Skip to main content
SpringerLink
Log in
Book cover

Pediatric Neurogastroenterology pp 257–270Cite as

Chronic Intestinal Pseudo-Obstruction

  • Chapter
  • First Online:

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Chronic intestinal pseudo-obstruction (CIPO) is a diagnosis which encompasses a heterogeneous group of rare disorders involving intrinsic enteric nerves, muscles, and/or connective tissues which impairs gastrointestinal motility. CIPO is in a general sense the motility disorder with the greatest morbidity and mortality per patient. One third of those with congenital CIPO require total parenteral nutrition (TPN), and it is those infants and children who are at risk for serious complications such as sepsis, thrombo-embolic disease, TPN-associated liver disease, and gallstones.

Factors relating to better outcomes include maintaining good nutrition, avoiding acute intercurrent illness, enteral nutrition support, and avoiding surgery. Clinicians strive first to support normal growth and development. Second, clinicians strive to utilize the gastrointestinal tract for nutrition support rather than using TPN. Treatment of abdominal distension, abdominal pain, nausea and vomiting often require decompression of dilated bowel as a first step. Decompression may be accomplished by gastrostomy or ileostomy. Improvements in management may include bowel transplantation or stem cell therapy to replace diseased nerves or muscle.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   249.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Faure C, Goulet O, Ategbo S, et al. Chronic intestinal pseudoobstruction syndrome: clinical analysis, outcome, and prognosis in 105 children. French-Speaking Group of Pediatric Gastroenterology. Dig Dis Sci. 1999;44:953–9.

    Article  PubMed  CAS  Google Scholar 

  2. Granata C, Puri P. Megacystis-microcolon-hypoperistalsis syndrome. J Pediatr Gastroenterol Nutr. 1997;25:12–9.

    Article  PubMed  CAS  Google Scholar 

  3. Heneyke S, Smith VV, Spitz L, et al. Chronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients. Arch Dis Child. 1999;81:21–7.

    Article  PubMed  CAS  Google Scholar 

  4. Krishnamurthy S, Heng Y, Schuffler MD. Chronic intestinal pseudo-obstruction in infants and children caused by diverse abnormalities of the myenteric plexus. Gastroenterology. 1993;104:1398–408.

    PubMed  CAS  Google Scholar 

  5. Schuffler MD. Visceral myopathy of the gastrointestinal and genitourinary tracts in infants. Gastroenterology. 1988;94:892–8.

    PubMed  CAS  Google Scholar 

  6. Vargas JH, Sachs P, Ament ME. Chronic intestinal pseudo-obstruction syndrome in pediatrics: results of a national survey by members of the North American Society of Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1988;7:323–32.

    Article  PubMed  CAS  Google Scholar 

  7. Connor FL, Di Lorenzo C. Chronic intestinal pseudo-obstruction: assessment and management. Gastroenterology. 2006;130(2 Suppl 1):S29–36.

    Article  PubMed  CAS  Google Scholar 

  8. Uc A, Vasiliauskas E, Piccoli D, et al. Chronic intestinal pseudo-obstruction associated with fetal alcohol syndrome. Dig Dis Sci. 1997;42:1163–7.

    Article  PubMed  CAS  Google Scholar 

  9. Golzarian J, Scott Jr HW, Richards WO. Hypermagnesemia-induced paralytic ileus. Dig Dis Sci. 1994;39:1138–42.

    Article  PubMed  CAS  Google Scholar 

  10. Weaver LT, Rosenthal SR, Gladstone W, et al. Carnitine deficiency: a possible cause of gastrointestinal dysmotility. Acta Paediatr. 1992;81:79–81.

    Article  PubMed  CAS  Google Scholar 

  11. Horn T, Svendsen LB, Nielsen R. Brown-bowel syndrome. Review of the literature and presentation of cases. Scand J Gastroenterol. 1990;25:66–72.

    Article  PubMed  CAS  Google Scholar 

  12. Ward HC, Leake J, Milla PJ, et al. Brown bowel syndrome: a late complication of intestinal atresia. J Pediatr Surg. 1992;27:1593–5.

