol Metab. 1996;270:e36–42.Google Scholar
  33. 33.
    Danguir J, Nicolaidis S. Dependence of sleep on nutrients’ availability. Physiol Behav. 1979;22:735–40.PubMedGoogle Scholar
  34. 34.
    Rachtschaffen A, Bergmann BM. Sleep deprivation in the rat by the disk-over-water method. Behav Brain Res. 1995;69:55–63.Google Scholar
  35. 35.
    Saper CB. Staying awake for dinner: hypothalamic integration of sleep, feeding and circadian rhythms. Prog Brain Res. 2006;153:243–52.PubMedGoogle Scholar
  36. 36.
    Adamantidis A, de Lecea L. Sleep and metabolism: shared circuits, new connections. Trend Endocrinol Metabol. 2008;19(10):362–70.Google Scholar
  37. 37.
    Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Rends Neurosci. 2001;24:726–31.Google Scholar
  38. 38.
    Pace-Schott EF, Hobson JA. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci. 2002;3:591–605.PubMedGoogle Scholar
  39. 39.
    Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regul Pept. 2008;149:3–10.PubMedGoogle Scholar
  40. 40.
    Knutson KL, VanCauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci. 2008;1129:287–304.PubMedGoogle Scholar
  41. 41.
    Schoeller DA, Cella LK, Sinha MK, et al. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invesr. 1997;100:1882–7.Google Scholar
  42. 42.
    Simon C, Gronfier C, Schlienger JL, et al. Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endoocrinol Metab. 1998;83:1893–9.Google Scholar
  43. 43.
    Mullington JM, Chan JL, Van Dongen HP, et al. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol. 2003;15:851–4.PubMedGoogle Scholar
  44. 44.
    National Sleep Foundation. “Sleep in America” Poll. Washington, DC: National Sleep Foundation; 2002.Google Scholar
  45. 45.
    Spiegel K, Knutson K, Leproult R, et al. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol. 2005;99:2008–19.PubMedGoogle Scholar
  46. 46.
    Reilly JJ, Armstrong J, Dorosty AR, et al. Early life risk factors for obesity in childhood: cohort study. Br Med J. 2005;330(7504):1357.Google Scholar
  47. 47.
    Sekine M, Yamagami T, Handa K, et al. A dose-response relationship between short sleeping hours and childhood obesity: results of the Toyama Birth Cohort Study. Child Care Health Dev. 2002;28:163–70.PubMedGoogle Scholar
  48. 48.
    Locard E, Mamelle N, Billette A, et al. Risk factors of obesity in a five year old population. Parental versus environmental factors. Int J Obes Relat Metab Disord. 1992;16:721–9.PubMedGoogle Scholar
  49. 49.
    Gupta NK, Mueller WH, Chan W, et al. Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol. 2002;14:762–8.PubMedGoogle Scholar
  50. 50.
    von Kries R, Toschke AM, Wurmser H, et al. Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep—a cross-­sectional study. Int J Obes Relat Metab Disord. 2002;26(5):710–6.Google Scholar
  51. 51.
    Taheri S, Lin L, Austin D, et al. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1:e62.PubMedGoogle Scholar
  52. 52.
    Hasler G, Buysse DJ, Klaghofer R, et al. The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep. 2004;27:661–6.PubMedGoogle Scholar
  53. 53.
    Spiegel K, Tasali E, Penev P, et al. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004;141:846–50.PubMedGoogle Scholar
  54. 54.
    Nedeltcheva AV, Kilkus JM, Imperial J, et al. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009;89:126–33.PubMedGoogle Scholar
  55. 55.
    Chaput JP, Despres JP, Bouchard C, et al. Short sleep duration is associated with reduced leptin levels and increased adiposity: results from the Quebec family study. Obesity. 2007;15:253–61.PubMedGoogle Scholar
  56. 56.
    Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in human. Science. 1999;283:212–4.PubMedGoogle Scholar
  57. 57.
    Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having metabolic syndrome? Results from a population based study of 27485 people. Occup Environ Med. 2001;58: 747–52.PubMedGoogle Scholar
  58. 58.
    Ayas NT, White DP, Al-Delaimy WK, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care. 2003;26:380–4.PubMedGoogle Scholar
  59. 59.
    Nilsson PM, Roost M, Engstrom G, et al. Incidence of diabetes in middle-aged men is related to sleep disturbances. Diabetes Care. 2004;27:2464–9.PubMedGoogle Scholar
  60. 60.
    Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999;354:1435–9.PubMedGoogle Scholar
  61. 61.
    Sakurai T. Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis. Sleep Med Rev. 2005;9:231–41.PubMedGoogle Scholar
  62. 62.
    Samson WK, Taylor MM, Ferguson AV. Non-sleep effects of hypocretin/orexin. Sleep Med Rev. 2005;9:243–52.PubMedGoogle Scholar
  63. 63.
