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Sleep Problems in Children with Sickle Cell Disease

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Book cover Sleep Disordered Breathing in Children

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Sickle cell disease (SCD) is the most prevalent hemoglobinopathy in the USA. It has been reported that children with SCD have an increased risk for sleep problems including sleep-disordered breathing (SDB) compared to the general pediatric population. These children are also at an increased risk for adenotonsillar hypertrophy due to secondary hyperplasia of the lymphoid tissues following splenic infarction and extramedullary hematopoiesis. They are, therefore, more likely to develop upper airway obstruction. Both daytime and nocturnal hypoxemias are common in children with SCD; however, the accuracy of pulse oximetry in measuring oxyhemoglobin saturation has been questioned by several investigators. In this chapter, we attempt to review the prevalence of various sleep problems including SDB in children with SCD and discuss the link between SCD and hypoxemia, SDB, vaso-occlusive crises, stroke, and pulmonary hypertension. We review common sleep problems and their clinical presentation in children with SCD and outline their evaluation and treatment strategies.

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Authors and Affiliations

  1. Division of Respiratory Diseases, Department of Medicine, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Hunnewell 2, Boston, MA, 02115, USA

    Umakanth Khatwa MD

  2. Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, Fitkin 5, Room 510, New Haven, CT, 06510, USA

    Alia Bazzy-Asaad MD

  3. Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Fegan 9, Boston, MA, 02115, USA

    Sanjeev V. Kothare MD

  4. Center for Pediatric Sleep Disorders, Department of Neurology, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Fegan 9, Boston, MA, 02115, USA

    Sanjeev V. Kothare MD

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  1. Umakanth Khatwa MD
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  2. Alia Bazzy-Asaad MD
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Correspondence to Umakanth Khatwa MD .

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  1. Section of Sleep Medicine, Pritzker School of Medicine, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    Leila Kheirandish-Gozal

  2. Pritzker School of Medicine, Comer Children's Hospital, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    David Gozal

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Khatwa, U., Bazzy-Asaad, A., Kothare, S.V. (2012). Sleep Problems in Children with Sickle Cell Disease. In: Kheirandish-Gozal, L., Gozal, D. (eds) Sleep Disordered Breathing in Children. Respiratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-725-9_24

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