Metabolic Consequences of Sleep Disorders
In parallel with the explosive increase in obesity rates among children, exploration of potential associations between sleep and obesity has been now extensively pursued, particularly in the wake of our increased understanding of sleep and circadian clocks as critical metabolic regulators. In this chapter, I initially examine some of the evidence on such proposed associations. The increase in the prevalence of overweight and obese children is also anticipated to be deleterious to global health outcomes and life expectancy, and among such consequences, it can increase the risk of obstructive sleep apnea, and such issue is therefore critically assessed as well. Since both conditions can be viewed as low-grade inflammatory disorders, coexistence of obesity and sleep apnea could further interact to amplify their putative effects on metabolic regulation.
KeywordsObstructive Sleep Apnea Sleep Apnea Continuous Positive Airway Pressure Obese Child Obstructive Sleep Apnea Syndrome
David Gozal is supported by National Institutes of Health grants HL-65270 and HL-086662.
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