    Lubkin M, Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun. 1998;253:241–5.PubMedGoogle Scholar
  64. 64.
    Williams RH, Alexopoulos H, Jensen LT, et al. Adaptive sugar sensors in hypothalamic feeding circuits. Proc Natl Acad Sci. 2008;105:11975–80.PubMedGoogle Scholar
  65. 65.
    Williams RH, Jensen LT, Verkhratsky A. Control of hypothalamic orexin neurons by acid and CO2. Proc Natl Acad Sci. 2007;104:10685–90.PubMedGoogle Scholar
  66. 66.
    Arnulf I, Lin L, Zhang J, et al. CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency? Sleep. 2006;29:1017–24.PubMedGoogle Scholar
  67. 67.
    Chabas D, Foulon C, Gonzalez J, et al. Eating disorder and metabolism in narcoleptic patients. Sleep. 2007;30:1267–73.PubMedGoogle Scholar
  68. 68.
    Zhang S, Zeitzer JM, Sakurai T, et al. Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol. 2007;581:649–63.PubMedGoogle Scholar
  69. 69.
    Lopez M, Nogueiras R, Tena-Sempere M, et al. Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis. Acta Physiol. 2010;198:325–34.Google Scholar
  70. 70.
    Kukkonen JP, Holmqvist T, Ammoun S, et al. Functions of the orexinergic/hypocretinergic system. Am J Physiol Cell Physiol. 2002;283:C1567–91.PubMedGoogle Scholar
  71. 71.
    Sutcliffe JG, de Lecea L. The hypocretins: setting the arousal threshold. Nat Rev Neurosci. 2002;3: 339–49.PubMedGoogle Scholar
  72. 72.
    Bose M, Olivan B, Laferrere B. Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis I metabolic disease. Curr Opin Endocrinol Diabetes Obes. 2009;16(5):340–6.PubMedGoogle Scholar
  73. 73.
    Peeke PM, Chrousos GP. Hypercortisolism and obesity. Ann NY Acad Sci. 1995;771:665–76.PubMedGoogle Scholar
  74. 74.
    Kyrou I, Chrousos GP, Tigos C. Stress, visceral obesity, and metabolic complications. AN NY Acad Sci. 2006;1083:77–110.Google Scholar
  75. 75.
    Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune mediated inflammation. N Engl J Med. 1995;332:1351–62.PubMedGoogle Scholar
  76. 76.
    Lee SW, Tsou AP, Chan H, et al. Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc Natl Acad Sci. 1988;85: 1204–8.PubMedGoogle Scholar
  77. 77.
    Cronstein BN, Kimmel SC, Levin RI, et al. A mechanism for the antiinflammmatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci. 1992;89:9991–5.PubMedGoogle Scholar
  78. 78.
    Pasquali R, Cantobelli S, Cassimirri F, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab. 1993;77:341–6.PubMedGoogle Scholar
  79. 79.
    Rosmond R, Dallman MF, Bjorntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab. 1998;83:1853–9.PubMedGoogle Scholar
  80. 80.
    Laferrere B, Fried SK, Osborne T, et al. Effect of one morning meal and a bolus of dexamethasone on 24-h variation of serum leptin levels in humans. Obes Res. 2000;8:481–6.PubMedGoogle Scholar
  81. 81.
    Dubuc PU, Wilden NJ. Adrenalectomy reduces but does not reverse obesity in ob/ob mice. Int J Obes. 1986;10:91–8.PubMedGoogle Scholar
  82. 82.
    Spiegel K, Leproult R, L’Hermite-Baleriaux M, et al. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004;89:5762–71.PubMedGoogle Scholar
  83. 83.
    Espelund U, Hansen TK, Hojlund K, et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab. 2005;90:741–6.PubMedGoogle Scholar
  84. 84.
    Panda S, Hogenesch JB, Kay SA. Circadian rhythms from flies to human. Nature. 2002;417:329–35.PubMedGoogle Scholar
  85. 85.
    Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935–41.PubMedGoogle Scholar
  86. 86.
    Davis S, Mirick DK. Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. Cancer Causes Control. 2006;17:539–45.PubMedGoogle Scholar
  87. 87.
    Kondratov RV, Kondratov AA, Gorbacheva VY, et al. Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 2006;20:1868–73.PubMedGoogle Scholar
  88. 88.
    Hurd MW, Ralph MR. The significance of circadian organization for longevity in the golden hamster. J Biol Rhythms. 1998;13:430–6.PubMedGoogle Scholar
  89. 89.
    Karasek M. Melatonin, human aging, and age-related diseases. Exp Gerontol. 2004;39:1723–9.PubMedGoogle Scholar
  90. 90.
    Lee C, Etchegaray JP, Cagampang FR, et al. Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001;107:855–67.PubMedGoogle Scholar
  91. 91.
