Abstract
Functional constipation is common in childhood and is defined by the presence of at least 2 of 6 criteria: stool frequency <3/week, hardness, large size, fecal incontinence, volitional stool withholding, and stool retention. The symptom must be present for 1 month in infants and toddlers and 2 months in children and adolescents. It can be accompanied by fecal incontinence, abdominal or rectal pain, urinary incontinence, urinary tract infections, distress to children and families, and affects all aspects of the child’s development. Organic causes of constipation are ruled out by history and physical examination, and if necessary, by laboratory tests, anorectal manometry, barium enema, and rectal biopsy. Treatment of functional constipation requires a combination of parent and patient education, nutritional intervention, behavioral intervention, pharmacotherapy, close follow-up, and long-term compliance with the treatment regimen. The choice of laxative to achieve 1–2 bowel movements daily is less important than the use of an adequate dose.
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References
van den Berg MM, Benninga MA, DiLorenzo C. Epidemiology of childhood constipation: a systemic review. Am J Gastroenterol. 2006;101:2401–9.
Loening-Baucke V. Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr. 2005;146:359–63.
Issenman RM, Hewson S, Pirhonen D, et al. Are chronic digestive complaints the result of abnormal dietary patterns? Am J Dis Child. 1987;141:679–82.
Yong D, Beattie RM. Normal bowel habit and prevalence of constipation in primary school children. Amb Child Health. 1998;4:277–82.
Loening-Baucke V. Prevalence rates for constipation and faecal and urinary incontinence in children. Arch Dis Child. 2007;92:486–9.
de Araújo Sant’Anna AM, Calçado AC. Constipation in school-aged children at public schools in Rio de Janeiro, Brazil. J Pediatr Gastroenterol Nutr. 1999;29:190–3.
Zaslavsky C, Ávila EL, Araújo MA, et al. Constipação intestinal da infância—um estudo de prevalência. Rev AMRIGS. 1988;32:100–2.
Maffei HVL, Moreira FL, Oliveira WM, et al. Constipação intestinal em escolare. J Pediatr. 1997;73:340–4.
Fontana M, Bianchi C, Cataldo F, et al. Bowel frequency in healthy children. Acta Paediatr Scand. 1989;78:682–4.
Hyman PE, Milla PJ, Benninga MA, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2006;130:1519–26.
Rasquin A, Di Lorenzo C, Forber D, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology. 2006;130:1527–37.
Morris-Yates A, Talley NJ, Boyce PM, et al. Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol. 1998;93:1311–7.
Loening-Baucke V, Pashankar DS. A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia in children with constipation and fecal incontinence. Pediatrics. 2006;118:528–35.
Loening-Baucke V, Swidsinski A. Constipation as cause of acute abdominal pain in children. J Pediatr. 2007;151:666–9.
Loening-Baucke V. Functional constipation is the most frequent cause of functional abdominal pain in children. Open Pediatr Med J. 2008;2:7–10.
Loening-Baucke V. Urinary incontinence and urinary tract infection and their resolution with treatment of chronic constipation of childhood. Pediatrics. 1997;100:228–32.
Loening-Baucke V. Factors determining outcome in children with chronic constipation and faecal. Gut. 1989;30:999–1006.
van Dijk M, Benninga MA, Grootenhuis MA, et al. Prevalence and associated clinical characteristics of behavior problems in constipated children. Pediatrics. 2010;125:e309–17. Assessed March 23, 2010.
Loening-Baucke V, Cruikshank B, Savage C. Evaluation of defecation dynamics and behavior profiles in encopretic children. Pediatrics. 1987;80:672–9.
Youssef N, Langseder A, Verga B, et al. Chronic childhood constipation is associated with impaired quality of life: a case-controlled study. J Pediatr Gastroenterol Nutr. 2005;41:56–60.
Loening-Baucke V. Factors responsible for persistence of childhood constipation. J Pediatr Gastroenterol Nutr. 1987;6:915–22.
Loening-Baucke V. Abnormal defecation dynamics in chronically constipated children with functional fecal incontinence. J Pediatr. 1996;128:336–40.
Wald A, Chandra R, Gabel S, et al. Evaluation of biofeedback in childhood functional fecal incontinence. J Pediatr Gastroenterol Nutr. 1987;6:554–8.
Loening-Baucke V, Krishna R, Pashankar DS. Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers. J Pediatr Gastroenterol Nutr. 2004;39:536–9.
Partin JC, Hamill SK, Fischel JE, et al. Painful defecation and fecal incontinence in children. Pediatrics. 1992;89:1007–9.
Borowitz SM, Cox DJ, Tam A, et al. Precipitants of constipation during early childhood. J Am Board Fam Pract. 2003;16:213–8.
Iacono G, Cavataio F, Montalto G, et al. Intolerance of cow’s milk and chronic constipation in children. N Engl J Med. 1998;339:1100–4.
Shah N, Lindley K, Milla P. Cow’s milk and chronic constipation in children. N Engl J Med. 1999;340:891–2.
Daher S, Tahan S, Solé D, et al. Cow’s milk protein intolerance and chronic constipation in children. Pediatr Allergy Immunol. 2001;12:339–42.
Vanderhoof JA, Perry D, Hanner TL, et al. Allergic constipation: association with infantile milk allergy. Clin Pediatr. 2001;40:399–402.
Turunen S, Karttunen TJ, Kokkonen J. Lymphoid hyperplasia and cow’s milk hypersensitivity in children with chronic constipation. J Pediatr. 2004;145:606–11.
El-Hodhod MA, Younis NT, Zaitoun YA, et al. Cow’s milk allergy related pediatric constipation: appropriate time of milk tolerance. Pediatr Allergy Immunol. 2009;DO1: 10.1111/j.1399-3038.2009.00898.x10.1111/j.1399-3038.2009.00898.xAssessed March 23, 2010
Simeone D, Miele E, Boccia G, et al. Prevalence of atopy in children with chronic constipation. Arch Dis Child. 2008;93:1044–7.
Benninga MA, Voskuijl WP, Taminiau AJM. Childhood constipation: is there new light in the tunnel? J Pediatr Gastroenterol Nutr. 2004;39:448–64.
Michail S, Gendy E, Preud’Homme D, et al. Polyethylene glycol for constipation in children younger than eighteen months old. J Pediatr Gastroenterol Nutr. 2004;39:197–9.
Youssef NN, Peters JM, Henderson W, et al. Dose responses of PEG 3350 for the treatment of childhood fecal impaction. J Pediatr. 2002;141:410–4.
Dupont C, Leluyer B, Amar F, et al. A dose determination study of polyethylene glycol 4000 in constipated children; factors influencing the maintenance dose. J Pediatr Gastroenterol Nutr. 2006;42:178–85.
Candy D, Belsey J. Macrogol (polyethylene glycol) laxatives in children with functional constipation and faecal impaction: a systemic review. Arch Dis Child. 2009;94:156–60.
Candy DC, Edwards D, Geraint M. Treatment of faecal impaction with polyethylene glycol plus electrolytes (PEG + E) followed by a double-blind comparison of PEG + E versus lactulose as maintenance therapy. J Pediatr Gastroenterol Nutr. 2006;43:65–70.
Bekkali NL, van den Berg MM, Dijkgraaf MG, et al. Rectal fecal impaction treatment in childhood constipation: enemas versus high doses oral PEG. Pediatrics. 2009;124:e1108–15. Accessed March 23, 2010.
Harrington L, Schuh S. Complications of Fleet®enema administration and suggested guidelines for use in the pediatric emergency department. Pediatr Emergency Care. 1997;13:225–6.
Roma E, Adamidis D, Nikolara R, et al. Diet and chronic constipation in children: the role of fiber. J Ped Gastroenterol Nutr. 1999;28:169–74.
Morais MB, Vitolo MR, Aquirre ANC, et al. Measurement of low dietary fiber intake as a risk factor for chronic constipation in children. J Ped Gastroenterol Nutr. 1999;29:132–5.
Zaslavsky C, Reverbel da Silveira T, Maguilnik I. Total and segmental colonic transit time with radio-opaque markers in adolescents with functional constipation. J Ped Gastroenterol Nutr. 1998;27:138–42.
Williams CL, Bollella M, Wynder EL. A new recommendation for dietary fiber in childhood. Pediatrics. 1995;96:985–8.
Staiano A, Simeone D, Del Giudice E, et al. Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. J Pediatr. 2000;136:41–5.
Loening-Baucke V, Miele E, Staiano A. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Pediatrics. 2004;113:e259–64. Assessed March 23, 2010.
Castillejo G, Bullo M, Anguera A, et al. A controlled, randomized, double-blind trial to evaluate the effect of supplement of cocoa husk that is rich in fiber on colonic transit in constipated pediatric patients. Pediatrics. 2006;118:641–8.
Kokke FTM, Scholtens PAMJ, et al. A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial. J Pediatr Gastroenterol Nutr. 2008;47:592–7.