    Article  PubMed  CAS  Google Scholar 

  13. Sonsino E, Movy R, Foucaud P, et al. Intestinal pseudo-obstruction related to cytomegalovirus infection of the myenteric plexus. N Engl J Med. 1984;311:196–7.

    PubMed  CAS  Google Scholar 

  14. Besnard M, Faure C, Fromont-Hankard G, et al. Intestinal pseudo-obstruction and acute pandysautonomia associated with Epstein-Barr virus infection. Am J Gastroenterol. 2000;95:280–4.

    Article  PubMed  CAS  Google Scholar 

  15. Vassallo M, Camilleri M, Caron BL, et al. Gastrointestinal motor dysfunction in acquired selective cholinergic dysautonomia associated with infectious mononucleosis. Gastroenterology. 1991;100:252–8.

    PubMed  CAS  Google Scholar 

  16. Debinski HS, Ahmed S, Milla PJ, et al. Electrogastrography in chronic intestinal pseudoobstruction. Dig Dis Sci. 1996;41:1292–7.

    Article  PubMed  CAS  Google Scholar 

  17. Sigurdsson L, Flores A, Putnam PE, et al. Postviral gastroparesis: presentation, treatment, and outcome. J Pediatr Gastroenterol Nutr. 1997;131:751–4.

    CAS  Google Scholar 

  18. Chatila R, Kapadia CR. Intestinal pseudoobstruction in acute Lyme disease: a case report. Am J Gastroenterol. 1998;93:1179–80.

    Article  PubMed  CAS  Google Scholar 

  19. Ortiz-Alvarez O, Cabral D, Prendiville JS, et al. Intestinal pseudo-obstruction as an initial ­presentation of systemic sclerosis in two children. Br J Rheumatol. 1997;36:280–4.

    Article  PubMed  CAS  Google Scholar 

  20. Perlemuter G, Chaussade S, Wechsler B, et al. Chronic intestinal pseudo-obstruction in systemic lupus erythematosus. Gut. 1998;43:117–22.

    Article  PubMed  CAS  Google Scholar 

  21. Ginies JL, Francois H, Joseph MG, et al. A curable cause of chronic idiopathic intestinal pseudo-obstruction in children: idiopathic myositis of the small intestine. J Pediatr Gastroenterol Nutr. 1996;23:426–9.

    Article  PubMed  CAS  Google Scholar 

  22. Ruuska TH, Karikoski R, Smith VV, et al. Acquired myopathic intestinal pseudo-obstruction may be due to autoimmune enteric leiomyositis. Gastroenterology. 2002;122:1133–9.

    PubMed  Google Scholar 

  23. De Giorgio R, Barbara G, Stanghellini V, et al. Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases. Am J Gastroenterol. 2002;97:2454–9.

    Article  PubMed  Google Scholar 

  24. Smith VV, Gregson N, Foggensteinor L, et al. Acquired intestinal aganglionosis and circulating autoantibodies without neoplastic or other neuronal involvement. Gastroenterology. 1997;112:1366–71.

    Article  PubMed  CAS  Google Scholar 

  25. Burns TM, Lawn ND, Low PA, et al. Adynamic ileus in severe Guillain-Barre syndrome. Muscle Nerve. 2001;24:963–5.

    Article  PubMed  CAS  Google Scholar 

  26. Gohil A, Croffie JM, Fitzgerald JF, et al. Reversible intestinal pseudoobstruction associated with neural crest tumors. J Pediatr Gastroenterol Nutr. 2001;33:86–8.

    Article  PubMed  CAS  Google Scholar 

  27. Salazar A, Naik A, Rolston DD. Intestinal pseudoobstruction as a presenting feature of a pheochromocytoma. J Clin Gastroenterol. 2001;33:253–4.

    Article  PubMed  CAS  Google Scholar 

  28. Anderson NE, Hutchinson DO, Nicholson GJ, et al. Intestinal pseudo-obstruction, myasthenia gravis, and thymoma. Neurology. 1996;47:985–7.

