Skip to main content

Cognitive Function

  • Chapter
  • First Online:
  • 2301 Accesses

Part of the book series: Respiratory Medicine ((RM))

Abstract

Chronic obstructive pulmonary disease (COPD), as previously discussed in other chapters, is a chronic disease with systemic manifestations affecting individuals impairment in the lungs. The brain and associated cognitive functions are not exempt from the systemic effects of COPD. Cognitive function refers to several cognitive processes that influence an individual’s ability to learn, remember, judge, decide, and plan. Deterioration of cognitive processes is known to be associated with age, but has not been as widely appreciated in chronic illnesses such as COPD. Alterations in cognitive function due to COPD are entwined with normal cognitive decline resulting from normal aging. This chapter reviews normal cognitive aging, cognitive function in COPD, common screening techniques used to detect cognitive changes, and treatment approaches.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Grady CL. Age-related differences in face processing: a meta-analysis of three functional ­neuroimaging experiments. Can J Exp Psychol. 2002;56(3):208–20.

    PubMed  Google Scholar 

  2. Madden DJ et al. Aging and recognition memory: changes in regional cerebral blood flow associated with components of reaction time distributions. J Cogn Neurosci. 1999;11(5):511–20.

    Article  PubMed  CAS  Google Scholar 

  3. Grady CL et al. The effects of age on the neural correlates of episodic encoding. Cereb Cortex. 1999;9(8):805–14.

    Article  PubMed  CAS  Google Scholar 

  4. Drag LL, Bieliauskas LA. Contemporary review 2009: cognitive aging. J Geriatr Psychiatry Neurol. 2010;23(2):75–93.

    Article  PubMed  Google Scholar 

  5. Kray J, Lindenberger U. Adult age differences in task switching. Psychol Aging. 2000;15(1):126–47.

    Article  PubMed  CAS  Google Scholar 

  6. Mayr U, Kliegl R. Task-set switching and long-term memory retrieval. J Exp Psychol Learn Mem Cogn. 2000;26(5):1124–40.

    Article  PubMed  CAS  Google Scholar 

  7. Mortensen L, Meyer AS, Humphreys GW. Age-related effects on speech production: a review. Lang Cogn Process. 2006;21:238–90.

    Article  Google Scholar 

  8. Coffey CE et al. Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation. J Neuropsychiatry Clin Neurosci. 2001;13(4):471–85.

    Article  PubMed  CAS  Google Scholar 

  9. Bastin C, Van der Linden M. The contribution of recollection and familiarity to recognition memory: a study of the effects of test format and aging. Neuropsychology. 2003;17(1):14–24.

    Article  PubMed  Google Scholar 

  10. Grady CL et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci. 1994;14(3 Pt 2):1450–62.

    PubMed  CAS  Google Scholar 

  11. Almendros I et al. Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea. Respir Res. 2010;11:3.

    Article  PubMed  Google Scholar 

  12. Borson S et al. Modeling the impact of COPD on the brain. Int J Chron Obstruct Pulmon Dis. 2008;3(3):429–34.

    PubMed  Google Scholar 

  13. Duong T, Acton PJ, Johnson RA. The in vitro neuronal toxicity of pentraxins associated with Alzheimer’s disease brain lesions. Brain Res. 1998;813(2):303–12.

    Article  PubMed  CAS  Google Scholar 

  14. Engelhart MJ et al. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch Neurol. 2004;61(5):668–72.

    Article  PubMed  Google Scholar 

  15. Kuo HK et al. Effect of blood pressure and diabetes mellitus on cognitive and physical functions in older adults: a longitudinal analysis of the advanced cognitive training for independent and vital elderly cohort. J Am Geriatr Soc. 2005;53(7):1154–61.

    Article  PubMed  Google Scholar 

  16. Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J. 2010;35(4):913–22.

    Article  PubMed  CAS  Google Scholar 

  17. Grant I et al. Neuropsychologic findings in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med. 1982;142(8):1470–6.

    Article  PubMed  CAS  Google Scholar 

  18. Grant I et al. Progressive neuropsychologic impairment and hypoxemia. Relationship in chronic obstructive pulmonary disease. Arch Gen Psychiatry. 1987;44(11):999–1006.