    Froy O, Chapnik N. Circadian oscillation of innate immunity components in mouse small intestine. Mol Immunol. 2007;4:1964–70.Google Scholar
  92. 92.
    Young ME. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am J Physiol Heart Circ Physiol. 2006;290:H1–16.PubMedGoogle Scholar
  93. 93.
    Froy O. Metabolism and circadian rhythms-implications for obesity. Endocr Rev. 2010;31(1):1–24.PubMedGoogle Scholar
  94. 94.
    La Fleur SE, Kalsbeek A, Wortel J, et al. A sup­rachiasmatic nucleus generated rhythm in basal glucose concentrations. J Neuroendocrinol. 1999;11: 643–52.PubMedGoogle Scholar
  95. 95.
    Ruiter M, La Fleur SE, van Heijningen C, et al. The daily rhythm in plasma glucagon concentrations in rat is modulated by the biological clock and by feeding behavior. Diabetes. 2003;52:1709–15.PubMedGoogle Scholar
  96. 96.
    Ando H, Yanagihara H, Hayashi Y, et al. Rhythmic messenger ribonucleic acid and expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology. 2005;146:5631–6.PubMedGoogle Scholar
  97. 97.
    De Boer SF, Van der Gugen J. Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats. Physiol Behav. 1987;40:323–8.PubMedGoogle Scholar
  98. 98.
    Ahima RS, Prabakaran D, Flier JS. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest. 1998;101: 1020–7.PubMedGoogle Scholar
  99. 99.
    Bodosi B, Gardi J, Haju I, et al. Rhythms of ghrelin, leptin, and sleep in rats: effects of normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol Regul Integr Comp Physiol. 2004;287: R1071–9.PubMedGoogle Scholar
  100. 100.
    Kalra SP, Bagnasco M, Otukonyong EE, et al. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept. 2003;111:1–11.PubMedGoogle Scholar
  101. 101.
    Kalsbeek A, Fliers E, Romijn JA, et al. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology. 2001;142:2677–85.PubMedGoogle Scholar
  102. 102.
    Froy O. The relationship between nutrition and circadian rhythms in mammals. Front Neuroendocrinol. 2007;28:61–71.PubMedGoogle Scholar
  103. 103.
    Green CB, Takahashi JS, Bass J. The meter of metabolism. Cell. 2008;134:728–42.PubMedGoogle Scholar
  104. 104.
    Hirota T, Fukada Y. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoolog Sci. 2004;21:359–68.PubMedGoogle Scholar
  105. 105.
    Ramsey KM, Marcheva B, Kohsaka A, et al. The clockwork of metabolism. Annu Rev Nutr. 2007;27:219–40.PubMedGoogle Scholar
  106. 106.
    La Fleur SE. Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J Neuroendocrinol. 2003;15:315–22.PubMedGoogle Scholar
  107. 107.
    Davidson AJ, Casranoon-Cervantes O, Stephan FK. Daily oscillations in liver function: diurnal vs circadian rhythmicity. Liver Int. 2004;24:179–86.PubMedGoogle Scholar
  108. 108.
    Froy O. Cytochrome p450 and the biological clock in mammals. Curr Drug Metab. 2009;10:104–15.PubMedGoogle Scholar
  109. 109.
    Stephan FK, Davidson AJ. Glucose, but not fat, phase shifts the feeding-entrained circadian clock. Physiol Bahv. 1998;65:277–88.Google Scholar
  110. 110.
    Iwanaga H, Yano M, Miki H, et al. Per2 gene expressions in the suprachiasmatic nucleus and liver differentially respond to nutrition factors. JPEN. 2005;29:157–61.Google Scholar
  111. 111.
    Mohri T, Emoto N, Nonaka H, et al. Alterations of circadian expression of clock genes in Dahl salt-sensitive rats fed a high-salt diet. Hypertension. 2003;42:189–94.PubMedGoogle Scholar
  112. 112.
    Antle MC, Steen NM, Mistlberger RE. Adenosine and caffeine modulate circadian rhythms in the Syrian hamster. Neuroport. 2001;12:2901–5.Google Scholar
  113. 113.
    Langlais PJ, Hall T. Thiamine deficiency-induced disruptions in diurnal rhythm and regulation of body temperature in the rat. Metab Brain Res. 1998;13:225–39.Google Scholar
  114. 114.
    Balsalobre A, Brown SA, Marcacci L, et al. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science. 2000;289:2344–7.PubMedGoogle Scholar
  115. 115.
    Reddy AB, Maywood ES, Karp NA, et al. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology. 2007;45: 1478–88.PubMedGoogle Scholar
  116. 116.
    Fu L, Patel MS, Bradley A, et al. The molecular clock mediates leptin-regulated bone formation. Cell. 2005;122:803–15.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Sleep Disorder Center, Dana Children’s Hospital, Tel Aviv Medical CenterTel AvivIsrael

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