    Article  PubMed  CAS  Google Scholar 

  29. Bodensteiner JB, Grunow JE. Gastroparesis in neonatal myotonic dystrophy. Muscle Nerve. 1984;7:486–7.

    Article  PubMed  CAS  Google Scholar 

  30. Bruinenberg JF, Rieu PN, Gabreels FM, et al. Intestinal pseudo-obstruction syndrome in a child with myotonic dystrophy. Acta Paediatr. 1996;85:121–3.

    Article  PubMed  CAS  Google Scholar 

  31. Leon SH, Schuffler MD, Kettler M, et al. Chronic intestinal pseudoobstruction as a complication of Duchenne’s muscular dystrophy. Gastroenterology. 1986;90:455–9.

    PubMed  CAS  Google Scholar 

  32. Dalakas MC, Park KY, Semino-Mora C, et al. Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene. N Engl J Med. 2000;342:770–80.

    Article  PubMed  CAS  Google Scholar 

  33. Chinnery PF, Jones S, Sviland L, et al. Mitochondrial enteropathy: the primary pathology may not be within the gastrointestinal tract. Gut. 2001;48:121–4.

    Article  PubMed  CAS  Google Scholar 

  34. Haftel LT, Lev D, Barash V, et al. Familial mitochondrial intestinal pseudo-obstruction and neurogenic bladder. J Child Neurol. 2000;15:386–9.

    Article  PubMed  CAS  Google Scholar 

  35. Nishino I, Spinazzola A, Papadimitriou A, et al. Mitochondrial neurogastrointestinal encephalomyopathy: an autosomal recessive disorder due to thymidine phosphorylase mutations. Ann Neurol. 2000;47:792–800.

    Article  PubMed  CAS  Google Scholar 

  36. Axelrod FB, Gouge TH, Ginsburg HB, et al. Fundoplication and gastrostomy in familial dysautonomia. J Pediatr Gastroenterol Nutr. 1991;118:388–94.

    CAS  Google Scholar 

  37. Inamdar S, Easton LB, Lester G. Acquired postganglionic cholinergic dysautonomia: case report and review of the literature. Pediatrics. 1982;70:976–8.

    PubMed  CAS  Google Scholar 

  38. Eck SL, Morse JH, Janssen DA, et al. Angioedema presenting as chronic gastrointestinal symptoms. Am J Gastroenterol. 1993;88:436–9.

    PubMed  CAS  Google Scholar 

  39. Perino LE, Schuffler MD, Mehta SJ, et al. Radiation-induced intestinal pseudoobstruction. Gastroenterology. 1986;91:994–8.

    PubMed  CAS  Google Scholar 

  40. Fang SB, Lee HC, Huang FY, et al. Intestinal pseudo-obstruction followed by major clinical features of Kawasaki disease: report of one case. Acta Paediatr Taiwan. 2001;42:111–4.

    PubMed  CAS  Google Scholar 

  41. Mayer EA, Schuffler MD, Rotter JI, et al. Familial visceral neuropathy with autosomal dominant transmission. Gastroenterology. 1986;91:1528–35.

    PubMed  CAS  Google Scholar 

  42. Roy AD, Bharucha H, Nevin NC, et al. Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. Clin Genet. 1980;18:291–7.

    Article  PubMed  CAS  Google Scholar 

  43. Faulk DL, Anuras S, Gardner D. A familial visceral myopathy. Ann Intern Med. 1987;89:600–6.

    Google Scholar 

  44. Haltia M, Somer H, Palo J, et al. Neuronal intranuclear inclusion disease in identical twins. Ann Neurol. 1984;15:316–21.

    Article  PubMed  CAS  Google Scholar 

  45. Patel H, Norman MG, Perry TL, et al. Multiple system atrophy with neuronal intranuclear hyaline inclusions. Report of a case and review of the literature. J Neurol Sci. 1985;67:57–65.

    Article  PubMed  CAS  Google Scholar 

  46. Schuffler MD, Bird TD, Sumi SM, et al. A familial neuronal disease presenting as intestinal pseudo-obstruction. Gastroenterology. 1978;75:889–98.

    PubMed  CAS  Google Scholar 

  47. Schuffler MD, Lowe MC, Bill AH. Studies of idiopathic intestinal pseudo-obstruction. I. Hereditary hollow visceral myopathy: clinical and pathological studies. Gastroenterology. 1977;73:327–8.

    PubMed  CAS  Google Scholar 

  48. Schuffler MD, Pope CE. Studies of idiopathic intestinal pseudo-obstruction. II. Hereditary hollow visceral myopathy: family studies. Gastroenterology. 1977;73:339–44.

    PubMed  CAS  Google Scholar 

  49. Anuras S, Mitros FA, Nowak TV, et al. A familial visceral myopathy with external ophthalmoplegia and autosomal recessive transmission. Gastroenterology. 1983;84:346–53.

    PubMed  CAS  Google Scholar 

  50. Ionasescu V, Thompson SH, Ionasescu R, et al. Inherited ophthalmoplegia with intestinal pseudo-obstruction. J Neurol Sci. 1983;59:215–28.

    Article  PubMed  CAS  Google Scholar 

  51. Auricchio A, Brancolini V, Casari G, et al. The locus for a novel syndromatic form of neuronal intestinal pseudo-obstruction maps to Xq28. Am J Hum Genet. 1996;58:743–8.

    PubMed  CAS  Google Scholar 

  52. Van Goethem G, Schwartz M, Löfgren A, et al. Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy. Eur J Hum Genet. 2003;11:547–9.

    Article  PubMed  CAS  Google Scholar 

  53. Miele E, Tozzi A, Staiano A, et al. Persistence of abnormal gastrointestinal motility after operation for Hirschsprung’s disease. Am J Gastroenterol. 2000;95(5):1226–30.

    Article  PubMed  CAS  Google Scholar 

  54. Staiano A, Corraziari E, Andriotti MR, et al. Upper gastrointestinal tract motility in children with progressive muscular dystrophy. J Pediatr Gastroenterol Nutr. 1992;121:720–4.

    CAS  Google Scholar 

  55. Selgrad M, De Giorgio R, Fini L, et al. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009;58:25–32.

    Article  PubMed  CAS  Google Scholar 

  56. Cucchiara S, Bassotti G, Castellucci G, et al. Upper gastrointestinal motor abnormalities in children with celiac disease. J Pediatr Gastroenterol Nutr. 1995;21:435–42.

    Article  PubMed  CAS  Google Scholar 

  57. Ginies JL, Francois H, Joseph MG, et al. A curable cause of chronic idiopathic intestinal pseudo-obstruction in children: idiopathic myositis of the small intestine. J Pediatr Gastroenterol Nutr. 1996;23:426–9.

    Article  PubMed  CAS  Google Scholar 

  58. Krishnamurthy S, Schuffler MD. Pathology of neuromuscular disorders of the small intestine and colon. Gastroenterology. 1987;93:610–39.

    PubMed  CAS  Google Scholar 

  59. Streutker CJ, Huizinga JD, Campbell F, et al. Loss of CD117 (c-kit)- and CD34-positive ICC and ­associated CD34-positive fibroblasts defines a subpopulation of chronic intestinal pseudo-obstruction. Am J Surg Pathol. 2003;27(2):228–35.

    Article  PubMed  CAS  Google Scholar 

  60. Knowles CH, De Giorgio R, Kapur RP, et al. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol. 2009;118:271–301.

    Article  PubMed  Google Scholar 

  61. Knowles CH, De Giorgio R, Kapur RP, et al. The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut. 2010;59:882–7.

    Article  PubMed  Google Scholar 

  62. Knowles CH, Farrugia G. Gastrointestinal neuromuscular pathology in chronic constipation. Best Pract Res Clin Gastroenterol. 2011;25(1):43–57.