    PubMed  CAS  Google Scholar 

  19. Mason RJ et al. Murray and Nadel’s textbook of respiratory medicine. 5th ed. Philadelphia: Sanders Elsiver; 2010.

    Google Scholar 

  20. Heaton RK et al. Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med. 1983;143(10):1941–7.

    Article  PubMed  CAS  Google Scholar 

  21. Prigatano GP et al. Neuropsychological test performance in mildly hypoxemic patients with chronic obstructive pulmonary disease. J Consult Clin Psychol. 1983;51(1):108–16.

    Article  PubMed  CAS  Google Scholar 

  22. Strauss E, Sherman EMS, Spreen O. A compedium of neuropsychological test: administration, norms, and commentary. 3rd ed. New York: Oxford University Press; 2006.

    Google Scholar 

  23. Fix AJ et al. Neuropsychological deficits among patients with chronic obstructive pulmonary disease. Int J Neurosci. 1982;16(2):99–105.

    Article  PubMed  CAS  Google Scholar 

  24. Incalzi RA et al. Verbal memory impairment in COPD: its mechanisms and clinical relevance. Chest. 1997;112(6):1506–13.

    Article  PubMed  CAS  Google Scholar 

  25. Hjalmarsen A et al. Effect of long-term oxygen therapy on cognitive and neurological dysfunction in chronic obstructive pulmonary disease. Eur Neurol. 1999;42(1):27–35.

    Article  PubMed  CAS  Google Scholar 

  26. Kozora E et al. Improved neurobehavioral functioning in emphysema patients following lung volume reduction surgery compared with medical therapy. Chest. 2005;128(4):2653–63.

    Article  PubMed  Google Scholar 

  27. Klein M et al. Impact of chronic obstructive pulmonary disease (COPD) on attention functions. Respir Med. 2010;104(1):52–60.

    Article  PubMed  CAS  Google Scholar 

  28. Hung WW et al. Cognitive decline among patients with chronic obstructive pulmonary ­disease. Am J Respir Crit Care Med. 2009;180(2):134–7.

    Article  PubMed  Google Scholar 

  29. Herzog AR, Wallace RB. Measures of cognitive functioning in the AHEAD Study. J Gerontol B Psychol Sci Soc Sci. 1997;52:37–48. Spec No.

    Article  PubMed  Google Scholar 

  30. Fix AJ et al. Cognitive functioning and survival among patients with chronic obstructive ­pulmonary disease. Int J Neurosci. 1985;27(1–2):13–7.

    Article  PubMed  CAS  Google Scholar 

  31. Kozora E et al. Cognitive functioning in patients with chronic obstructive pulmonary disease and mild hypoxemia compared with patients with mild Alzheimer disease and normal controls. Neuropsychiatry Neuropsychol Behav Neurol. 1999;12(3):178–83.

    PubMed  CAS  Google Scholar 

  32. Antonelli Incalzi R et al. Cognitive impairment in chronic obstructive pulmonary disease – a neuropsychological and spect study. J Neurol. 2003;250(3):325–32.

    Article  PubMed  Google Scholar 

  33. Incalzi RA et al. Chronic obstructive pulmonary disease. An original model of cognitive decline. Am Rev Respir Dis. 1993;148(2):418–24.

    PubMed  CAS  Google Scholar 

  34. Antonelli-Incalzi R et al. Correlation between cognitive impairment and dependence in hypoxemic COPD. J Clin Exp Neuropsychol. 2008;30(2):141–50.

    Article  PubMed  Google Scholar 

  35. Etnier J, Johnston R, Dagenbach D et al. The relationships among pulmonary function, aerobic fitness, and cognitive functioning in older COPD patients. Chest. 1999;116:953–60.

    Google Scholar 

  36. Incalzi RA, Corsonello A, Trojano L et al. Cognitive training is ineffective in hypoxemic COPD: a six-month randomized controlled trial. Rejuvenation Res. 2008;11:239–50.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paula Meek .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Meek, P. (2012). Cognitive Function. In: Nici, L., ZuWallack, R. (eds) Chronic Obstructive Pulmonary Disease. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-673-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-673-3_8

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-672-6

  • Online ISBN: 978-1-60761-673-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics