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Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

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Pediatric Neurogastroenterology

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

Disorders of gastrointestinal motility result from abnormal contractions of the smooth muscles of the gastrointestinal tract. This may result in diarrhea and bloating or constipation with or without accompanying abdominal pain. Drugs that act on the gastrointestinal tract may be categorized into three groups: (1) agents that enhance smooth muscle contractions, referred to as prokinetic agents; (2) agents that inhibit contractions, which may be agents that retard normal peristalsis referred to as antimotility agents (opiates and opiate receptor agonists) or agents that reduce abnormally elevated gastrointestinal smooth muscle tone, referred to as antispasmodics (anticholinergics, direct smooth muscle relaxers, and calcium channel blockers); (3) agents that act to promote evacuation of stool, referred to as laxatives. This chapter discusses prokinetics, antimotility agents, and antispasmodics, as well as laxatives commonly used in clinical practice.

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Correspondence to Joseph M. B. Croffie M.D., M.P.H. .

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  1. Sainte-Justine Hospital, Department of Pediatrics, Division of Pediatric Gastroenterology, Université de Montréal, Montreal, H3T 1C5, Québec, Canada

    Christophe Faure

  2. Nationwide Children's Hospital, Division of Pediatric Gastroenterology, The Ohio State University, Columbus, 43205, Ohio, USA

    Carlo Di Lorenzo

  3. Gastroenterology and Neural Development, University College London, Institute of Child Health, Great Ormond Street Hospital for Children, London, WC1N 1EH, United Kingdom

    Nikhil Thapar

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Har, A.F., Croffie, J.M.B. (2013). Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives. In: Faure, C., Di Lorenzo, C., Thapar, N. (eds) Pediatric Neurogastroenterology. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-709-9_41

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  • DOI: https://doi.org/10.1007/978-1-60761-709-9_41

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-708-2

  • Online ISBN: 978-1-60761-709-9

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