    Article  PubMed  Google Scholar 

  63. Schuffler MD, Jonak Z. Chronic idiopathic intestinal pseudo-obstruction caused by a degenerative disorder of the myenteric plexus: the use of Smith’s method to define the neuropathology. Gastroenterology. 1982;82:476–86.

    PubMed  CAS  Google Scholar 

  64. Smith B. The neuropathology of the alimentary tract. London: Edward Arnold; 1972.

    Google Scholar 

  65. Schofield ED, Yunis EJ. Intestinal neuronal dysplasia. J Pediatr Gastroenterol Nutr. 1991;12:182–9.

    Article  PubMed  CAS  Google Scholar 

  66. Cord-Udy CL, Smith VV, Ahmed S, et al. An evaluation of the role of suction rectal biopsy in the diagnosis of intestinal neuronal dysplasia. J Pediatr Gastroenterol Nutr. 1997;24:1–6.

    Article  PubMed  CAS  Google Scholar 

  67. Hyman PE, Bursch B, Zeltzer L. Discriminating chronic intestinal pseudo-obstruction from pediatric condition falsification in toddlers. Child Maltreat. 2002;7(2):132–7.

    Article  PubMed  Google Scholar 

  68. Kosmach B, Tarbell S, Reyes J, et al. “Munchausen by proxy” syndrome in a small bowel transplant recipient. Transplant Proc. 1996;28:2790–1.

    PubMed  CAS  Google Scholar 

  69. Hyman PE, Bursch B, Sood M, et al. Visceral pain-associated disability syndrome: a descriptive analysis. J Pediatr Gastroenterol Nutr. 2002;35:663–8.

    Article  PubMed  Google Scholar 

  70. Boige N, Faure C, Cargill G, Mashako LM, Cordeiro-Ferreira G, Viarme F, Cezard JP, Navarro J. Manometrical evaluation in visceral neuropathies in children. J Pediatr Gastroenterol Nutr. 1994;19:71–7.

    Article  PubMed  CAS  Google Scholar 

  71. Schuffler MD, Pope II CE. Esophageal motor dysfunction in idiopathic intestinal pseudoobstruction. Gastroenterology. 1976;70:677–82.

    PubMed  CAS  Google Scholar 

  72. Camilleri M. Jejunal manometry in distal subacute mechanical obstruction: significance of prolonged simultaneous contractions. Gut. 1989;30:468–75.

    Article  PubMed  CAS  Google Scholar 

  73. Summers RW, Anuras S, Green J. Jejunal manometry patterns in health, partial intestinal obstruction, and pseudo-obstruction. Gastroenterology. 1983;85:1301–6.

    PubMed  CAS  Google Scholar 

  74. Fell JME, Smith VV, Milla PJ. Infantile chronic idiopathic intestinal pseudo-obstruction: the role of small intestinal manometry as a diagnostic tool and prognostic indicator. Gut. 1996;39:306–11.

    Article  PubMed  CAS  Google Scholar 

  75. Hyman PE, DiLorenzo C, McAdams L, et al. Predicting the clinical response to cisapride in children with chronic intestinal pseudo-obstruction. Am J Gastroenterol. 1993;88:832–6.

    PubMed  CAS  Google Scholar 

  76. Tomomasa T, DiLorenzo C, Morikawa A, et al. Analysis of fasting antroduodenal manometry in children. Dig Dis Sci. 1996;41:195–203.

    Article  Google Scholar 

  77. Tomomasa T, Itoh Z, Koizumi T, Kitamura T, Suzuki N, Matsuyama S, Kuroume T. Manometric study on the intestinal motility in a case of megacystis-microcolon-intestinal hypoperistalsis syndrome. J Pediatr Gastroenterol Nutr. 1985;4:307–10.

    Article  PubMed  CAS  Google Scholar 

  78. Cucchiara S, Borrelli O, Salvia G, Iula VD, Fecarotta S, Gaudiello G, Boccia G, Annese V. A normal gastrointestinal motility excludes chronic intestinal pseudoobstruction in children. Dig Dis Sci. 2000;45:258–64.

