Gastroesophageal Reflux and Sleep-Disordered Breathing
Gastroesophageal reflux (GER) is a common clinical problem in children. Although GER can be physiological in infancy, a significant number of children will develop gastroesophageal reflux disease (GERD), as evidenced by the presence of accompanying esophageal and extra-esophageal symptoms. There are profound physiological changes in the upper gastrointestinal tract function during sleep. In fact, sleep is viewed as a vulnerable state that promotes the presence of GER, and can therefore lead to GERD. Given the proximity of the upper airway to the upper gastrointestinal tract, sleep disordered breathing (SDB) and GERD share bi-directional cause and effect relationships. This chapter describes some of the pertinent mechanisms of GER, the changes in esophageal function that accompany sleep, and the clinical manifestations associated with sleep-related GERD.
KeywordsObstructive Sleep Apnea Continuous Positive Airway Pressure Lower Esophageal Sphincter Reflux Episode Reflux Event
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