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Sleep Problems in Children with Sickle Cell Disease

  • Umakanth KhatwaEmail author
  • Alia Bazzy-Asaad
  • Sanjeev V. Kothare
Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

Sickle cell disease (SCD) is the most prevalent hemoglobinopathy in the USA. It has been reported that children with SCD have an increased risk for sleep problems including sleep-disordered breathing (SDB) compared to the general pediatric population. These children are also at an increased risk for adenotonsillar hypertrophy due to secondary hyperplasia of the lymphoid tissues following splenic infarction and extramedullary hematopoiesis. They are, therefore, more likely to develop upper airway obstruction. Both daytime and nocturnal hypoxemias are common in children with SCD; however, the accuracy of pulse oximetry in measuring oxyhemoglobin saturation has been questioned by several investigators. In this chapter, we attempt to review the prevalence of various sleep problems including SDB in children with SCD and discuss the link between SCD and hypoxemia, SDB, vaso-occlusive crises, stroke, and pulmonary hypertension. We review common sleep problems and their clinical presentation in children with SCD and outline their evaluation and treatment strategies.

Keywords

Obstructive Sleep Apnea Sickle Cell Disease Pulse Oximetry Nocturnal Enuresis Cerebral Blood Flow Velocity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Umakanth Khatwa
    • 1
    Email author
  • Alia Bazzy-Asaad
    • 2
  • Sanjeev V. Kothare
    • 3
    • 4
  1. 1.Division of Respiratory Diseases, Department of MedicineChildren’s Hospital Boston, Harvard Medical SchoolBostonUSA
  2. 2.Department of PediatricsYale University School of MedicineNew HavenUSA
  3. 3.Division of Epilepsy and Clinical Neurophysiology, Department of NeurologyChildren’s Hospital Boston, Harvard Medical SchoolBostonUSA
  4. 4.Center for Pediatric Sleep Disorders, Department of NeurologyChildren’s Hospital Boston, Harvard Medical SchoolBostonUSA

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