    Article  PubMed  CAS  Google Scholar 

  79. Di Lorenzo C, Flores AF, Reddy SN, et al. Colonic manometry in children with chronic intestinal pseudo-obstruction. Gut. 1993;34:803–7.

    Article  PubMed  Google Scholar 

  80. Devane SP, Ravelli AM, Bisset WM, et al. Gastric antral dysrhythmias in children with chronic idiopathic intestinal pseudo-obstruction. Gut. 1992;33:1477–81.

    Article  PubMed  CAS  Google Scholar 

  81. Dahms BB, Halpin Jr TC. Serial liver biopsies in parenteral nutrition-associated cholestasis of early infancy. Gastroenterology. 1981;81:136–44.

    PubMed  CAS  Google Scholar 

  82. Roslyn JJ, Berquist WE, Pitt HA, et al. Increased risk of gallstones in children receiving total parenteral nutrition. Pediatrics. 1993;71:784–9.

    Google Scholar 

  83. Di Lorenzo C, Flores A, Hyman PE. Intestinal motility and jejunal feeding in children with chronic intestinal pseudo-obstruction. Gastroenterology. 1995;108:1379–85.

    Article  PubMed  Google Scholar 

  84. Di Lorenzo C, Reddy SN, Villanueva-Meyer J, et al. Cisapride in children with chronic intestinal pseudo-obstruction: an acute, double-blind crossover placebo controlled trial. Gastroenterology. 1991;101:1564–70.

    PubMed  Google Scholar 

  85. Di Lorenzo C, Flores AF, Tomomasa T, et al. Effect of erythromycin on antroduodenal motility in children with chronic functional gastrointestinal symptoms. Dig Dis Sci. 1994;39:1399–404.

    Article  PubMed  Google Scholar 

  86. Dranove J, Horn D, Reddy SN, et al. Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry. J Pediatr Surg. 2010;45:777–83.

    Article  PubMed  Google Scholar 

  87. Di Lorenzo C, Lucanto C, Flores AF, et al. Effect of octreotide on gastrointestinal motility in children with functional gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 1998;27(5):508–12.

    Article  PubMed  Google Scholar 

  88. Gomez R, Fernandez S, Aspiroz A, et al. Effect of amoxicillin-clavulanate on gastrointestinal motility in children. J Pediatr Gastroenterol Nutr. 2012;54(6):780–4.

    Article  PubMed  CAS  Google Scholar 

  89. Hyman PE, Garvey TQ, Abrams CE. Tolerance to intravenous ranitidine. J Pediatr Gastroenterol Nutr. 1987;110:794–6.

    CAS  Google Scholar 

  90. Youssef NN, Barksdale Jr E, Griffiths JM, et al. Management of intractable constipation with antegrade enemas in neurologically intact children. J Pediatr Gastroenterol Nutr. 2002;34:402–5.

    Article  PubMed  Google Scholar 

  91. Rosner H, Rubin L, Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain. 1996;12:56–8.

    Article  PubMed  CAS  Google Scholar 

  92. Teitelbaum JE, Berde CB, Nurko S, Buonomo C, Perez-Atayde AR, Fox VL. Diagnosis and management of MNGIE syndrome in children: case report and review of the literature. J Pediatr Gastroenterol Nutr. 2002;35:377–83.

    Article  PubMed  CAS  Google Scholar 

  93. Devulder J, De Laat M, Rolly G. Stellate ganglion block alleviates pseudo-obstruction symptoms followed by episodes of hypermetropia: case report. Reg Anesth. 1997;22:284–6.

    Article  PubMed  CAS  Google Scholar 

  94. Khelif K, Scaillon M, Govaerts MJM, Vanderwinden JM, De Laet MH. Bilateral thoracoscopic splanchnicectomy in chronic intestinal pseudo-obstruction: report of two paediatric cases. Gut. 2006;55:293–4.

    Article  PubMed  CAS  Google Scholar 

  95. Pitt HA, Mann LL, Berquist WE, et al. Chronic intestinal pseudo-obstruction: management with total parenteral nutrition and a venting enterostomy. Arch Surg. 1985;120:614–8.