Loening-Baucke V. Polyethylene glycol without electrolytes for children with constipation and functional fecal incontinence. J Pediatr Gastroenterol Nutr. 2002;34:372–7.
Pashankar DS, Bishop WP. Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and functional fecal incontinence in children. J Pediatr. 2001;139:428–32.
Nurko S, Youssef NN, Sabri M, et al. PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008;153:254–61.
Pashankar DS, Bishop WP, Loening-Baucke V. Long-term efficacy of polyethylene glycol 3350 for the treatment of chronic constipation in children with and without functional fecal incontinence. Clin Pediatr. 2003;42:815–9.
Pashankar DS, Loening-Baucke V, Bishop WP. Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children. Arch Pediatr Adolesc Med. 2003;157:661–4.
Baker S, Liptak G, Colletti R, et al. Evaluation and treatment of constipation in children: summary of updated recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2006;43:405–7.
Baker SS, Liptak GS, Colletti RB, et al. Constipation in infants and children: evaluation and treatment. J Pediatr Gastroenterol Nutr. 1999;29:612–26.
Müller-Lissner SA, Kamm MA, Scarpignato C, et al. Myths and misconceptions about chronic constipation. Am J Gastroenterol. 2005;100:232–42.
van Ginkel R, Reitsma JB, Büller HA, et al. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003;125:357–63.
van Ginkel R, Bueller HA, Boeckxstaens GE, et al. The effect of anorectal manometry on the outcome of treatment in severe childhood constipation: a randomized, controlled trial. Pediatrics. 2001;108:E9. \.
Nolan TM, Debelle G, Oberklaid F, et al. Randomised trial of laxatives in treatment of childhood functional fecal incontinence. Lancet. 1991;338(8766):523–7.
Nolan T, Catto-Smith T, Coffey C, et al. Randomised controlled trial of biofeedback training in persistent functional fecal incontinence with anismus. Arch Dis Child. 1998;79:131–5.
Thomson MA, Jenkins HR, Bisset WM, et al. Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study. Arch Dis Child. 2008;92:996–1000.
Gremse DA, Hixon J, Crutchfield A. Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children. Clin Pediatr. 2002;41:225–9.
Abrahamian FP, Lloyd-Still JD. Chronic constipation in childhood: a longitudinal study of 186 patients. J Pediatr Gastroenterol Nutr. 1984;3:460–7.
Staiano A, Andreotti MR, Greco L, et al. Long-term follow-up of children with chronic idiopathic constipation. Dig Dis Sci. 1994;39:561–4.
Levine MD, Bakow H. Children with functional fecal incontinence: a study of treatment outcome. Pediatrics. 1976;58:845–52.
Loening-Baucke V. Functional fecal retention with functional fecal incontinence in childhood. J Pediatr Gastroenterol Nutr. 2004;38:79–84.
Pijpers M, Bongers M, Benninga M, et al. Functional constipation in children: a systemic review on prognosis and predictive factors. J Pediatr Gastroenterol Nutr. 2010;50:256–68.
Loening-Baucke V. Constipation in early childhood: patient characteristics, treatment, and longterm follow up. Gut. 1993;34:1400–4.
Loening-Baucke V. Biofeedback treatment for chronic constipation and functional fecal incontinence in childhood: long-term outcome. Pediatrics. 1995;96:105–10.
Procter E, Loader P. A 6 year follow-up study of chronic constipation and soiling in a specialist paediatric service. Childcare Health Dev. 2003;29:203–9.
Michaud L, Lamblin M-D, Mairesse S, et al. Outcome of functional constipation in childhood: a 10-year follow-up study. Clin Pediatr. 2009;48:26–31.
Zoppi G, Cinquetti M, Luciano A, et al. The intestinal ecosystem in functional constipation. Acta Paediatr. 1998;87:836–41.
Banaszkiewicz A, Szajewska H. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. J Pediatr. 2005;146:364–9.
Bu LN, Chang MH, Ni YH, et al. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatr Int. 2007;49:485–90.
Loening-Baucke V. Modulation of abnormal defecation dynamics by biofeedback treatment in chronically constipated children with functional fecal incontinence. J Pediatr. 1990;116:214–22.
van der Plas RN, Benninga MA, Büller HA, et al. Biofeedback training in treatment of childhood constipation: A randomised controlled study. Lancet. 1996;348(9030):776–80.
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Loening-Baucke, V., Swidsinski, A. (2013). Constipation. In: Faure, C., Di Lorenzo, C., Thapar, N. (eds) Pediatric Neurogastroenterology. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-709-9_39
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