    Article  PubMed  CAS  Google Scholar 

  96. Michaud L, Guimber D, Carpentier B, Sfeir R, Lambilliotte A, Mazingue F, Gottrand F, Turck D. Gastrostomy as a decompression technique in children with chronic gastrointestinal obstruction. J Pediatr Gastroenterol Nutr. 2001;32:82–5.

    Article  PubMed  CAS  Google Scholar 

  97. Di Lorenzo C, Flores A, Hyman PE. Intestinal motility in symptomatic children with fundoplication. J Pediatr Gastroenterol Nutr. 1991;12:169–73.

    Article  PubMed  Google Scholar 

  98. Ordein J, DiLorenzo C, Flores A, et al. Diversion colitis in children with pseudo-obstruction. Am J Gastroenterol. 1992;87:88–90.

    PubMed  CAS  Google Scholar 

  99. Sigurdsson L, Reyes J, Kocoshis SA, et al. Intestinal transplantation in children with chronic intestinal pseudo-obstruction. Gut. 1999;45:570–4.

    Article  PubMed  CAS  Google Scholar 

  100. Lin Z, Sarosiek I, Forster J, et al. Two-channel gastric pacing in patients with diabetic gastroparesis. Neurogastroenterol Motil. 2011;23(10):912–e396.

    Article  PubMed  Google Scholar 

  101. Mughal MM, Irving MH. Treatment of end stage chronic intestinal pseudo-obstruction by subtotal enterectomy and home parenteral nutrition. Gut. 1988;29(11):1613–7.

    Article  PubMed  CAS  Google Scholar 

  102. Nayyar N, Mazariegos G, Ranganathan S, et al. Pediatric small bowel transplantation. Semin Pediatr Surg. 2010;19(1):68–77.

    Article  PubMed  Google Scholar 

  103. Mousa H, Hyman PE, Cocjin J, et al. Long term outcome of congenital intestinal pseudo-obstruction. Dig Dis Sci. 2002;47:2298–305.

    Article  PubMed  Google Scholar 

  104. Schwankovsky L, Mousa H, Rowhani A, et al. Quality of life outcomes in congenital chronic intestinal pseudo-obstruction. Dig Dis Sci. 2002;47:1965–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastroenterology Division, Children’s Hospital, Louisiana State University, 200 Henry Clay Ave, New Orleans, LA, 70118, USA

    Paul E. Hyman M.D.

  2. Gastroenterology Unit, Division of Neurogastroenterology and Motility, University College London, Institute of Child Health, London, UK

    Nikhil Thapar B.Sc.(hon), B.M.(hon), M.R.C.P., M.R.C.P.C.H., Ph.D.

  3. Department of Paediatric Gastroenterology, Great Ormond Street Hospital for Children, London, UK

    Nikhil Thapar B.Sc.(hon), B.M.(hon), M.R.C.P., M.R.C.P.C.H., Ph.D.

Authors
  1. Paul E. Hyman M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nikhil Thapar B.Sc.(hon), B.M.(hon), M.R.C.P., M.R.C.P.C.H., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paul E. Hyman M.D. .

Editor information

Editors and Affiliations

  1. Sainte-Justine Hospital, Department of Pediatrics, Division of Pediatric Gastroenterology, Université de Montréal, Montreal, H3T 1C5, Québec, Canada

    Christophe Faure

  2. Nationwide Children's Hospital, Division of Pediatric Gastroenterology, The Ohio State University, Columbus, 43205, Ohio, USA

    Carlo Di Lorenzo

  3. Gastroenterology and Neural Development, University College London, Institute of Child Health, Great Ormond Street Hospital for Children, London, WC1N 1EH, United Kingdom

    Nikhil Thapar

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hyman, P.E., Thapar, N. (2013). Chronic Intestinal Pseudo-Obstruction. In: Faure, C., Di Lorenzo, C., Thapar, N. (eds) Pediatric Neurogastroenterology. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-709-9_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-709-9_22

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-708-2

  • Online ISBN: 978-1-60761-709-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation